More from History
Thank you so much to the incredible @gregjenner and his team for having me on "You're Dead to Me" and to @kaekurd for being so hilarious and bringing Gilgamesh the restaurant into my life!
Hereโs a thread of some of the stuff referenced in the podcast for those interested
First of all, what even is cuneiform?
Itโs a writing system from the ancient Middle East, used to write several languages like Sumerian and Akkadian. Cuneiform signs can stand for whole words or syllables. Hereโs a little primer of its evolution https://t.co/7CVjLCHwkS
What kinds of texts was cuneiform used to write?
Initially, accounting records and lists.
Eventually, literature, astronomy, medicine, maps, architectural plans, omens, letters, contracts, law collections, and more.
Texts from the Library of Ashurbanipal, who ruled the ancient Assyrian empire when it was at its largest in the 7th century BCE, represent many of the genres of cuneiform texts and scholarship.
Hereโs a short intro to the library via @opencuneiform https://t.co/wjnaxpMRrC
The Library of Ashurbanipal has a complicated modern and ancient history, which you can read about in this brilliant (and open access) book by Prof @Eleanor_Robson
Hereโs a thread of some of the stuff referenced in the podcast for those interested
First of all, what even is cuneiform?
Itโs a writing system from the ancient Middle East, used to write several languages like Sumerian and Akkadian. Cuneiform signs can stand for whole words or syllables. Hereโs a little primer of its evolution https://t.co/7CVjLCHwkS
What kinds of texts was cuneiform used to write?
Initially, accounting records and lists.
Eventually, literature, astronomy, medicine, maps, architectural plans, omens, letters, contracts, law collections, and more.
Texts from the Library of Ashurbanipal, who ruled the ancient Assyrian empire when it was at its largest in the 7th century BCE, represent many of the genres of cuneiform texts and scholarship.
Hereโs a short intro to the library via @opencuneiform https://t.co/wjnaxpMRrC
The Library of Ashurbanipal has a complicated modern and ancient history, which you can read about in this brilliant (and open access) book by Prof @Eleanor_Robson
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in ฮฒ-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVฮฒ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in ฮฒ-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVฮฒ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs