https://t.co/0BbPc11eTD
The Top 10 Psilocybin Research Papers of 2020
- FS Barrett, MK Doss, ND Sepeda, et al. – Emotions and brain function are altered up to one month after a single high dose of psilocybin. @FredBarrettPhD 1/10

SB Goldberg, BT Pace, CR Nicholas, et al. – The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis. “meta-analysis of studies using psilocybin along with behavioral interventions to treat elevated symptoms of anxiety and depression.” 2/10
GI Agin-Liebes, T Malone, MM Yalch, et al. – Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer. “follow-up approx 3.2 and 4.5 years later, w/ 15 of the 16 participants still alive” 3/10
F Blei, S Dörner, J Fricke, et al. – Simultaneous production of psilocybin and a cocktail of β‐carboline monoamine oxidase inhibitors in “magic” mushrooms “paper was chosen for Psychedelic Science Review’s 2020 Editor’s Choice Award for best study on psychedelics and nature” 4/10
J Sloshower, J Guss, R Krause, et al. – Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame “lays out how to combine therapy using antidepressant medication (like psilocybin) w/evidence-based psychotherapy” 5/10
LJMertens, MBWall, LRoseman, et al Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression
“↗️amygdala activation in participants day after psilocybin tx” 6/10
NL Mason, KPC Kuypers, F Müller, et al. – Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin. Good One! 7/10
MK Madsen, PMD Fisher, DS Stenbæk, et al. Single psilocybin dose is assoc. w/ long-term ↗️mindfulness, preceded by proportional change in neocortical 5-HT2A receptor binding
1st molecular neuroimaging study examining underlying mechanisms behind long term efx of psilocybin 8/10
KH Preller, P Duerler, JB Burt, et al. – Psilocybin induces time-dependent changes in global functional connectivity “deepen our understanding of the mechanism of action of psychedelic compounds” 9/10
N Milne, P Thomsen, N Malgaard Knudsen, et al. – Metabolic engineering of Saccharomyces cerevisiae for the production of psilocybin and related tryptamine derivatives 10/10 .... there are 4 more studies cited in the blog post.

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Hard agree. And if this is useful, let me share something that often gets omitted (not by @kakape).

Variants always emerge, & are not good or bad, but expected. The challenge is figuring out which variants are bad, and that can't be done with sequence alone.


You can't just look at a sequence and say, "Aha! A mutation in spike. This must be more transmissible or can evade antibody neutralization." Sure, we can use computational models to try and predict the functional consequence of a given mutation, but models are often wrong.

The virus acquires mutations randomly every time it replicates. Many mutations don't change the virus at all. Others may change it in a way that have no consequences for human transmission or disease. But you can't tell just looking at sequence alone.

In order to determine the functional impact of a mutation, you need to actually do experiments. You can look at some effects in cell culture, but to address questions relating to transmission or disease, you have to use animal models.

The reason people were concerned initially about B.1.1.7 is because of epidemiological evidence showing that it rapidly became dominant in one area. More rapidly that could be explained unless it had some kind of advantage that allowed it to outcompete other circulating variants.
Hi, I'm #MarvellousMarthy & this is a mini #GlobalScienceShow to celebrate @WomenScienceDay. I'd like to tell you about my STEM Role Model @MarineMumbles. Stick around for @philjemmett who’s up next. #WomenInSTEM #WomenInScience4SDGs #WomenInScience #girlsinSTEM


Go to
https://t.co/fAM7lPSznm to watch my film. I love Rockpooling now as a hobby & I have got Mummy & Daddy into it too. I have learnt loads about marine life over the last year & Elizabeth @marinemumbles has shared her ❤️ of the oceans with me. I LOVE crabs 🦀 🦀🦀!!

This is Gem, Marthy’s Mummy. There have been so many other STEM women who have truly inspired #MarvellousMarthy over the past year: @DrJoScience has ignited a love of experiments, @ScienceAmbass has brought giggles with some fab experiment-alongs, @HanaAyboob for introducing her

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So, as you can tell from the film, Marthy adores Elizabeth & is truly inspired by her. Since engaging with her for the first time about 10 months ago, Marthy has developed a very keen & passionate interest for all things Marine! The @angleseyseazoo can vouch for this!!!!

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