@Iplaywithgerms This paper gives documentation on software (with causal reasoning, assumptions reviewed in appendix) for a parametric approach to estimating either "total effects" or "controlled direct effects" with competing events and time-varying

@JuliaLMarcus @Iplaywithgerms Total effects capture paths by which treatment affects competing event (e.g. protective total effect of lifesaving treatment on dementia may be wholly/partially due to effect on survival). Controlled direct effects do not capture these paths
@JuliaLMarcus @Iplaywithgerms More detailed reasoning on the difference and tradeoffs between total and controlled direct effects and causal reasoning in the point treatment context provided here along with description of some estimators and code.
https://t.co/uRQcU1NqJd
@JuliaLMarcus @Iplaywithgerms If you are familiar with more robust approaches like IPW or even better TMLE for time-varying treatment, these are trivially adapted to go after the controlled direct effect by simply treating competing events like loss to follow-up (censoring). e.g. see
https://t.co/kew3HltAev
@JuliaLMarcus @Iplaywithgerms Examples of IPW estimation of the total effect of a time-varying treatment described in Appendix D of this paper:
https://t.co/RNhcgTBMkb
And here
https://t.co/rMWmwFBWwV
Others in reference lists of above papers.
@JuliaLMarcus @Iplaywithgerms As discussed here
https://t.co/uRQcU1NqJd
even when treatment is time-fixed, hazard ratios (whether cause-specific or subdistribution) do not quantify causal effects (even when counterfactual contrasts) except in special circumstances that will not hold in most studies
@JuliaLMarcus @Iplaywithgerms These circumstances can fail even when the study is a perfectly executed trial (no loss to follow-up, perfect adherence to the treatment assignment) and even when the treatment does not affect the competing event.
@JuliaLMarcus @Iplaywithgerms More recent work on the separable effects provides notions of mechanism in this setting that, unlike controlled direct effects (effects under eliminating competing events), have real-world, clinical relevance. This does not accommodate t-v treatments (yet, in the works).
@JuliaLMarcus @Iplaywithgerms Here are some papers on the separable effects for point treatments (Epidemiology commentary forthcoming focused on fertility trials that is less technical):
https://t.co/35OJDe8dD6
https://t.co/O08FNqPWWb
https://t.co/wKCrItvNhT

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🚨 🦮 Seven ways to test for accessibility using only what is already in browser developer tools of Chromium browsers https://t.co/C7kdbigHGE

@MSEdgeDev @EdgeDevTools @ChromiumDev
#tools #accessibility #browsers
Also, a thread: 👇🏼


Issues pane, powered by @webhintio, listing accessibility issues with explanations why these are problems, links to more info and direct links to the tools where to fix the problem.
https://t.co/4K5RynHhbg


The inspect element overlay showing accessibility relevant information of the element, including contrast information, ARIA name, role and if it can be focused via keyboard.


Colour picker with contrast information offering colours that are AA/AAA compliant. You can also see compliant colours indicated by a line on the colour patch.
Note: the current algorithm fails to take font weight into consideration, that's why there will be a new one.


Vision deficit ("colour blindness") emulation. You can see what your product looks like for different visitors.
https://t.co/bxj1vySCAb
forgive my indulgence but 2020's been a big year for @shmuplations, so here's a look back at everything that went up over the last twelve months—there's a lot of stuff I'm sure you all read & other things you'd be forgiven for missing, so let's recap (thread)

the year kicked off with shmuplations' first big video project: a subtitled translation of a 2016 NHK documentary on the 30th anniversary of Dragon Quest which features interviews with Yuji Horii, Koichi Nakamura, Akira Toriyama, and Koichi Sugiyama
https://t.co/JCWA15RTlx


following DQ30 was one of the most popular articles of the year: an assortment of interviews with composers Yuzo Koshiro and Motohiro Kawashima concerning the music of Streets of Rage 1, 2 & 3 https://t.co/QUtyC9W12Z their comments on SoR3 in particular were full of gems


Game Designers: The Next Generation profiled six potential successors to the likes of Shigeru Miyamoto & Hironobu Sakaguchi, some of who you may recognise: Kazuma Kaneko, Takeshi Miyaji (1966-2011), Noboru Harada, Kan Naitou, Takashi Tokita & Ryoji Amano https://t.co/lWZU3PLvwX


from the 2010 Akumajou Dracula Best Music Collections Box, a subbed video feature on long-time Castlevania composer Michiru Yamane https://t.co/NMJe4ROozR sadly, Chiruru has since passed; Yamane wrote these albums in his honor

https://t.co/orlgPTDsKK

https://t.co/QnQl8KI9IX
Developer productivity, y'all. It is a three TRILLION dollar opportunity, per the stripe report.

Eng managers and directors, we have got to stop asking for "more headcount" and start treating this like the systems problem that it is. https://t.co/XJ0CkFdgiO


If you are getting barely more than 50% productivity out of your very expensive engineers, I can pretty much guarantee you cannot hire your way out of this resourcing issue. 😐

(the stripe report is here:

Say you've got a strategic initiative that 3 engineers to build and support it. Well, they're going to be swimming in the same muddy pipeline as everyone else at ~50%, so you're actually gotta source, hire and train 6, er make that 7 (gonna need another manager too now)...

...which actually understates the problem, because each person you add also adds friction and overhead to the system. Communication, coordination all get harder and processes get more complex and elaborate, etc.

So we could hire 7 people, or we could patch up our sociotechnical system to lose say only 25% productivity to tech debt, instead of 42%? 🤔

By my calculations, that would reclaim 3 engineers worth of capacity given a team of just 17-18 people.

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