It’s always fun to guess what would happen next year, no matter how wrong we would be.
Below is my 2021 crystal ball – out there to be smashed :)
A thread to come.
a) Bitcoin price hitting $100k
b) More momentum in developer sponsorship
c) Lightening getting beyond early adoption
d) Payment in bitcoin gaining more traction (Africa and LatAm)
e) More smart contracts built on top of bitcoin network
Will some small countries PUBLICLY load up bitcoin as part of their forex reserve?
a) Reg tightening continues in western world
b) DeFi vs CBDCs (key word: censorship & nationalism)
c) Self-hosted wallet ecosystem starts to flourish
d) >5 out of top 10 tokens are DeFi tokens
e) Ethereum still dominates; 2-3 competing chains closing the gap
a) With bitcoin more mainstream, comes the first crypto M&A wave
b) Finger-crossed for at least one crypto IPO that could further drive awareness
c) The heart (and future) of crypto community is still with decentralized crypto projects with native token
d
d) Investments more than double in crypto projects, driven by bitcoin bull + DeFi run + remote lifestyle post COVID
e) Shall we expect a NFT season in 2021? – Entertainment and social may start to see more scalable crypto use cases
More from For later read
https://t.co/w7koHyMJjL
The article mentions a “10 nucleotide linker” (GCAUAUGACU) in the poly-A tail. This is described in the patent link below (Modification of RNA, producing an increased transcript stability and translation
Here is a link to the full mRNA code if you wish to download it, blast it or make up a batch in your garage
The mRNA sequences used for Moderna mRNA-1273 & Pfizer BNT162b2 mRNA vaccines for COVID-19 (Direct link in Word Format). WHO International Nonproprietary Name Program # 11889 "Messenger RNA encoding the full-length SARS-CoV-2 spike glycoprotein"https://t.co/zTb7B0Apic pic.twitter.com/8tZxAZWI5S
— Roland Baker (@RolandBakerIII) December 24, 2020
An overview of the encoded spike
Moderna's mRNA-1273 & Pfizer's BNT162b2 consist of mRNA 3821 nucleotides long encoding *all* 1273 amino acids of the Spike including a 2 Proline-stabilized RBD and this includes the NTD (blue in monomer, dark gray in trimer attached to antibodies). AA 64, 66, 187, 213, 214 red. pic.twitter.com/4MX1ByAsrR
— Roland Baker (@RolandBakerIII) December 19, 2020
Initial mouse
News: NIH-Moderna investigational COVID-19 vaccine shows promise in mouse studies https://t.co/7JYuUyZT45
— NIH (@NIH) August 5, 2020
How do I know they have NDAs, if they can't talk legally about them? Because they trusted me with their secrets... after I said something. That's how they knew I was safe.
And if the environment at the org was toxic or abusive, it is not uncommon to not realize the extent of that toxicity/abuse until after you're out. But by the time you realize that you signed under duress and presumed good faith where none existed, you're out of options.
— Lauren Thoman (@LaurenThoman) February 16, 2021
Some of the people who have reached out to me privately have been sitting with the pain of what happened to them and the regret that they signed for YEARS. But at the time, it didn't seem like they had any other option BUT to sign.
I do not blame *anyone* for signing an NDA, especially when it's attached to a financial lifeline. When you feel like your family's wellbeing is at stake, you'll do anything -- even sign away your own voice -- to provide for them. That's not a "choice"; that's survival.
And yes, many of the people whose stories I now know were pressured into signing an NDA by my husband's ex-employer. Some of whom I *never* would have guessed. People I thought "left well." Turns out, they've just been *very* good at abiding by the terms of their NDA.
(And others who have reached out had similar experiences with other Christian orgs. Turns out abuse, and the use of NDAs to cover up that abuse, is rampant in a LOT of places.)
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1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o