🧵 After much deliberation concerning the events of last week concerning homophobia, biphobia, and transphobia in our Catholic schools, Toronto—St. Paul’s New Democrats have decided to act.

COVID Masks: Mechanistic View: Part 2: Fine Aerosol Emissions:

Masks may increase fine aerosol emissions from: 1) nebulization of large droplets into fine aerosols, or 2) friability of certain mask materials creating "aerosolized fomites."

Please share:

Here are the studies:

The question is whether facemasks are actually a source for viral aerosols by:

1) Masks get saturated by large "respiratory droplets" containing viral molecules. Air turbulence against trapped droplets may create aerosols that eventually diffuse around edges. Continued...

Trapped droplets potentially get pushed through the filter media of the mask, getting nebulized into aerosols.

Particles don't always stay in the mask:

Study: Ha'eri 1980

Title: The efficacy of standard surgical face masks: an investigation using "tracer particles"

Albumin tracer particles put inside a surgical mask were dispersed into the room by breathing.

Viral molecules can get airborne from air turbulence.

Study: Liu 2020
Title: Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.
SARS-2-COV sub-micrometer aerosols not tightly bound to surfaces, get airborne when PPE is taken off.

I have been working on pandemic outbreaks for 15 years.

There is a misunderstanding of the difference between the response in much of the West, versus successful countries (including New Zealand and Australia).

Summarizing:

1.Reactive versus proactive and goal oriented.

1/-

2.Mitigation (slowing transmission) versus elimination (stopping transmission)

3.Gradually responding to increasing levels of infection by imposing greater restrictions which enables the infection rate to grow (red zone strategy), …

2/

versus starting with high restrictions to arrest transmission and relaxing restrictions only when the number of new cases is so low that contact tracing or localized short term action can stop community transmission (green zone strategy, including localized "fire fighting").

3/

4.Trying to keep economic activity and travel as open as possible but perpetuating the economic harm and imposing yoyo restrictions, versus making an initial sacrifice of economic activity and travel in order to benefit from the rapid restoration of normal economic activity.

4/

5.Focusing attention on few individuals resistant to social action because of shortsightedness or selfishness, versus recognizing the vast majority do the right thing if given clear guidance and support, which is what matters for success, as elimination is a robust strategy.

5/

Recently heard the podcast by @sikhyaent on Saravana Bhavan founder P Rajagopal, who stalked the young daughter of an employee & had her husband killed. Observations: the podcast's title ('Dosa King') glorifies PR, the script trivialises his crime, calling it a mere "scandal"

It refers to the whole stalking and murder episode as something that led to Rajagopal's "fall" - i.e a story of crime against a woman is turned into a story about the impact of the said crime on its perpetrator, not its victim.

It refers to the stalking victim as a fit antagonist for the protagonist Rajagopal, as Rajagopal's nemesis. But the point is, she set out to be neither. She didn't make him part of her life story. He forcibly, violently disrupted her life.

The podcast ends by telling us how Rajagopal's employees and friends and many others abuse the woman he stalked, for pursuing the case of her husband's murder and bringing Rajagopal to justice. It also tells us that some admire her. And it "asks us to decide" where we stand

I find it disturbing that a story of a powerful man feeling entitled to ruin a woman's life & trying to get away with murder, is turned into a story of HIS "rise, popularity, and fall".

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10