BC SCIENCE
Saved by @CodyyyGardner

https://t.co/0BbPc11eTD
The Top 10 Psilocybin Research Papers of 2020
- FS Barrett, MK Doss, ND Sepeda, et al. – Emotions and brain function are altered up to one month after a single high dose of psilocybin. @FredBarrettPhD 1/10

 SB Goldberg, BT Pace, CR Nicholas, et al. – The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis. “meta-analysis of studies using psilocybin along with behavioral interventions to treat elevated symptoms of anxiety and depression.” 2/10
GI Agin-Liebes, T Malone, MM Yalch, et al. – Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer. “follow-up approx 3.2 and 4.5 years later, w/ 15 of the 16 participants still alive” 3/10
F Blei, S Dörner, J Fricke, et al. – Simultaneous production of psilocybin and a cocktail of β‐carboline monoamine oxidase inhibitors in “magic” mushrooms “paper was chosen for Psychedelic Science Review’s 2020 Editor’s Choice Award for best study on psychedelics and nature” 4/10
J Sloshower, J Guss, R Krause, et al. – Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame “lays out how to combine therapy using antidepressant medication (like psilocybin) w/evidence-based psychotherapy” 5/10
LJMertens, MBWall, LRoseman, et al Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression
“↗️amygdala activation in participants day after psilocybin tx” 6/10
NL Mason, KPC Kuypers, F Müller, et al. – Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin. Good One! 7/10
MK Madsen, PMD Fisher, DS Stenbæk, et al. Single psilocybin dose is assoc. w/ long-term ↗️mindfulness, preceded by proportional change in neocortical 5-HT2A receptor binding
1st molecular neuroimaging study examining underlying mechanisms behind long term efx of psilocybin 8/10
KH Preller, P Duerler, JB Burt, et al. – Psilocybin induces time-dependent changes in global functional connectivity “deepen our understanding of the mechanism of action of psychedelic compounds” 9/10
N Milne, P Thomsen, N Malgaard Knudsen, et al. – Metabolic engineering of Saccharomyces cerevisiae for the production of psilocybin and related tryptamine derivatives 10/10 .... there are 4 more studies cited in the blog post.

More from Science

Thomas A. Fine \U0001f1fa\U0001f1f8
Thomas A. Fine 🇺🇸...
@thomasafine
Let's talk about Avi Loeb and his theory about alien

First, I should disclose that I work at the fame research facility as Dr. Loeb, though I work in a different department and to my recollection we've never met.

He's a scientist; I'm in computer support.

With that out of the way...
The interview above is worth a read, and a lot of serious thought, because there's an idea there that's really critical to science, and it isn't whether or not aliens have visited (exactly).

It's about how fashion and culture and taboo have an unfortunately strong effect on science.

In particular he compares his theory on alien visitation with the multiverse theory.

Which of these is more deserving of ridicule?

Science is fundamentally a structure for forming hypotheses and then (critically) testing these hypotheses to see if they should be kept, rejected, or modified.
SCIENCE
Mark Tomasovic
Mark Tomasovic
@MarkTomasovic
What is carbon capture? And how does it work?

While carbon capture is regularly discussed in the media, no one really ever explains what it is.

Below is a quick thread discussing the technology behind traditional carbon capture 👇

Carbon capture is broadly the "capture" of CO2 emissions from a power plant or other type of industrial facility.

Technology is connected to the "tailpipes" of these facilities and is used to remove CO2 from the plant exhaust.

Once the CO2 is removed from the plant exhaust, it is typically pressurized and sent under ground for permanent storage.

This step is called "sequestration" and is why experts often talks about "carbon capture and sequestration" or "CCS".

So how do you "capture" the CO2 molecules from exhaust?

Currently, one of the most economic forms of carbon capture is called "amine-based" capture.

An "amine" is a special liquid chemical which selectively grabs on to CO2 molecules.

To get the amine to grab on to the CO2, the amine is put into the top of a large column, while the exhaust is put into the bottom of the column.

The exhaust bubbles up through the column, and the amine drips down.

The liquid amine and gas exhaust mix in the column.
SCIENCE
Advertisement
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz


2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.

3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.


4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
SCIENCE
Lea Kissner
Lea Kissner
@LeaKissner
Next up at #enigma2021, Sanghyun Hong will be speaking about "A SOUND MIND IN A VULNERABLE BODY: PRACTICAL HARDWARE ATTACKS ON DEEP LEARNING"

(Hint: speaker is on the

In recent years ML models have worked from research labs to production, which makes ML security important. Adversarial ML research studies how to mess with ML

For example by messing with the training data (c.f. Tay which became super-racist super-fast) or by foiling ML models by changing inputs in ways humans can't see.


Prior work considers ML models in a standalone, mathematical way
* looks at the robustness in an isolated manner
* doesn't look at the whole ecosystem and how the model is used -- ML models are running in real hardware with real software which has real vulns!


This talk focuses on hardware-level vulnerabilities. This is particularly interesting because these can break cryptographic guarantees (because those are outside of their threat models)
e.g. fault injection attacks, side-channel attacks
SCIENCE
Michael Nielsen
Michael Nielsen
@michael_nielsen
What are the classics of the "Science of Science" or "Meta Science"? If you were teaching a class on the subject, what would go in the syllabus?

Here's a (very disorganized and incomplete) handful of suggestions, which I may add to. Suggestions welcome, especially if you've dug into relevant literatures.

1. The already classic "Estimating the reproducibility of
psychological science" from the Open Science Collaboration of @BrianNosek et al. https://t.co/yjGczLZ6Je

(Look at that abstract, wow!)


Many people had pointed out problems with standard statistical methods, going back decades (what are the best refs?). But this paper was a sledgehammer, making it impossible to ignore the question: what, if anything, were we actually learning from all those statistical studies?

2. Dean Keith Simonton's book "Creativity in Science: Chance, Logic, Genius, and Zeitgeist". If an essentially scientometric book could be described as a fun romp through science & creativity, this would be it
SCIENCE

You May Also Like

Ryan Caldbeck
Ryan Caldbeck
@ryan_caldbeck
1/ I am seeing more and more founder secondary in venture rounds (Secondary = founders selling some of their shares before some other shareholders are able). Series B-D. I see both as an investor and through entrepreneur circles.

2/ I like secondary for entrepreneurs. Moderation is key but in a lot of situations I think it helps accelerate the co. Lots of very smart investors disagree. Here are my thoughts.

3/ Magnitude: My basic rule of thumb from what I see is market is 4+ yrs and up to 10% of founder’s equity stake with some $ cap that makes sense given stage etc. (typically <$10m)

4/ The entrepreneurial journey is brutally hard. Giving some financial relief helps remove one piece of pressure. I don’t think that secondary in the magnitude mentioned impacts the drive/persistence of great entrepreneurs.

5/ That secondary means they will be able to just sleep knowing they can pay their kids’ tuition. Secondary will make most founders better at their jobs, thus accelerating the co.
ALL
\u0936\u094d\u0930\u0940\u092e\u093e\u0932\u0940 \u0939\u093f\u0924\u0947\u0936 \u0905\u0935\u0938\u094d\u0925\u0940
श्रीमाली हितेश अवस्थी...
@HiteshAwasthi89
Sri Adi Jagannatha Perumal Temple, Thiruppullani, TN

Thiruppullani village is located in Ramanathapuram district, It is located 62.3 km distance from Rameswaram. The main tourist attraction in Thirupullani is Sri Adi Jagannatha Perumal Temple....👇👇
@LostTemple7


This temple is mentioned in the Tamil classic devotional literature” Naalayira Dhivya Prabantham”, Thirumangai Azhwar sung a song on this place and the temple. and also Thiruppllai temple is referred in Valmiki Ramayana, Ramayana written by the great Tamil poet Kambar....👇


It is one of the 108 Divya Desam temples. Thiruppullani Sri Adi Jagannatha Perumal is also called as Sri Kalyana Jagannatha Perumal. It is believed that those who have difficulties or dhoshams regarding marriages and childbirth worship Jagannatha Perumal...👇
ALL
Advertisement
Will Buxton
Will Buxton
@wbuxtonofficial
The Haas / Force India argument is fascinating, and the decision of the stewards may still have consequences. The first key finding is that the stewards ruled Racing Point Force India to be a valid constructor. That means that it builds its own cars.

Haas had argued that the cars had been designed by Force India, but as Haas knows only too well, "outsourcing" is legal. The stewards decided that "there is no regulatory support for the argument that Outsourcing of Listed Parts cannot come from a former or excluded team."

In determining this, the stewards also came to the following conclusion: "In relation to the submission by the Racing Point Force India F1 Team that it is not a new team, the Stewards decide that the Racing Point Force India F1 Team is indeed a new team."

This will have a big knock on effect for Haas in its continued arguments over the rights of RPFI as relates to its eligibility and rights under the complex payments structure. Haas has argued all along that RPFI should be treated as a new team and tread the same path that it did.

TLDR? Haas lost the fight but may have won the war. In having its argument that Racing Point hadn't designed their own car thrown out, they gained clarification that RPFI was a new team.
SPORT
Mitesh Patel
Mitesh Patel
@Mitesh_Engr
How to sell option?
Here let me explain through simple math.
Say BN at 30000
30000 straddle trading at combine premium 800 ( based on current volatility)
Put at 400
Call at 400
You don’t know direction. Sold both.

If move will not come than both will decrease gradually.

At day end it will come down to 720-740 if move will not come. Difference is your profit.

Now case 2:
Move started.
At one points combine premium will start increasing.
Say 810.
Exit immediately. No need to do adjustment.
Let market settle.

Sell again straddle once market settle.
Now repeat same thing.

Straddle selling webinar over.
Good luck.

One can keep SL 550 for both strike to escape from sudden movement.
OPTIONSLEARNING , MITESHOPTIONS
foone
foone
@Foone
So there's a class of puzzles called "river crossing puzzles" which involve having to cross a river on a boat/bridge containing some set of individuals/items with restrictions on which ones can be on the boat/left on each shore, right?

and the most common subclass of these problems is the one where you have 3 items/animals to cross with.
This is alternatively called the "fox, goose, and bag of beans" or "wolf, goat, and cabbage" puzzle.

the idea is that your boat can only carry one item at a time, but if you leave the wolf/fox unattended with the goat/goose, the wolf/fox will eat the goat/goose.
and similarly, the goose/goat will eat the beans/cabbage if left alone

so you have to set up a set of actions that never leaves either side of the river in one of the lose-states.

the solution to this variant being:
1. take the goat/goose over
2. return empty
3. take the wolf/fox over
4. return with the goat/goose
5. take the cabbage/beans over
6. return empty
7. take the goat/goose over
GAMES