THREAD: We have a historic, even generational opportunity ahead of us just 11 days from now. Let me outline it for you. I'm gonna try and make this non-partisan. I hope you don't judge me irretrievably naïve.

I have just received information about a family that has locked up their child at home in isolation because she complained of some aches in her body. They suspected the child as having C19. She was tested and after a couple of days, the test came out negative. 1/n

The girl has already been in isolation for 4 days. Now they are waiting to do another PCR test today to check again because they fear that the first test was done too early and it didn't detect covid. So this little girl will remain in isolation for at least another 24 hrs. 2/n

This is idiocy. Insanity. Ignorance. Cruelty. Simply a crime against children.
The stupid fear and the stupid policies are driving parents to abuse their children. 3/n

Children are not the main source of C19 transmission.

"transmission of SARS-CoV-2 from children under 14 years of age was minimal in primary schools"

I have been working on pandemic outbreaks for 15 years.

There is a misunderstanding of the difference between the response in much of the West, versus successful countries (including New Zealand and Australia).

Summarizing:

1.Reactive versus proactive and goal oriented.

1/-

2.Mitigation (slowing transmission) versus elimination (stopping transmission)

3.Gradually responding to increasing levels of infection by imposing greater restrictions which enables the infection rate to grow (red zone strategy), …

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versus starting with high restrictions to arrest transmission and relaxing restrictions only when the number of new cases is so low that contact tracing or localized short term action can stop community transmission (green zone strategy, including localized "fire fighting").

3/

4.Trying to keep economic activity and travel as open as possible but perpetuating the economic harm and imposing yoyo restrictions, versus making an initial sacrifice of economic activity and travel in order to benefit from the rapid restoration of normal economic activity.

4/

5.Focusing attention on few individuals resistant to social action because of shortsightedness or selfishness, versus recognizing the vast majority do the right thing if given clear guidance and support, which is what matters for success, as elimination is a robust strategy.

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1 of 16: WE ARE ALL JEWS HERE: THE STORY OF RODDIE EDMONDS

One of the most moving and relevant stories of the Battle of the Bulge, or any American Soldier in any war, is that of Master Sergeant Roddie Edmonds, a Knoxville, Tennessee native, who served with the 106th Infantry.

2 of 16:

Roddie was captured early on in the Battle of the Bulge, on December 19th, when Panzer forces plowed through his unit.

He, along with almost his entire regiment, was forced to surrender.

3 of 16:

The men were transported to the Stalag IX-A POW camp in Ziegenhain, Germany.

Roddie was the senior enlisted American Soldier at the site. As such, he was the conduit between all American Soldiers and their German captors.

4 of 16:

In late January, the camp’s commandant, Major Siegmann [pictured here], ordered Roddie, a Christian, to identify all Jewish Soldiers and order them to stand in formation by themselves the next day.

[Jewish Soldiers were a minority within American units]

5 of 16:

Throughout WWII, captured Jewish Soldiers were often tortured and then killed by their German captors.

In fact, Jewish Soldiers had been told to bury their dog tags before capture. The dog tag identified Jews with the letter “H” for Hebrew.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

Thread

"Main jab mar jaun to meri alag se pehchan likh dena,mere lahu se meri peshani pr Hindustan likh dena(After I die,write my identity differently,with blood,write India on my forehead)”- msg on wall in Brijpuri. It's faded.

A year on,we revisit where #DelhiRiots broke out.

Feb 2020 Vs Feb 2021
While the hustle and bustle of the area has returned in severely hit Shiv Vihar, some cracks in the walls, a black smoke patch on the door, a few burnt utensils and a pile of photographs remind the victims of the days and nights they lived in “terror”.

Khushnaz’s daughter Alfiza was six days old on February 25 when the riots broke out near her house. She recalled pressing her palm against the infant’s mouth to prevent her voice from being heard as she cried.

Shawra Begum’s single-storey residence near Medina Masjid has still not been repaired. Looking at the broken and burnt taps of her washroom, Shawra said, “That time reminds me of death.”

Sitting inside his house near Auliya Masjid, Nizamuddin had tears in his eyes thinking about the time. Over 5,000 men were walking and running amok on the streets destroying everything and everyone, he said.