If you’re frustrated by this lockdown it is worth remembering that there is an alternative. Our country has had a year to build an effective system for testing to identify cases & isolate them & those they have exposed. We are all paying the price for the failure to do this.

I've been seeing a lot of discussion around the dosage gaps recommended by government for the Astra/Oxford & Pfizer/BioNTech vaccines. My thoughts on the potential benefits & risks of such an approach, and the need for much greater transparency around these decisions. Thread.

The UK govt announced recently that both the Oxford & BioNTech vaccines would be now administered with a gap of between 4-12 weeks (so prioritise administration of first dose, given limited resources).

What is the basis of this?

The basis that's been discussed seems to be that
1) the first dose is likely to confer some degree of protection against disease, so better to roll this out as fast as possible, and
2) that for Oxford/Astra efficacy may be higher when the gap between doses is greater.

I discuss some of the technical details around the Oxford trial below for those interested in these. If you'd just like a summary of this, please skip to the summary tweet titled 'SUMMARY'.

What does published evidence show? The Astra/Oxford data are a bit messy because of protocol changes during the trial. This is because the trial was originally planned as a single dose trial, but a booster dose was added when developers realised that this would likely help.

Riley J. Williams is charged in the Capitol riot.
She allegedly stole a computer from @SpeakerPelosi’s office, & now @FBI is investigating a tip that she intended to send the computer to a friend in Russia who’d sell it to Russian intelligence.
Williams appears to have “fled”.

From the affidavit against her: Riley Williams’ former romantic partner called the FBI several times in the days following the riots to report that they had seen her in videos inside the Capitol, but friends of Williams had shown the tipster a video of Williams taking a laptop...

... computer or hard drive from Speaker Pelosi’s office. The witness told the FBI that “WILLIAMS intended to send the computer device to a friend in Russia, who then planned to sell the device to SVR, Russia’s foreign intelligence service...”

“... but that the transfer of the computer device to Russia fell through for unknown reasons and Williams still has the computer device or destroyed it. “This matter remains under investigation.”

Williams has appeared to have fled, she packed a bag & did not tell her mother where she was going but said she would be gone for a couple of weeks. She has changed her telephone number & deleted what are believed to have been her social media accounts on Facebook, Instagram...

Keir Starmer who worked with Theresa May as DPP said '“Whether you agree with her or you don’t, this was a woman broken who had tried to genuinely deliver on what she thought she had to do … I can’t pretend I didn’t feel something.”: #StarmerOut https://t.co/0NzX7Ouv2a

Sir Keir Starmer was elected as an MP for Holborn and St Pancras in 2015. Before that he worked with May as director of public prosecutions when she was home secretary. #StarmerOut #LabourLeaks #Collusion #CONLAB

May was someone who was always straight with him, who always phoned him to ask whether she could use something he had said. “A lot of politicians didn’t do that. She never double dealt. She said what she would do and she did what she said.” #StarmerOut #LabourLeaks

At the end of his term as DPP in 2013, she invited Sir Starmer to dinner at an Italian restaurant in Westminster to say thank you.
“It was a difficult 90 minutes. Both of us were pleased to see the hour and a half was up.” #StarmerOut #LabourLeaks

''Keir Starmer credentials as a former director of public prosecutions (2008 to 2013) placed Starmer a cut above the rest of Labour's frontbench in the eyes of many Conservatives.''. He became acquainted with several senior Tories.

Today, if Johnson bothers to show up for the impeachment trial, he’ll hear a flimsy defense of the indefensible. Then he faces an existential, character-defining choice: Country and Constitution, or party and personal power. We have a guess. But first, let’s review some clues.

Just a couple of days before the impeachment trial began, Ron Johnson said that there was “no reason” to hold the trial—and that barring Trump from ever holding federal public office again would “pre-emptively” disenfranchise people.

Ron Johnson knows something about disenfranchisement. In fact, he’s a big fan of it. He sought to disenfranchise millions of voters who chose Biden, spreading lies and fueling the fire of the January 6th insurrection.

He went on Fox News to claim there was voter fraud, that “millions of Americans have suspicions,” and made accusations about the validity of absentee

Johnson went on in that same interview to explicitly call for Congress to “delay accepting a particular state’s electors.” He announced that he was going to vote against accepting Arizona’s electors, feeding the fury of the Jan 6th insurrectionists.