- The NK cell proliferation ability declines with age: older people have a decreased ability to produce NC cells rapidly: https://t.co/VZ9PSW5OBU
(1/n) The important role of natural killer (NK) cells in COVID-19.
A summary of key insights:
- NK cells are cytotoxic lymphocytes & part of the innate immune system
- They play an important role in virus infection control & immunomodulation
- The NK cell proliferation ability declines with age: older people have a decreased ability to produce NC cells rapidly: https://t.co/VZ9PSW5OBU
- As early as June 2020, it was hypothesised that NCCs could be key in explaining severe COVID-19 courses: https://t.co/yJPXeXcku0
- Indeed, it was later found that NK cells from COVID-19 patients do not function well:https://t.co/aEK9KpaA45
- The activity of NK cells is downregulated by the cytokine transforming growth factor-β (TGFβ)
- Blood serum of patients with severe COVID-19 inhibits NK cell function in a TGFβ-dependent manner: https://t.co/aEK9KpaA45
- An untimely early production of TGFβ and associated NK cell dysfunction is a hallmark of severe COVID-19
- The inhibition of untimely TGFβ production & the promotion of NK cell function may positively affect SARS-CoV-2 control on multiple levels: https://t.co/zjeCnASWhx
- A lower NK cell count in COVID-19 patients has been shown to be correlated with a lower survival rate:https://t.co/EUQkL76GhW
- NK cell dysregulation as a key factor in COVID-19 was also highlighted 1.5 years ago: https://t.co/Dg0KmYT2iS
- “Restoration of NK cell effector functions has the potential to correct the delicate immune balance required to effectively overcome SARS-CoV-2 infection.”
- Vitamin D (our old friend!) also plays a role for the NK cells. Vitamin D deficiency correlates with a reduced number of NK cells in COVID-19 patients: https://t.co/YNrvKIrlgj
- While early NK cell stimulation & IFN-γ production is beneficial to combat infections, excessive & prolonged stimulation of NK cells leads to reduced NK cell numbers & an exhausted phenotype associated with increased systemic inflammation:
https://t.co/vPpfKbntne
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I just finished Eric Adler's The Battle of the Classics, and wanted to say something about Joel Christiansen's review linked below. I am not sure what motivates the review (I speculate a bit below), but it gives a very misleading impression of the book. 1/x
The meat of the criticism is that the history Adler gives is insufficiently critical. Adler describes a few figures who had a great influence on how the modern US university was formed. It's certainly critical: it focuses on the social Darwinism of these figures. 2/x
Other insinuations and suggestions in the review seem wildly off the mark, distorted, or inappropriate-- for example, that the book is clickbaity (it is scholarly) or conservative (hardly) or connected to the events at the Capitol (give me a break). 3/x
The core question: in what sense is classics inherently racist? Classics is old. On Adler's account, it begins in ancient Rome and is revived in the Renaissance. Slavery (Christiansen's primary concern) is also very old. Let's say classics is an education for slaveowners. 4/x
It's worth remembering that literacy itself is elite throughout most of this history. Literacy is, then, also the education of slaveowners. We can honor oral and musical traditions without denying that literacy is, generally, good. 5/x
As someone\u2019s who\u2019s read the book, this review strikes me as tremendously unfair. It mostly faults Adler for not writing the book the reviewer wishes he had! https://t.co/pqpt5Ziivj
— Teresa M. Bejan (@tmbejan) January 12, 2021
The meat of the criticism is that the history Adler gives is insufficiently critical. Adler describes a few figures who had a great influence on how the modern US university was formed. It's certainly critical: it focuses on the social Darwinism of these figures. 2/x
Other insinuations and suggestions in the review seem wildly off the mark, distorted, or inappropriate-- for example, that the book is clickbaity (it is scholarly) or conservative (hardly) or connected to the events at the Capitol (give me a break). 3/x
The core question: in what sense is classics inherently racist? Classics is old. On Adler's account, it begins in ancient Rome and is revived in the Renaissance. Slavery (Christiansen's primary concern) is also very old. Let's say classics is an education for slaveowners. 4/x
It's worth remembering that literacy itself is elite throughout most of this history. Literacy is, then, also the education of slaveowners. We can honor oral and musical traditions without denying that literacy is, generally, good. 5/x
👨💻 Last resume I sent to a startup one year ago, sharing with you to get ideas:
- Forget what you don't have, make your strength bold
- Pick one work experience and explain what you did in detail w/ bullet points
- Write it towards the role you apply
- Give social proof
/thread
"But I got no work experience..."
Make a open source lib, make a small side project for yourself, do freelance work, ask friends to work with them, no friends? Find friends on Github, and Twitter.
Bonus points:
- Show you care about the company: I used the company's brand font and gradient for in the resume for my name and "Thank You" note.
- Don't list 15 things and libraries you worked with, pick the most related ones to the role you're applying.
-🙅♂️"copy cover letter"
"I got no firends, no work"
One practical way is to reach out to conferences and offer to make their website for free. But make sure to do it good. You'll get:
- a project for portfolio
- new friends
- work experience
- learnt new stuff
- new thing for Twitter bio
If you don't even have the skills yet, why not try your chance for @LambdaSchool? No? @freeCodeCamp. Still not? Pick something from here and learn https://t.co/7NPS1zbLTi
You'll feel very overwhelmed, no escape, just acknowledge it and keep pushing.
- Forget what you don't have, make your strength bold
- Pick one work experience and explain what you did in detail w/ bullet points
- Write it towards the role you apply
- Give social proof
/thread
"But I got no work experience..."
Make a open source lib, make a small side project for yourself, do freelance work, ask friends to work with them, no friends? Find friends on Github, and Twitter.
Bonus points:
- Show you care about the company: I used the company's brand font and gradient for in the resume for my name and "Thank You" note.
- Don't list 15 things and libraries you worked with, pick the most related ones to the role you're applying.
-🙅♂️"copy cover letter"
"I got no firends, no work"
One practical way is to reach out to conferences and offer to make their website for free. But make sure to do it good. You'll get:
- a project for portfolio
- new friends
- work experience
- learnt new stuff
- new thing for Twitter bio
If you don't even have the skills yet, why not try your chance for @LambdaSchool? No? @freeCodeCamp. Still not? Pick something from here and learn https://t.co/7NPS1zbLTi
You'll feel very overwhelmed, no escape, just acknowledge it and keep pushing.
