It was some days to Christmas and as a TEAM, they had just finished an intervention for a brother. He was still mulling over certain revelations from the prayers when his wife got a call.

It was from a colleague who was in distress and was crying over the phone in confusion.

Unless we pass laws which support people to enable them to self-isolate properly, any improvements to test & trace will have marginal impact and cases will simply spiral out of control once again as we ease lockdown in December.

A short thread on what we can do and why 👇
1/

Improving the currently poor rates of self-isolation is actually the key point, which many scientists, politicians, & commentators do still seem to be missing.

This requires good public health communication, proper support for those who need to self-isolate, & trust.
2/

Massive testing and tracing will only significantly reduce
transmission if positive cases isolate effectively. Yet
currently fewer than 20% of those who should isolate are fully adherent.

I don't think I need to explain why it's so critical to improve these rates.

3/

Survey data shows intention to adhere to test/trace/isolate behaviours is higher than self-reported adherence: whilst 76% of people intend to share contacts, only 50% of people correctly recognise symptoms &
just 12% get a test, 18% isolate, & 11% of contacts isolate properly.
4

Self-reported ability to self-isolate
is three times lower in those who earn less than £20,000 per year or have less than £100 saved.

5/

I've been wanting to write this thread for a while. It has been inspired by hearing a common thought: why can't people just "listen"? If people just followed the rules, we wouldn't be in this mess. I think this is oversimplification of the problem with COVID: 1/

It is true, there are people who haven't been following guidelines (by definition that happened a LOT at Christmas/NYE in my region), but even before, we know transmission in private gatherings happens. 2/

These private gatherings are pictured to be big raucous parties, but in reality, even before lockdown, this is just people having dinner, watching TV, doing things we did before on a daily basis. These little ripples when added across the country make a big wave.. 3/

...and little can be done about this apart from positive messaging. You can't very well have police patrolling neighbourhoods across the country. 4/

Next thing is we keep hearing over and over and over, stay home. There are diminishing returns with this advice, but also, most people who can stay home ARE. So what's the issue? There are a HUGE # of people who can't stay home because they work in essential jobs 5/

I think the UK trans debate has teased out the sticking points for feminists, and it might be useful to lay them out given that the battle in the US, with a very different legislative environment, is just starting.

The GRA of 2004 gave trans people the ability to change legal sex via a GRC, but only if they had a psychiatric diagnosis of dysphoria and only after having lived in role for 2 years. The spousal veto gave spouses a chance to annul or obtain a favourable divorce.

While this ultimately created the loophole in women's rights that we've been fighting against in the last few years, it catered for a tiny number of dysphoric transsexuals and so did not have an enormous impact.

Discussions with trans friends and allies make it clear that, although surgery wasn't a requirement for a GRC, the diagnostic procedures were expected to trap and exclude males who did not want surgery, thereby preventing fetishists and opportunists from exploiting a GRC.

The Equality Act of 2010 defined the various protected characteristics, including both sex and 'gender reassignment', and provided for sex-based exemptions, under the auspices of which it is legal to exclude trans people from some single-sex spaces and services.

Since a lot of my fellow Texans are going to apply for aid through @FEMA let’s talk about the agency and some of the barriers disaster survivors encounter and persisting program flaws.

First things first, @FEMA is part of the Department of Homeland Security. Here’s a blog I wrote about its history and shortcomings in how the agency is funded:

Many people will be applying for Individual Assistance (IA), but past disasters have shown us that help isn’t evenly distributed and frequently struggles to reach those in deepest need. This unpacks some of the class bias in accepted/rejected apps:

Of course, there are racial dimensions to this as well:

Documentation is seen as helping reduce fraud, but after a disaster many docs are destroyed. People who are denied assistance and appeal are often told to make small changes to the documents they provide or provide updated documentation b/c of how long the aid process takes.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10