BC VACCINE MANUFACTURING DIFFICULTIES
Saved by @khatvaanga

Vaccine supply chain management is a careful balancing act everywhere right now. Here’s a sampling of news to offer context:

US: https://t.co/d4C038NVrK

1/

 UK: https://t.co/LnGxuqJbkv

2/
Shortages in California in late March: https://t.co/ixaLo0oYPm

3/
UK supply disruptions late March: https://t.co/BStPj9rYGV

4/
Germany update late March : https://t.co/rlamkakowz

5/
Japan, which started this week after several delays - https://t.co/Em3wW0PTRm

6/
For context, India has multiple vaccines. It produces it all at home. One is entirely homegrown IP. The other we licensed because we have the demonstrated scale to make it at home.

7/
Multiple developed countries lack their own IP and manufacturing base. They are dependent on the vagaries of Pfizer supply choices made in another country: https://t.co/ZZxYmEgKT0

8/
The scale of Indian vaccine production is under appreciated:

https://t.co/u5n7hiZBSC

Table 4: of $155 billion in saved medical costs btwn 2001-20, SII’s vaccines alone contributed to $140 billion savings

9/
Here’s some additional data from WHO summarizing vaccine and generics suppliers (https://t.co/BafB9byVsp) . Page 5 and 6 are interesting.

10/
The current situation despite the existing manufacturing and development prowess is difficult - scale up production multiple times prior baseline, while simultaneously maintaining quality without any interruption. Distribute without any bottleneck anywhere.

11/
Most do not even have the luxury of having local supply, even if raw material is imported in some cases.

Ordering Pfizer in Sept 2020 hasn’t ensured EU reliable supplies as of April 2021. Pfizer is made in US, Belgium and Germany.

12/
The UK delayed second dose guidance to up to 12 weeks: https://t.co/QdXpj4Rtxq

… and exploring giving different vaccines for 2 doses: https://t.co/xRHiW4eiXK

13/
It’s beneficial to understand the challenges in a clear and unemotional manner.

To educate on the complexities of vaccine IP, let a famed immunologist speak. To understand how complex supply chain works, let someone who has run complex intl supply chain speak.

14/
The Indian population counts amongst it some of the most accomplished individuals in every aspect related to how this process works.

The population values education and deserves to learn the details and nuances of the problem and appreciate the nature of the challenge.

15/
A continuous stream of mind-numbing sensationalism does not serve the needs of the modern Indian state. We have amongst ourselves some of the worlds best medical professionals, technocrats, logistics and operations experts .

16/
People need to be able to clearly learn what they have to say about the various challenges associated with an effort on this scale and complexity. The effort needs to be benchmarked against the problems others are also facing.

17/
The role of the press here is to connect the expert knowledge directly to the public in clear understandable language. It cannot by itself monopolize the conversation. It leads to embarrassing gaffes like someone not knowing that Remdesivir is a chemical.

18/
The press isn’t expect to be domain experts and should pretend to be one. It has a job to connect the experts to the public and to let the public quietly learn and understand the details of the medical, technological and operational challenges itself.

19/19

You May Also Like

Meet Shah
Meet Shah
@ms89_meet
Strong Monopolies:

IRCTC 100% Market share in Rail Network.

IEX >90% market share in power trading.

Zydus wellness >90% market share in sugar free product.

Eicher motors >85% market share in 250cc bikes category.

MCX >85% market share in commodity trading.

Coal India >80% market share in coal production in India.

ITC >75% market share in cigarettes.

Honda Siel >75% in portable power generators.

Hindustan Zinc >75% market share in primary zinc industry.

Asahi India Glass >70% market share in automotive glass.

NRB Bearings >70% market share in needle roller bearings.

Pidilite >65% market share in adhesives.

CAMS >65% market share in RTA within mutual fund industry.

Time Technoplast >65% market share in polymer based industrial packaging.

Concor >65% market share in domestic container cargo transport.

Exide >60% market share in lead batteries.

Naukri >60% market share in the Indian job market space.

Praj >60% market share in ethanol plant installing.

Indiamart Intermesh >55% market share in the online B2B Classified space.

Borosil Renewables >55% market share in Lab glass.

Vst Tillers >50% market share in
Power tillers.

Delta corp >50% in online poker games.

Vinati Organics >50% market share in IBB.
GENERICLEARNINGS , GENERAL TWEER , INTRESTING TOPIC
Caleb Porzio
Caleb Porzio
@calebporzio
🎉🎉 PHP 7.3 is here!

Here are the things I'm excited about.

🚂 Trailing commas in function/method calls!

This will certainly be a required styling choice for me. Same delightful benefits of trailing comma in multi-line PHP arrays, and JavaScript objects.


🧵 Less disgusting heredoc syntax!

Inlining heredoc strings in any way right now is grrrosssss. Now we get sensible capabilities. Everything that was wrong with it is now fixed!

(Ignore the bad syntax highlighting)


☠️ Finally, not-so-silent json_decode error detection!

This really sucked before, now it just sucks a bit less (who wants to pass a 4th param and pass 2 default params first? (helper function anybody?)


📜 Not horrible functions for getting the first and last item (or key) from an array!

Before you either strung a bunch of functions together or messed with internal array pointers. This is a much-needed improvement.
TECH
Advertisement
foone
foone
@Foone
So there's a class of puzzles called "river crossing puzzles" which involve having to cross a river on a boat/bridge containing some set of individuals/items with restrictions on which ones can be on the boat/left on each shore, right?

and the most common subclass of these problems is the one where you have 3 items/animals to cross with.
This is alternatively called the "fox, goose, and bag of beans" or "wolf, goat, and cabbage" puzzle.

the idea is that your boat can only carry one item at a time, but if you leave the wolf/fox unattended with the goat/goose, the wolf/fox will eat the goat/goose.
and similarly, the goose/goat will eat the beans/cabbage if left alone

so you have to set up a set of actions that never leaves either side of the river in one of the lose-states.

the solution to this variant being:
1. take the goat/goose over
2. return empty
3. take the wolf/fox over
4. return with the goat/goose
5. take the cabbage/beans over
6. return empty
7. take the goat/goose over
GAMES
Anu Satheesh \U0001f1ee\U0001f1f3
Anu Satheesh 🇮🇳...
@AnuSatheesh5
Thirumalai Murugan Kovil
#Panpoli
#TamilNaduTemples 🚩

Thirumalai Murugan Temple is located in Tenkasi district of Tamil Nadu. Muruga is worshipped as Thirumalai kumarasamy. Temple is situated near Kerala border and known to be where Shri Murugan gave darshan to Rishi Agasthiar


Devi is worshipped in the temple as Thirumalai Kaali amman

Sthala Puranam says that, there was a priest named Poovanbhattar of Thirumalai Kaali amman. Murugar appeared in a dream of the bhattar and said to find a Vigraham, lying in particular place which is of Thirumalaikumaran


Bhattar conveyed the news to the Pandalam Raja and they went to find out the vigraham. Surprisingly ants showed the way to find the Vigraham. Thus Murugan vigraham was found and Prathista was done here. There is a lake with pure water on the top of the hill


which is said to be created by Agasthiyar. It is believed that kannaki of
Chilapathikaram visited here before going to Kerala. Sapthamathrukkal also worshipped Murugan here. Kanthashashti Thiruvizha is very famous here.

Om Muruga
Muruganukku Harohara
🙏🕉🙏
ALL
Anumah, Abdulraheem Okehi \U0001f468\u200d\U0001f52c\U0001f1f3\U0001f1ec \U0001f1eb\U0001f1f7 \U0001f1f5\U0001f1f9 \U0001f1ea\U0001f1f8
Anumah, Abdulraheem Ok...
@AnumahABD
Department List of UCAS-China PROFESSORs for ANSO, CSC and UCAS (fully or partial) Scholarship Acceptance
1) UCAS School of physical sciences Professor
https://t.co/9X8OheIvRw
2) UCAS School of mathematical sciences Professor

3) UCAS School of nuclear sciences and technology
https://t.co/nQH8JnewcJ
4) UCAS School of astronomy and space sciences
https://t.co/7Ikc6CuKHZ
5) UCAS School of engineering

6) Geotechnical Engineering Teaching and Research Office
https://t.co/jBCJW7UKlQ
7) Multi-scale Mechanics Teaching and Research Section
https://t.co/eqfQnX1LEQ
😎 Microgravity Science Teaching and Research

9) High temperature gas dynamics teaching and research section
https://t.co/tVIdKgTPl3
10) Department of Biomechanics and Medical Engineering
https://t.co/ubW4xhZY2R
11) Ocean Engineering Teaching and Research

12) Department of Dynamics and Advanced Manufacturing
https://t.co/42BKXEugGv
13) Refrigeration and Cryogenic Engineering Teaching and Research Office
https://t.co/pZdUXFTvw3
14) Power Machinery and Engineering Teaching and Research
EDUCATION