BC FOR LATER READ
Saved by @CodyyyGardner

*puts on hard hat, respirator, asbestos gloves* (hey i haven't used these in awhile!)

okay. i'm seeing the same claims on my TL over & over that quite frankly, make no sense. & now they're starting to broken-telephone into each other so:

my thoughts on vaccine schedule.

 first off, let me get one thing across to start: this is not 2 doses v. 1 dose, it's 2 spaced 3-4 weeks apart vs. 2 spaced several months apart.
anyway, to begin: if you are reluctant to modify vaccine dosing schedule from the 3-weeks-apart one that we had in the Pfizer/BioNTech PhaseIII, *that's fine*. that's a legitimate reason.

but say just that. we know this works, we don't know about other regimes.
but for the love of all that is holy, please do not try to imply that this is a hard requirement, or optimal (imho, it likely isn't), or even *chosen for any reason other than being the shortest interval we could use to complete the PhIII ASAP*. that's it.
i'll be honest, i'm amazed 3 weeks *works*. it's shorter than *the shortest MINIMUM interval* for any other vaccine as scheduled according to, say, the CDC: https://t.co/rdb6TIHWPl
like, the whole point of a boost dose in a prime-boost vaccine schedule is to generate a *secondary* immune response.

primary seroconversion takes about 2 weeks (that's why the attack rate in the trials was still high then, then fell off a cliff).
three weeks in you've barely formed proper germinal centers, you quite likely will still hit the primary response quite often then.

as an aside, a few things that i keep hearing that further make no sense:
the "95% efficacy" or "70% efficacy" figure is a *population* efficacy figure.

it means that if 100 of you sign up for Tai-Tai's Cluster Dancing Lessons (so fresh you're guaranteed to go viral!), only 5 (or 30) of you will contract #COVIDー19 after attending.
it does *not* mean that *you yourself* have a 5% of contracting it, be it per exposure, or overall, or whatnot. there is no "partial immunity". you either seroconvert or you don't.

none of this is new, we've studied this extensively for MMR: https://t.co/zRf61T1qcO
we give a booster there (after *five years* typically!) not b/c one dose is "85% effective" for someone, it's b/c only about 85% of people seroconvert after one dose, & 97%+ after two.
fortunately we can easily check this for #COVIDー19 w/a Spike ELISA after 3 weeks. negative? boost then. otherwise...

i stand by this claim, even more strongly than before: https://t.co/5YlJNPGmLO
while i wasn't expecting this to happen this early or this catastrophically, *IT WAS GOING TO HAPPEN*.

we can yell at each other over what is optimal until we are blue in the face & we all hate each other for no reason, or...
...we can accept that we are in an out-of-control pandemic where there is, on average right now one person dying of #COVIDー19 somewhere in this world every *seven seconds*, realize that delaying doses is fundamentally not immunologically unsound, and therefore...
look, i get that clinical trials are hard. i really do. trust me on this. & i get that it's important to prioritize ones that are likely to produce results that are vitally important right now.
but i'd say when random world gov'ts are trying this sort of stuff w/o a trial, b/c the situation is so dire *the entire medical system is about to collapse in London right now*, your hand is a bit forced.

to say nothing of countries that can only afford 1 dose/person this year.
because guess what? immunologically it makes sense that it would work. in fact, it stands to reason (& it's interesting comparing the immunologists/vaccinologists on my TL to the virologists) that it will work *better*.
and if everyone's fears are realized & it doesn't? well here's some nice hard data to stop anyone else from trying this, from very early on in the world vaccination schedule, that's a heck of a lot more convincing if you need to stop someone like BoJo.
a few final asides: if you seroconvert & class-switch to IgG that means you've had a T_{FH}/B-cell germinal center response, which means that yes, you have developed memory B cells to that antigen. which survive decades.
i don't understand why i still keep hearing the whole "immunity fading" argument (and after TWELVE WEEKS?!? please show me an example of that in the literature, i tried really hard to find that the past two days w/no success).
i thought after @jbloom_lab demonstrated that reinfection to HCoVs was due to *antigenic drift* & not like when CoV-specific memory B cells inexplicably decide to take a vacation that year, i'd stop hearing that repeated so often...
...particularly when it does not work this way for any other of our vaccines that are currently on the market.

some references: https://t.co/muK3HQdgJ6 / https://t.co/muK3HQdgJ6 / https://t.co/4K4Bafimvm / https://t.co/RdckhYyksv / https://t.co/bV2We9NFN8
https://t.co/BNr7KXTiOS / https://t.co/jYownNFueX / https://t.co/CrNreAMbdl / https://t.co/25XdiivC5g

More from For later read

Kirsti Miller
Kirsti Miller
@KirstiMiller30
@FionaPearman @ScottMorrisonMP Morrison is our statue of unempathic neoliberalism - erected by evangelical and corporate Australia to celebrate their victory over compassion, equality and secular humanism. 

Hopefully it gets pulled down like the statues of dubious heroes of oppression from an earlier age.


@ScottMorrisonMP The two-party-preferred system in 
Australia politics isn’t working for people, and it sure isn’t working for the planet.

@ScottMorrisonMP My collapse of faith in our democracies isn’t an accident. It’s one of the central victories of the neoliberal project, delivered through two generations of privatisation, outsourcing and deregulation, underfunding of government services (locked in by tax cuts),...

@ScottMorrisonMP restricting freedom of information, targeting whistleblowers and raiding the media who report on them, delegitimising and gagging public interest advocacy, and criminalising protest.

@ScottMorrisonMP Politics in Australia today relies hugely on the fact that most people don’t know most of what’s going on so as to get away with stuff that couldn’t be done under real scrutiny we have seen a clear example of this with the National Coronvirus Cabinet.
FOR LATER READ
Enigma
Enigma
@ainittomai
On December 25 Mr Pool retweeted August 16 message about the Phoenix and that the worst was still on the horizon to come. 1/*


Maybe now we can assume that November 3 message meant "FUD" nor "FUN". Putting the word in capital letters seems to indicate the aspect the word fud has in our space, FUD. 2/*


Brad started it on December 22 (1/3 posts (Don't say? Sure) = 13 = Plan B). 3/*


And immediately the SEC followed dropping the bomb (1.3 billions (Don't say? Sure) = 13 = Plan B). 4/*


FUD materializes, Bitstamp is one of the first that haltes XRP trading and so on. 5/*
FOR LATER READ
Advertisement
Defense News Nigeria
Defense News Nigeria
@DefenseNigeria
The people can always be brought to the bidding...tell them they are being attacked, and denounce the naysayers for lack of patriotism and exposing the country to danger.

Hermann Goring

We've seen reports of Yoruba leaders asking President Buhari to stop the war and sack service chiefs immediately as a way of beginning restructuring.Our country is sitting on a keg of gunpowder they claim. Once again partisan hacks want to snatch victory from the jaws of defeat.

You see, when you are fighting small limited wars there is a natural inclination , on the part of politicians not directly impacted by the war to want to blow things out of proportion. There is a basic disconnection now in this country between the population and the war

....and i find it quite frankly. Frightening. Compared to what was obtainable 2015, the security situation in Nigeria has vastly improved yet the media ..and partisan hacks portray a much more pessimistic narrative.

Consider that in 2015 over 21 Local government areas and 2.6 million Nigerians were cut off from the rest of the country, under the administration of a caliphate in Nigeria for 16 months. A huge chunk of the northeast was no mans country.
FOR LATER READ
Jared Rubin
Jared Rubin
@jaredcrubin
Excited we finally have a draft of this paper, which attempts to provide a 'unifying theory' of the long economic divergence between the Middle East & Western Europe

As we see it, there are 3 recent theories that hit on important aspects of the divergence...

1/


One set of theories focus on the legitimating power of Islam (Rubin, @prof_ahmetkuru, Platteau). This gave religious clerics greater power, which pulled political resources away form those encouraging economic development

But these theories leave some questions unanswered...
2/

Religious legitimacy is only effective if people
care what religious authorities dictate. Given the economic consequences, why do people remain religious, and thereby render religious legitimacy effective? Is religiosity a cause or a consequence of institutional arrangements?

3/

Another set of theories focus on the religious proscriptions of Islam, particular those associated with Islamic law (@timurkuran). These laws were appropriate for the setting they formed but had unforeseeable consequences and failed to change as economic circumstances changed

4/

There are unaddressed questions here, too

Muslim rulers must have understood that Islamic law carried proscriptions that hampered economic development. Why, then, did they continue to use Islamic institutions (like courts) that promoted inefficiencies?

5/
FOR LATER READ
GAVNet
GAVNet
@GAValueNetwork
Daily Bookmarks to GAVNet 02/20/2021
FOR LATER READ

You May Also Like

Hindu Media Wiki
Hindu Media Wiki
@HinduMediaWiki
Speech Delay is most common in children nowadays

In ancient times, our grandparents used to follow typical natural way of caring the needs of a child. All they used were more of natural products than chemical based for the growth of child.


One of major step followed was to feed Gurbach Jadd/ Vasa Kommu/ Acorus Calamus for initiating good speech ability in a child. This stem was needed to babies on Tuesdays and Sundays in mother's milk.

Vasa is feed to baby after the 1st bath on 12th day in week. Weekly only thrice it is fed and named as :

Budhwar - Budhi Vasa
Mangalwar - Vaak Vasa
Ravi Vaar - Aayush Vasa

This stem is burnt and rubbed against the grinding stone in mother's milk or warm water to get a paste


The procedure to make it is in the link

https://t.co/uo4sGp7mUm

It should not be given daily to the child. Other main benefits are

1. It clears the phlegm in child's throat caused due to continuous milk intake. It clears the tracts and breathing is effortless.
2. Digestion

For children who haven't got their speech and is delayed than usual should feed this vasa on these days in week atleast for 6months. Don't get carried away with this dialogue
"Some gain speech little late"
CHILDREN
Jaya_Upadhyaya
Jaya_Upadhyaya
@Jayalko1
HORANADU ANNAPOORNESHWARI, CHIKMAGALUR (KAR)
#bharatmandir

Annapoorneshwari is the Devi of nutrition and food. The literal meaning of Annapoorneshwari is “Feeding one and all”. Anyone who comes here is offered meals and shelter within the premises.
@LostTemple7


Maharshi Agastya is believed to have done pratishtha here.

Once, Shiva and Parvati had an argument. Shiva declared everything in the world including food to be Maya or illusion. To prove him wrong, Devi Parvati disappeared resulting in entire Earth becoming still.


Taking pity, Devi appeared as Annapoorna and relieved everyone.
Another belief is that once Shiva beheaded Brahma and his skull got stuck in Shiva’s hand. He was cursed that till the skull is not full of food or grains, it will remain stuck to his hands.


Shiva went everywhere and asked for food but the skull was never full. He finally came here and Maa Annapoorna filled the skull with grains and reversed Shiva’s curse.

It is believed that who ever visits Devi Annapoorna here will never be without food in their lives.
ALL
Advertisement
Suhas S. Hardutt
Suhas S. Hardutt
@HarduttSuhas
THE BATTLE OF PRATAPGARH (10 Nov, 1659)

Chhatrapati Shivaji Maharaj's impeccable military genius and matchless courage humbled the Adil Shahi Sultanate.

The beginning of what was to come later for the M0ghuls from one of the most indefatigable defenders of Dharma!

(Thread)


Shivaji’s growing influence in Maval region, made him a threat to the Adil Shahi ruler of Bijapur who sought to restrain him. The man who was given the responsibility of this mission, was their commander, Afzal Khan. Afzal was a formidable warrior known for his ruthlessness.(1)

His strategy was to bring Shivaji out into the plains, where he held an advantage, compared to the rocky Deccan terrain. Afzal attacked the holy town of Pandharpur, and later demolished the temple of Bhavani at Tuljapur to instigate Shivaji in a bid to bring him out.(2)

Shivaji was angry but remained patient. Knowing that he could not defeat Bijapuri Sultanate in an open battle, Shivaji moved to Pratapgarh fort, located on rocky heights, surrounded by thick forests of Jawali.(3)

This set the pattern for future Maratha attacks, using guerrilla warfare against larger invading armies rendering them ineffective in unfavorable terrain.(4)
HISTORY
Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)

@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice


@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2


@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj


@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
ALL
\u0936\u094d\u0930\u0940\u092e\u093e\u0932\u0940 \u0939\u093f\u0924\u0947\u0936 \u0905\u0935\u0938\u094d\u0925\u0940
श्रीमाली हितेश अवस्थी...
@HiteshAwasthi89
Varahi Amman, Madurai, Tamilnadu

Vaarahi is one of the Saivite Shakti deities with the group of goddesses known as SAPTAMATAS.
They are: Brahmi, Maheshwari, Kaumari, Vaishnavi, Vaarahi, Mahendri and Chamundi. 1/n


They are the Shakti (female) equivalents of their male counterparts. Vaarahi is the Shakti of Bhairavar who is one of the Amsam of Bhairavar.Created from the boar avatara of Vishnu, Vaarahi is often associated with Goddess Kamala (one of the Mahavidyas). 2/n


She is also called Dandini (Lady Commander of the forces of the Mother-Goddess, symbolizing the might of SriVidya). As Vaarahi ("hog-faced" or "the great consumer") she destroys evil forces that obstructs the devotees' progress, paralyses the enemies 3/n


and led the devotees ultimately to SriVidyas. She is also called Panchami). With Kurukalla, she is accorded the parental status to Sri-Chakra (Lalita Tripura-Sundari). While Kurukalla represents the full moon, Vaarahi represents the new-moon. 4/4

Jai Maa Varahi 🙏


Tag for 📷 credit
ALL