Recently I learned something about DNA that blew my mind, and in this thread, I'll attempt to blow your mind as well. Behold: Chargaff's 2nd Parity Rule for DNA N-Grams.
If you are into cryptography or reverse engineering, you should love this.
Thread:

The Review: GW 23 - A thread

Hi everyone, welcome to the latest edition of “The Review” where me and @urboihamza look ahead to the upcoming double GWs and chip strategies in detail:

#FPL #FPLCommunity @OfficialFPL

(Data taken from @FFScout and @FFH_HQ with consent)

Before I start, an update on the Fantasy5: There have been no winners for two consecutive GWs now, so I feel the organizers have been more sympathetic in setting targets yet again this week. This might be your best chance to win £10k! Link below:

At this point, I’d also like to mention that I post about FPL on my Instagram too, so if you have an Instagram account, do follow up here:

I’d like to dedicate this Review of mine to my dear friend Dylan who is an avid FPL player and a regular reader of my pieces. He is battling a brutal illness so my thoughts are with him and his family during these tough times – stay strong lil bro and good luck!

Q: What is the optimum strategy for FPL managers wildcarding sometime soon who do not have their Free Hit in hand?

I’d like to credit to @BenCrellin for his outstanding work helping to shed more clarity on the double GWs coming up. Southampton winning against Wolves...

Did you know that all the nuclear bombs we exploded in the '40s-50s-60s have permanently contaminated all the steel the world has produced since then? All steel in the world is divided into two categories: pre-1945 non-contaminated steel, and post-1945 contaminated steel.

How?

Nuclear bombs (including the tests) create a lot of radioisotopes that are not found in nature. For example Cobalt-60 (a radioactive version of Cobalt-59). And since the 1945 Trinity test, these have all dispersed in the atmosphere.

What does this have to do with steel?

The process of manufacturing steel uses atmospheric air (or atmospheric oxygen). Some of the radioisotopes like Cobalt-60 get pulled in too, and as a result, any steel produced after 1945 has embedded in it some of these radioisotopes, sitting there emitting gamma rays.

Why do we care about traces of radioisotopes in steel? When making Geiger counters, or medical devices to check for radioactive contamination, or astronomical instruments, the emissions from the contaminated steel would interfere with the measurements.

So we need pre-1945 steel

Pre-1945 non-contaminated steel is called "low background steel". And when we need it, where do we get it from?

We go, find pre-World-War-II sunken shipwrecks, and then salvage the steel (and lead) from those to build our instruments which need heavy radiation shielding.

1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.

The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.

2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.

3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.

4/ The stretching of the septum builds up an elastic tension in the septum, which is released as recoil, when tension declines in the lateral wall, showing a post systolic shortening in the septum which is due to elasticity.

Did we get dietary saturated fats all wrong? The #HADLmodel provides a new understanding and an opportunity to get it right. THREAD👇👇👇
@simondankel @kariannesve

Increased dietary saturated fatty acids lead to increased cholesterol in lipoproteins, but we don’t know why. Enter the #HADLmodel, which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that ensure optimal cell membrane fluidity and cell function.

We propose that circulating lipoproteins enable appropriate redistribution of cholesterol molecules between specific cells and tissues, to accomodate changes in dietary fatty acid supply, due to our omnivore nature and variable intake of fatty acids. #HADLmodel

Our #HADLmodel implies that circulating levels of LDL change for protective, not for pathological reasons; an SFA-induced raise in LDL cholesterol in healthy individuals is a normal response, while a lack of this needed response may reflect a deeper pathology in lipid handling.

Circulating lipoproteins may change for pathological reasons, when regulatory mechanisms become disrupted by pathogenic processes related e.g. to inflammatory processes. Diverging lipoprotein responses in healthy versus metabolically unhealthy individuals support this view.

In a number of Sunday papers:
Scientific advisers said it was “hard to see” when the restrictions would end as new variants continued to emerge, delivering a potentially devastating blow to the travel industry. The prime minister said that after progress with vaccinations...

...”what we don’t want to see is all that work undone by the arrival of a new variant that is vaccine-busting”.
The idea is planted in people’s mind that this virus is mutating in such a way as to evade prior immunity. This is completely unfounded, certainly as regards immunity..

...gained naturally, after repelling the virus (which well around 99.9% of the population do, fewer, obviously in the very elderly & already ill, more in those younger & well). It’s important to appreciate that upon infection, the human immune system cuts up an infectious...

...agent into short pieces. Each of these short pieces of protein are presented to other cells in the immune system, like an identity parade. Our cells have a truly astonishing range of abilities to recognise different protein structures, and there will be some which recognise...

...each of the pieces of the invader. The cells which recognise a piece are instructed to multiply selectively so that, after a few days to a couple of weeks, our bodies contain large numbers of virus piece specific cells. These have a range of functions. Some make antibodies...