What happens when a skill you have becomes obsolete? No, this isn't a R vs. Stata thread---it's a thread about a working paper w/ @sonnytambe!
https://t.co/w6nLf1tnST
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On Wednesday, The New York Times published a blockbuster report on the failures of Facebook’s management team during the past three years. It's.... not flattering, to say the least. Here are six follow-up questions that merit more investigation. 1/
1) During the past year, most of the anger at Facebook has been directed at Mark Zuckerberg. The question now is whether Sheryl Sandberg, the executive charged with solving Facebook’s hardest problems, has caused a few too many of her own. 2/ https://t.co/DTsc3g0hQf
2) One of the juiciest sentences in @nytimes’ piece involves a research group called Definers Public Affairs, which Facebook hired to look into the funding of the company’s opposition. What other tech company was paying Definers to smear Apple? 3/ https://t.co/DTsc3g0hQf
3) The leadership of the Democratic Party has, generally, supported Facebook over the years. But as public opinion turns against the company, prominent Democrats have started to turn, too. What will that relationship look like now? 4/
4) According to the @nytimes, Facebook worked to paint its critics as anti-Semitic, while simultaneously working to spread the idea that George Soros was supporting its critics—a classic tactic of anti-Semitic conspiracy theorists. What exactly were they trying to do there? 5/
1) During the past year, most of the anger at Facebook has been directed at Mark Zuckerberg. The question now is whether Sheryl Sandberg, the executive charged with solving Facebook’s hardest problems, has caused a few too many of her own. 2/ https://t.co/DTsc3g0hQf
2) One of the juiciest sentences in @nytimes’ piece involves a research group called Definers Public Affairs, which Facebook hired to look into the funding of the company’s opposition. What other tech company was paying Definers to smear Apple? 3/ https://t.co/DTsc3g0hQf
3) The leadership of the Democratic Party has, generally, supported Facebook over the years. But as public opinion turns against the company, prominent Democrats have started to turn, too. What will that relationship look like now? 4/
4) According to the @nytimes, Facebook worked to paint its critics as anti-Semitic, while simultaneously working to spread the idea that George Soros was supporting its critics—a classic tactic of anti-Semitic conspiracy theorists. What exactly were they trying to do there? 5/
There has been a lot of discussion about negative emissions technologies (NETs) lately. While we need to be skeptical of assumed planetary-scale engineering and wary of moral hazard, we also need much greater RD&D funding to keep our options open. A quick thread: 1/10
Energy system models love NETs, particularly for very rapid mitigation scenarios like 1.5C (where the alternative is zero global emissions by 2040)! More problematically, they also like tons of NETs in 2C scenarios where NETs are less essential. https://t.co/M3ACyD4cv7 2/10
In model world the math is simple: very rapid mitigation is expensive today, particularly once you get outside the power sector, and technological advancement may make later NETs cheaper than near-term mitigation after a point. 3/10
This is, of course, problematic if the aim is to ensure that particular targets (such as well-below 2C) are met; betting that a "backstop" technology that does not exist today at any meaningful scale will save the day is a hell of a moral hazard. 4/10
Many models go completely overboard with CCS, seeing a future resurgence of coal and a large part of global primary energy occurring with carbon capture. For example, here is what the MESSAGE SSP2-1.9 scenario shows: 5/10
Energy system models love NETs, particularly for very rapid mitigation scenarios like 1.5C (where the alternative is zero global emissions by 2040)! More problematically, they also like tons of NETs in 2C scenarios where NETs are less essential. https://t.co/M3ACyD4cv7 2/10
There is a lot of confusion about carbon budgets and how quickly emissions need to fall to zero to meet various warming targets. To cut through some of this morass, we can use some very simple emission pathways to explore what various targets would entail. 1/11 pic.twitter.com/Kriedtf0Ec
— Zeke Hausfather (@hausfath) September 24, 2020
In model world the math is simple: very rapid mitigation is expensive today, particularly once you get outside the power sector, and technological advancement may make later NETs cheaper than near-term mitigation after a point. 3/10
This is, of course, problematic if the aim is to ensure that particular targets (such as well-below 2C) are met; betting that a "backstop" technology that does not exist today at any meaningful scale will save the day is a hell of a moral hazard. 4/10
Many models go completely overboard with CCS, seeing a future resurgence of coal and a large part of global primary energy occurring with carbon capture. For example, here is what the MESSAGE SSP2-1.9 scenario shows: 5/10
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs