So - that was quite a twitter/media day for me, and welcome to my new followers; 3 threads coming up - introducing myself, explaining my background and COIs (this one); technical aspects of the new strain from my vantage; commentary on what is means for the future

(for the people who know me, skip the rest of this thread!)
A brief tweet portrait of me; I am deputy director general of @embl and co-direct (with Rolf Apweiler, not on twitter) one it's six sites, @emblebi which is based just south of Cambridge, UK.
@embl is the European Molecular Biology Laboratory, a European treaty organisation that does science, similar to CERN. EMBL does molecular biology from high end atomic structural biology to development - and in the future, bridging to Ecosystems.
EMBL is Headquartered in beautiful Heidelberg, Germany and has 5 other sites; Hamburg (Germany also), Grenoble (France), EMBL-EBI at Hinxton (UK), Rome (Italy) and Barcelona (Spain).
Like CERN, the EMBL treaty is separate from EU treaties (though we have a very productive relationship and agreement with the EU); Israel and Switzerland were both founding members of EMBL in 1973. As such Brexit does not legally effect EMBL-EBI in the UK >>
<< though it has many impacts on the operational details and general tenor of the staff at EMBL-EBI, both EU nationals @emblebi, British nationals and non-EU nationals (we are very international in our recruitment)
Overall @embl has 5 missions - Excellent Research, world class scientific services, Training (all career levels), dissemination to industry and European science coordination. @emblebi is focused on bioinformatics - data science in biology - and contributes to all of these
In particular @emblebi provides the world with public molecular biology information; most iconic is the human genome sequence and its associated annotation, but this thread goes far deeper; from the 1970s for protein structures, 1980s for DNA sequence.
In the pandemic @emblebi has provided the technical centre piece to https://t.co/N47Vc4mBnz which enabling worldwide sharing of molecular data on COVID19 - DNA, protein, structures, and impact on the human host (expression changes, human genetics, done in a responsible way)
My own personal expertise is both algorithms around DNA and more recently outbred genetics, in both humans and Japanese Medaka fish.
When life is a little slower I will hopefully regale you all on Medaka fish genetics and phenotypes (its... slow science, and all the better for it) but the main thing about this field is two fold
(a) Data science in biology - aka Bioinformatics - gets hooked into all sorts of parts of biology, and one often reuses a fundamental toolkit (processing, models, statistics) in disparate fields - it really is a wonderful "freedom to roam" and means I collaborate broadly
(b) It is very international, both in data sharing worldwide (such a good thing for humanity I can't tell you - this pandemic being one example!) and also human genetics is very much a global village - we are a small group of upright apes that have exploded quickly worldwide
The final thing to add is that I often work with companies - I have a very porous view of how academia and companies should work in terms of expertise, and then sharp discontinuities about which problems are better solved in the public sphere, and which via private money
(so - I don't find it *at all* a problem that I am for open science and also cheerlead/support companies in general and a specific set of companies; rather it is "for this problem, what is the best structure to solve it")
As such I have a list of companies I have consulted for; am consulting for now; and may well consult for. For the "past" it includes, a long time back, Compugen in Israel, more recent past being GSK (the pharma company)
For the present I am a long standing consultant to @nanopore , which makes a new COVID test (LamPORE); as such I have a clear COI on testing which I try to be squeaky clean about announcing (much to people's amusement).
The other current consultancy of note is @DTGenomics which has a variety of clever library techniques, in particular proximity ligation for assemblies, structural variation and chromatin structure. They don't have a COVID line but they might.
For the future... I can't say (obviously) but what I do aim for is transparency with everyone. As @Spikew3 from nanopore says "Better a conflict of interest than a lack of interest" and being transparent is the start to this.

More from Twitter

This is why I'm not a critic of "cancel culture." It's crucial to impose social costs for the breech of key social norms. The lesson of overreaction is that we need to recalibrate judgment to get it right next time, not that we need a lot more bad judgment in the other direction.


Obviously, people will disagree about which norms are important, about how bad it is to violate them, and thus about how severe the social cost ought to be. That's just pluralism, man, and it's good.

It's important to openly talk through these substantive differences, which is why derailing these conversations with hand-waving moral panic about "cancel culture" is obnoxious and illiberal.

Screaming "cancel culture!" when somebody pays a social costs other people have been fighting hard to get others to see as necessary is often just a way to declare, with no argument, that the sanction in question was not only unnecessary but in breach of a more important norm.

It's impossible to uphold social norms without social sanctions, so obviously anti-cancelers are going to want to impose a social cost on people they see as imposing unjustly steep social costs on others.
Today's Twitter threads (a Twitter thread).

Inside: ADT insider threat; Billionaires think VR stops guillotines; Privacy Without Monopoly; and more!

Archived at: https://t.co/nu1HbReiEX

#Pluralistic

1/


This Wednesday, I'm giving a talk called "Technology, Self-Determination, and the Future of the Future" for the Purdue University CERIAS Program:

https://t.co/po5IivZyr4

2/


ADT insider threat: If you build it they will spy.

https://t.co/kJrmtu8L3S

3/


Billionaires think VR stops guillotines: TARP with tasps.

https://t.co/MIKwvsICkr

4/


Privacy Without Monopoly: Podcasting a reading of the latest EFF whitepaper.

https://t.co/R2sl75y4rb

5/

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I think a plausible explanation is that whatever Corbyn says or does, his critics will denounce - no matter how much hypocrisy it necessitates.


Corbyn opposes the exploitation of foreign sweatshop-workers - Labour MPs complain he's like Nigel

He speaks up in defence of migrants - Labour MPs whinge that he's not listening to the public's very real concerns about immigration:

He's wrong to prioritise Labour Party members over the public:

He's wrong to prioritise the public over Labour Party
I hate when I learn something new (to me) & stunning about the Jeff Epstein network (h/t MoodyKnowsNada.)

Where to begin?

So our new Secretary of State Anthony Blinken's stepfather, Samuel Pisar, was "longtime lawyer and confidant of...Robert Maxwell," Ghislaine Maxwell's Dad.


"Pisar was one of the last people to speak to Maxwell, by phone, probably an hour before the chairman of Mirror Group Newspapers fell off his luxury yacht the Lady Ghislaine on 5 November, 1991."
https://t.co/DAEgchNyTP


OK, so that's just a coincidence. Moving on, Anthony Blinken "attended the prestigious Dalton School in New York City"...wait, what? https://t.co/DnE6AvHmJg

Dalton School...Dalton School...rings a

Oh that's right.

The dad of the U.S. Attorney General under both George W. Bush & Donald Trump, William Barr, was headmaster of the Dalton School.

Donald Barr was also quite a


I'm not going to even mention that Blinken's stepdad Sam Pisar's name was in Epstein's "black book."

Lots of names in that book. I mean, for example, Cuomo, Trump, Clinton, Prince Andrew, Bill Cosby, Woody Allen - all in that book, and their reputations are spotless.
1/ Some initial thoughts on personal moats:

Like company moats, your personal moat should be a competitive advantage that is not only durable—it should also compound over time.

Characteristics of a personal moat below:


2/ Like a company moat, you want to build career capital while you sleep.

As Andrew Chen noted:


3/ You don’t want to build a competitive advantage that is fleeting or that will get commoditized

Things that might get commoditized over time (some longer than


4/ Before the arrival of recorded music, what used to be scarce was the actual music itself — required an in-person artist.

After recorded music, the music itself became abundant and what became scarce was curation, distribution, and self space.

5/ Similarly, in careers, what used to be (more) scarce were things like ideas, money, and exclusive relationships.

In the internet economy, what has become scarce are things like specific knowledge, rare & valuable skills, and great reputations.