🔥The unexpected consequence of too much sitting 🔥

The negatives of a sedentary lifestyle are widely known❗️

One issue that doesn't get mentioned enough is GLUTEAL AMNESIA, also known as the "dead butt syndrome".

Thread - Read more 👇

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GLUTEAL AMNESIA, also known as the "dead butt syndrome" simply means:

➡️ Your gluteal muscles have been "unused" for so long that they now fail to activate whenever your body needs them to
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Role of the Glutes:

➡️ Play a major role in the way our body moves

➡️ Not just there for aesthetics

➡️ Crucial for keeping our torsos upright, moving/rotating of the thighs & walking/running
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GLUTEAL AMNESIA ⁉️

➡️ Glutes get so weak that they forget to activate

➡️ Consequence: Other muscles need to compensate - such as your lower back muscles or hip flexors

➡️ This can cause all sorts of problems such as lower back pain, knee pain & poor posture
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How do you know if you suffer from the "dead butt syndrome"?

➡️Glute amnesia can vary in severity

Here's a simple test:

➡️ Do 10 glute bridges (video 👇)

🛑If you feel them more in your quads or hammies than in your glutes, you know you have some work to do.
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What can you do about it?

1. Choosing the right exercises

1⃣ Get off your butt (pun totally intended) & start focusing on your glute training

2⃣ Exercises like the squat, the deadlift & hip thrust are on top of the list

More from Health

Before we get too far into 2021, I thought I’d write a thread recapping some of the research that came out of my lab in 2020. Most of this work was led by my talented team of graduate students, Kerrianne Morrison, @kmdebrabander, and @DesiRJones.

Back in January, a news story was published about Kerrianne’s study showing improved social interaction outcomes for autistic adults when paired with another autistic partner.

A detailed thread about the study and a link to the paper can be found here (feel free to DM me your email address if you’d like a copy of the full paper for this study or any of our studies):


Another paper published early in 2020 (it appeared a few months earlier online) showed that traditional standalone tasks of social cognition are less predictive of functional and social skills among autistic adults than commonly assumed in autism research.


Next, @kmdebrabander led and published an innovative study about how well autistic and non-autistic adults can predict their own cognitive and social cognitive performance.
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Why can cefepime cause neurological toxicity?

And why is renal failure the main risk factor for this complication?

The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.

#MedTwitter #Tweetorial


2/
Let's establish a few facts about cefepime:

🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)

https://t.co/rjYG1BfGPR


3/
The first report of cefepime neurotoxicity was in 1999.

A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.

✅All symptoms resolved after hemodialysis.

https://t.co/u7JLVitQpp


4/
Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).

💡The main risk factors = renal failure and lack of dose adjustment for renal function.

https://t.co/nxbnzSq8AR


5/
What about cefepime induces neurotoxicity?

One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.

This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).

https://t.co/Lf4BhON9IY

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