Gimmicky isht like this is never a good sign
1/ Some signs to look for that suggest your startup equity won't be worth shit
(note: there are probably exceptions but generally, these will steer you right)
Gimmicky isht like this is never a good sign
That's ok at the early stages but eventually you gotta build some shit for customers
If you're bragging about your investors at Series B, C, the actual biz model is fundraising
This is co revenue / total raised
Esp problematic as companies get more mature
The best companies are machines at turning $ raised into revenue at some point
Bit more here https://t.co/xo0rNZ631n
Some SaaS revenue/raise ratios of cos (anonymized) who've raised in last 3 months.
— Anand Sanwal (@asanwal) November 30, 2018
Collaboration software = 0.25-0.37x
Research & data analytics = 0.28x
Biz Intelligence = 0.12x
Some comparison points
Domo pre-IPO = 0.16x
Tableau (at IPO) = 8.51x
Frothy out there or rational?
In 2020, they said they'd do $25M in revenue to a journalist
In 2021, tell other journo they did $15M in 2020 and are expecting $50M in 2021
Beware of team good at storytelling but who stink at actual delivery
Personal brand building founders trying to be 'gurus' are almost always a total dumpster fire
These folks aren't actually motivated by the problem they're solving. They just see an opportunity for a quick flip
They'll get bored when the momentum dies and then they'll pivot to web3
https://t.co/46NzVF6Gu5
10000%
— Anand Sanwal (@asanwal) January 28, 2022
There are going to be a ton of folks whose options are dead money cuz the 409a is very close to preferred share price AND the preferred share price is just too damn high
If joining a startup, heed this advice https://t.co/tuKcwGEvm8
https://t.co/VF2ySmZb7k
Your startup has more than 5 people
— Anand Sanwal (@asanwal) December 12, 2021
Here's 18 things you can do in 2022 to screw it up
Want your startup to end 2022 weaker than when you started?
Follow these tips
\U0001f9f5 (ya, I know)
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs