(1/n) The important role of natural killer (NK) cells in COVID-19.
A summary of key insights:
- NK cells are cytotoxic lymphocytes & part of the innate immune system
- They play an important role in virus infection control & immunomodulation

(2/n)
- The NK cell proliferation ability declines with age: older people have a decreased ability to produce NC cells rapidly: https://t.co/VZ9PSW5OBU
(3/n)
- As early as June 2020, it was hypothesised that NCCs could be key in explaining severe COVID-19 courses: https://t.co/yJPXeXcku0
(4/n)
- Indeed, it was later found that NK cells from COVID-19 patients do not function well:https://t.co/aEK9KpaA45
(5/n)
- The activity of NK cells is downregulated by the cytokine transforming growth factor-β (TGFβ)
- Blood serum of patients with severe COVID-19 inhibits NK cell function in a TGFβ-dependent manner: https://t.co/aEK9KpaA45
(6/n)
- An untimely early production of TGFβ and associated NK cell dysfunction is a hallmark of severe COVID-19
- The inhibition of untimely TGFβ production & the promotion of NK cell function may positively affect SARS-CoV-2 control on multiple levels: https://t.co/zjeCnASWhx
(7/n)
- A lower NK cell count in COVID-19 patients has been shown to be correlated with a lower survival rate:https://t.co/EUQkL76GhW
(8/n)
- NK cell dysregulation as a key factor in COVID-19 was also highlighted 1.5 years ago: https://t.co/Dg0KmYT2iS
- “Restoration of NK cell effector functions has the potential to correct the delicate immune balance required to effectively overcome SARS-CoV-2 infection.”
(9/n)
- Vitamin D (our old friend!) also plays a role for the NK cells. Vitamin D deficiency correlates with a reduced number of NK cells in COVID-19 patients: https://t.co/YNrvKIrlgj
(10/n)
- While early NK cell stimulation & IFN-γ production is beneficial to combat infections, excessive & prolonged stimulation of NK cells leads to reduced NK cell numbers & an exhausted phenotype associated with increased systemic inflammation:
https://t.co/vPpfKbntne
(11/n) Phase 1 ⤑ Phase 2
(12/n)
- The vitamins A, B, C, D and E influence NK cell activity:
https://t.co/37ucftVsXp
(13/n) Also phytochemicals haven an effect on NK cell activity:
https://t.co/37ucftVsXp
(14/n) To summarize:
- NK cells play an important role in COVID-19 disease severity and outcomes
- Age, vitamin deficiencies, etc. negatively affect the functioning of NK cells
- Therapeutic approaches for COVID-19 should include support of NK cell function

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And here they are...

THE WINNERS OF THE 24 HOUR STARTUP CHALLENGE

Remember, this money is just fun. If you launched a product (or even attempted a launch) - you did something worth MUCH more than $1,000.

#24hrstartup

The winners 👇

#10

Lattes For Change - Skip a latte and save a life.

https://t.co/M75RAirZzs

@frantzfries built a platform where you can see how skipping your morning latte could do for the world.

A great product for a great cause.

Congrats Chris on winning $250!


#9

Instaland - Create amazing landing pages for your followers.

https://t.co/5KkveJTAsy

A team project! @bpmct and @BaileyPumfleet built a tool for social media influencers to create simple "swipe up" landing pages for followers.

Really impressive for 24 hours. Congrats!


#8

SayHenlo - Chat without distractions

https://t.co/og0B7gmkW6

Built by @DaltonEdwards, it's a platform for combatting conversation overload. This product was also coded exclusively from an iPad 😲

Dalton is a beast. I'm so excited he placed in the top 10.


#7

CoderStory - Learn to code from developers across the globe!

https://t.co/86Ay6nF4AY

Built by @jesswallaceuk, the project is focused on highlighting the experience of developers and people learning to code.

I wish this existed when I learned to code! Congrats on $250!!
1

From today, we will memorize the names of 27 Nakshatras in Vedic Jyotish to never forget in life.

I will write 4 names. Repeat them in SAME sequence twice in morning, noon, evening. Each day, revise new names + recall all previously learnt names.

Pls RT if you are in.

2

Today's Nakshatras are:-

1. Ashwini - अश्विनी

2. Bharani - भरणी

3. Krittika - कृत्तिका

4. Rohini - रोहिणी

Ashwini - अश्विनी is the FIRST Nakshatra.

Repeat these names TWICE now, tomorrow morning, noon and evening. Like this tweet if you have revised 8 times as told.

3

Today's Nakshatras are:-

5. Mrigashira - मृगशिरा

6. Ardra - आर्द्रा

7. Punarvasu - पुनर्वसु

8. Pushya - पुष्य

First recall previously learnt Nakshatras twice. Then recite these TWICE now, tomorrow morning, noon & evening in SAME order. Like this tweet only after doing so.

4

Today's Nakshatras are:-

9. Ashlesha - अश्लेषा

10. Magha - मघा

11. Purvaphalguni - पूर्वाफाल्गुनी

12. Uttaraphalguni - उत्तराफाल्गुनी

Purva means that comes before (P se Purva, P se pehele), and Uttara comes later.

Read next tweet too.

5

Purva, Uttara prefixes come in other Nakshatras too. Purva= pehele wala. Remember.

First recall previously learnt 8 Nakshatras twice. Then recite those in Tweet #4 TWICE now, tomorrow morning, noon & evening in SAME order. Like this tweet if you have read Tweets #4 & 5, both.