Precisely my philosophy. By interacting with people with different opinions can we learn things that we need to improve or maintain. & it helps shatter this horrible manichean perspective that one side is good & the other is evil, which people in politics tend to use too much.

My little Jacob Wohl story: August 2016, we're sitting around the trading turrets at my office on a bored to tears slow day. Our receptionist said someone was here for his 2pm appointment. None of us had an appointment on schedule. Who is it? we ask? Some guy named Jacob Wohl 1/

Jacob Wohl, for those out of loop, gained quite a bit of notoriety for becoming the youngest guy to ever get himself barred for life from the financial industry. Now he's waiting in our lobby to pitch something. We're a large merchant bank. 2/

Send him in, we said. In walks young Jacob asking to be seeded with $25mm to start a new hedge fund in exchange for an ownership stake in it. Oh, & he needs an office. And a Bloomberg station. And needs to borrow staff until he can hire some guys. And he needs a leased car... 3/

And he needs an answer today. Right now. Because there's a competing offer from Izzy Englander's firm Millenium (we know those guys well). We fight the urge to literally start laughing, but do ask him...hey, you the same guy who got banned by regulators? He didn't even flinch 4/

He went on about that being untrue & handed over a letter he said was from his lawyer who had confirmed he was not barred, had been vindicated but it 'just wasn't in the system yet at the SEC, CFTC'...whatever that means. 5/

Offered a guy a ride from Yaba to Obalende this morning. Just as we're approaching Alagomeji, uncle asked me if he can drive. Said he's not comfortable being driven by a woman. I parked and told him to come and take the wheel. Once he got down, I just zoomed off. Arrant nonsense

Funny thing is the guy is quite young. He can't be more than 25. How can someone that young have this sort of mentality?

I actually did not think that the guy could have wanted to get away with my car at the time. Now that I think of it though, that's a big possibility. We need to be careful out there. These thieves now have different ways of operating

It's funny how so many people who claim to worship "democracy" also dismiss nationalism as selfish xenophobia. Democracy is absolutely meaningless without strong national sovereignty. Under globalism, citizens of any given state have little influence over how they are governed.

Nationalism isn't just mindless tribalism. People are correct to insist their government has a responsibility TO THEM that vastly outweighs any imagined responsibility to foreign governments they have absolutely no influence over, or foreign populations.

We've seen that point taken to absurd extremes by the Left during the Trump administration, with whack-job judges ruling that foreigners have rights that EXCEED those of American citizens, including absolute rights to enter the U.S. and influence its government.

And we're frequently told that some international elite "consensus" completely overrides our ability to make individual decisions - or even to petition our own government, or vote for representatives who disagree with whatever "the world" has supposedly decided.

All of that is the absolute negation of "democracy" in any form, including the dangerous mob rule and majoritarianism that the Left selectively advocates. (Notice they always have a list of things nobody gets to vote on anymore, no matter how strong the majority vote would be.)

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10