BC HEALTH
Saved by @Mollyycolllinss

Sarcomeres in cardiac myocytes (heart muscle cells) are mechanically coupled to focal adhesions through dorsal stress fiber-like structures. #cardiotwitter #CellBiology
1/13
A thread based on Figure 1

 A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13
Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13
Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13
The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13
Another way of visualizing dorsal stress fibers. This montage steps through the edge of a myocyte in the Z dimension. Arrows denote individual dorsal stress fibers.
6/13
Another way of visualizing the paths of the dorsal stress fibers is by using a color overlay.
7/13
In non-muscle cells, dorsal stress fibers can mechanically couple adhesions to the substrate to stress fibers on top of the cell.
This led us to this hypothesis: dorsal stress fibers also mechanically couple focal adhesions and sarcomeres. But how to test it? Answer- LASERS!
8/13
If the contractile forces generated by the sarcomeres are balanced by attachment to focal adhesions, then we reasoned that cutting a dorsal stress fiber would result in the sarcomeres rabidly moving (i.e., snapping) away from the adhesions.
Enter: laser ablation.
9/13
Cutting a dorsal stress fiber did make the sarcomeres it was attached to move away from the edge of the cardiac myocyte. What? Don’t you see that it moved? Maybe we should look at it in a different—animated—way.
10/13
This gif shows just before (0s) and just after (2s) the dorsal stress fiber was cut. The movement of the sarcomeres was clear but subtle, so we sought to test the mechanical connection in another way.
Enter: cutting sarcomeres to test if dorsal stress fibers move.
11/13
If the sarcomeres and dorsal stress fibers are mechanically coupled, then cutting the sarcomeres should result in the movement of the dorsal stress fibers. It did.
Blue arrowheads show the dorsal stress fibers.
12/13
So what is the implication of the mechanical coupling between sarcomeres and dorsal stress fibers?
Our interpretation from 8 additional data figures: Strong coupling facilitates the maturation of sarcomeres. Weak coupling slows maturation down.
13/13
https://t.co/cKnT7wXo0w

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I think that a lot of people forget that OCD is a mental illness, emphasis on the MENTAL. When it’s portrayed on TV, it’s always shown as a very behavioral disorder. And while it’s true that overt behavioral compulsions are part of OCD, they don’t begin to tell the whole story

OCD stands for obsessive compulsive disorder. That’s obsessive thoughts and compulsive behaviors. The OCD cycle is the cycle of obsessions that lead to compulsions that lead to more obsessions that lead to more compulsions etc etc etc.

People with OCD experience intrusive thoughts (which become obsessions.) Intrusive thoughts are unwanted and invasive, and they’re generally REALLY disturbing. It’s a common misconception that people with OCD are exclusively concerned with tidiness and cleanliness. This is false

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First, the failure last year actually was driven by the White House, the #Trump inner circle. Watch what's happening now, the US' scientific and public health infrastructure is creaking back to life. 2/

I think Sam underestimates the decimation of many of our health agencies over the past four years and the establishment of ideological control over them during the pandemic. 3/

I also am puzzled why Tony gets the blame for not speaking up, etc. Robert Redfield, Brett Giroir, Deb Birx, Jerome Adams, Alex Azar all could have done the same. 4/

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Back in January, a news story was published about Kerrianne’s study showing improved social interaction outcomes for autistic adults when paired with another autistic partner.

A detailed thread about the study and a link to the paper can be found here (feel free to DM me your email address if you’d like a copy of the full paper for this study or any of our studies):


Another paper published early in 2020 (it appeared a few months earlier online) showed that traditional standalone tasks of social cognition are less predictive of functional and social skills among autistic adults than commonly assumed in autism research.


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I know some people who seem (to me) more concerned with receiving VALIDATION for their mental health issues than solving them.

They seem to care most about other people BELIEVING their problems are real.

I'm curious about this.

Like, it's more important to them that people know how debilitating their anxiety is, than to overcome the anxiety.

Or it's important to them that others believe that they're actually depressed, not "just sad."

Or they want people buy into the narrative that they've been traumatized, and might be something like offended if someone minimizes that.

What do we make of this?

1. One possibility is that if solving the problems seems hopeless or even just really hard, you need external support to be able to cope.

If no one cuts you slack because of your mental health stuff, maybe you're in a really bad place, so you need people to believe you.
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Spoke with my neighbour. A type 2 diabetic on medications and realized even now there is so much ignorance on this subject. I have done extensive research on this subject (was forced 2 after being diagnosed)

Here sharing it with you all. retweet it, it may save someone's life.

My Neighbour said his hba1c is 7. Everything is fine, he just needs to bring it below 6.9 and he would be fine.
That is just baloney! anything more than 5.6 will result in all kind of complications (Kidney failure,retina failure (blindness) amputations& heart attack etc etc

When i told him the benifits of intermittent fasting and fasting, My neighbour Nitin said, I cannot fast as doctor said i need to eat 5 -6 times a day.

FACT: If you are NOT on any insulin enhancing drugs. you can fast as much as you want. (metformin is OK)

to which he said These drugs r permanent & progressive, you can never stop using them.
FACT: if you can change your diet, you can change your sugar and insulin levels and no longer need these drugs. (advise not aplicable to type 1 diabetics, they wud always need insulin injection

Diet, I am on diet precribed by WHO.
FACT: Fuck WHO, and don't eat carbohydrates. infact another name of diabetes is carb intolerance. You can never acheive 5.6 or lower while eating your rice and roti.
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