BC TECH
Saved by @CodyyyGardner

Check out our last preprint- We use single-cell & spatial technologies to map the human uterus and inform organoids experiments

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

 We generate single-cell and spatial reference maps of the human uterus and dissect the signalling pathways that determine cell fate of the epithelial lineages in the lumenal and glandular microenvironments.
To study cell-signalling we use Cell2location (@vitaliikl) and develop CellPhoneDBv3 that considers cellular coordinates for the inference of cell-cell communication
We mapped 3D endometrial organoid cultures and benchmark the model to our uterine atlas. To do so, we develop a novel computational pipeline to align in vitro and in vivo datasets.
Our comparison highlights common pathways regulating the differentiation of secretory and ciliated lineage in vivo and in vitro.
Informed by the in vivo dataset, we show in vitro that downregulation of WNT or NOTCH pathways increases the differentiation efficiency along the secretory and ciliated lineages, respectively
We are excited about how our mechanistic insights of the healthy endometrium may help us understand neglected uterine pathologies, such as endometriosis or endometrial cancer
Amazing collaborative work with Turco lab @CamPathology @teichlab @bayraktar_lab led by amazing scientists @LuzGarAl @krobertssci @NikolKons & Louis-F Hanfield
A big thank you @MoffettAm485 for all fruitful discussions & help. Such an amazing journey!
Big thanks also @luiza_moore @KSaebParsy & many others for your guidance, discussions and sample acquisition.

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Cookie Cyboid
Cookie Cyboid
@CookieCyboid
“Why are Tumblr and Facebook cracking down on sex so much? And why is Facebook in so over zealous about it? It’s all Apples fault!” Etc etc

I can explain all. It is largely the fault of a set of US laws called SESTA and FOSTA.
TECH
Daniel Johnson
Daniel Johnson
@DJohnson_CPA
Here’s a SPAC thread covering some basics for new followers. I will pin this to my profile if you want to share to anyone interested in SPACs.

SPAC timelines consist of these stages:
IPO – SPAC raises cash and begins trading as a unit. The cash is placed in Trust.
Searching phase – After IPO, the SPAC management team looks for a company to merge with. This is typically 24 months but can be shorter depending on the SPAC

LOI/Rumor – A letter of intent is announced publicly or Bloomberg/Reuters etc. breaks news of a rumor that a SPAC is close to a deal with a target.

The LOI/rumor stage does not always happen, most go straight to a definitive agreement. Rumors should only be considered to have value if from a trusted news source, internet rumblings are pure speculation. During this stage, a deal can still fall apart and not be signed.

Definitive agreement (DA) – deal officially inked. The SPAC begins filing paperwork with the SEC to have the merger approved to take the target company public. This process typically takes 4+ months after the DA is announced.
TECH
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Alex Stamos
Alex Stamos
@alexstamos
The entire discussion around Facebook’s disclosures of what happened in 2016 is very frustrating. No exec stopped any investigations, but there were a lot of heated discussions about what to publish and when.


In the spring and summer of 2016, as reported by the Times, activity we traced to GRU was reported to the FBI. This was the standard model of interaction companies used for nation-state attacks against likely US targeted.

In the Spring of 2017, after a deep dive into the Fake News phenomena, the security team wanted to publish an update that covered what we had learned. At this point, we didn’t have any advertising content or the big IRA cluster, but we did know about the GRU model.

This report when through dozens of edits as different equities were represented. I did not have any meetings with Sheryl on the paper, but I can’t speak to whether she was in the loop with my higher-ups.

In the end, the difficult question of attribution was settled by us pointing to the DNI report instead of saying Russia or GRU directly. In my pre-briefs with members of Congress, I made it clear that we believed this action was GRU.
TECH
Tobie Langel
Tobie Langel
@tobie
Elastic didn't really relicense ElasticSearch. It forked it.

🧵 A thread.

1/18

There's a lot of talk in the open source community about the cost of forking.

2/18

- "Forking is best avoided."

- "Forking is a last resort option."

- "Forking is like a nuclear weapons. It's a defensive threat."

3/18

Forking is seen as impractical and extremely expensive.

And that's a Really Good Thing(tm).

It's a forcing function for figuring out solutions that are broadly acceptable across the community.

4/18

The thing is, the cost of forking is mostly a function of three things:

1⃣ the size of the community that you can bring along with you,
2⃣ whether you need to rename your fork (who owns the trademark), and
3⃣ how much infrastructure you need to rebuild.

5/18
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Paul Matzko
Paul Matzko
@PMatzko
The New York Times article about SlateStarCodex is finally out and it is...bad. There's a lot I could parse, but let me just walk you through one paragraph that is so misleading as to be

Take the first sentence of this paragraph. Now, technically the clause--"who proposed a link between race and IQ"--could simply modify "Murray" and have nothing to do w/ SSC.


But 99% of readers are going to assume that the clause actually defines SSC's alignment with Murray. In other words, the author is strongly implying that SSC shares Murray's racist beliefs.

And that would be big(!)...if it were at all true. It is not. Indeed, if you go to the hyperlink, you'll find that SSC's purported "alignment" has nothing to do with Murray's "Bell Curve."

What SSC & Murray agree about is that poverty is partly hereditable and thus very sticky, so much so that the proposition job retraining programs will meaningfully address mass economic disruption is a pie-in-the-sky fantasy.
TECH

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1. I was walking in the woods yesterday and I had an epiphany. It wasn’t one I wanted to have. I was thinking about today’s class, where we are reading Kimmerer’s ‘Gathering Moss’. I’ve taught Braiding Sweetgrass in multiple classes every year since 2016. It’s eminently teachable

2. Both books are beautifully written. Students uniformly enjoy them as assigned reading. They do a great job communicating to non-Indigenous folks the contours of basic Indigenous relationships to more-than-human beings. They’re wildly popular with white readers.

3. I’ve found Braiding Sweetgrass to be a great entry point for non-Indigenous folks to Indigenous scholarship. But this is where yesterday’s epiphany comes in. Neither Braiding Sweetgrass or Gathering Moss tends to the deep deep lineages of Indigenous scholarship in Canada or US

4. As the popularity of ‘Braiding Sweetgrass’ has soared, I’ve seen more and more white folks wax on about ‘braiding knowledge’. But they often don’t know any of the lineages of these concepts beyond what is presented in this one book. They confidently run with this.

5. Kimmerer does a commendable job of weaving in her own experiences, her family stories+nods to some very important knowledge keepers who deserve to be celebrated for their work. But Braiding Sweetgrass does not tend to the citational politics Sara Ahmed & others teach us about
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H was always unseen in S2NL :)

Those who exited at 1500 needed money. They can always come back near 969. Those who exited at 230 also needed money. They can come back near 95.

Those who sold L @ 660 can always come back at 360. Those who sold S last week can be back @ 301
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Naval
Naval
@naval
How to Get Rich (without getting lucky):

Seek wealth, not money or status. Wealth is having assets that earn while you sleep. Money is how we transfer time and wealth. Status is your place in the social hierarchy.

Understand that ethical wealth creation is possible. If you secretly despise wealth, it will elude you.

Ignore people playing status games. They gain status by attacking people playing wealth creation games.

You’re not going to get rich renting out your time. You must own equity - a piece of a business - to gain your financial freedom.
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Margatha Natarajar murthi - Uthirakosamangai temple near Ramanathapuram,TN
#ArudraDarisanam
Unique Natarajar made of emerlad is abt 6 feet tall.
It is always covered with sandal paste.Only on Thriuvadhirai Star in month Margazhi-Nataraja can be worshipped without sandal paste.


After removing the sandal paste,day long rituals & various abhishekam will be https://t.co/e1Ye8DrNWb day Maragatha Nataraja sannandhi will be closed after anointing the murthi with fresh sandal paste.Maragatha Natarajar is covered with sandal paste throughout the year


as Emerald has scientific property of its molecules getting disturbed when exposed to light/water/sound.This is an ancient Shiva temple considered to be 3000 years old -believed to be where Bhagwan Shiva gave Veda gyaana to Parvati Devi.This temple has some stunning sculptures.
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ashkan soltani
ashkan soltani
@ashk4n
BREAKING: @CommonsCMS @DamianCollins just released previously sealed #Six4Three @Facebook documents:

Some random interesting tidbits:

1) Zuck approves shutting down platform API access for Twitter's when Vine is released #competition


2) Facebook engineered ways to access user's call history w/o alerting users:

Team considered access to call history considered 'high PR risk' but 'growth team will charge ahead'. @Facebook created upgrade path to access data w/o subjecting users to Android permissions dialogue.


3) The above also confirms @kashhill and other's suspicion that call history was used to improve PYMK (People You May Know) suggestions and newsfeed rankings.

4) Docs also shed more light into @dseetharaman's story on @Facebook monitoring users' @Onavo VPN activity to determine what competitors to mimic or acquire in 2013.

https://t.co/PwiRIL3v9x
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