That is not the case! My problem with sarcasm is that it's not actually funny.
That is not the case! My problem with sarcasm is that it's not actually funny.
But this joke is not at all sarcastic.
"Are you going to Johnny’s party?"
"Nooo, I’m going to be a total loser and stay home."
This is sarcasm (accompanied by a laugh track):
https://t.co/zTmo911V9N
It\u2019s always just a cheap shot disguised as humor. Occasionally it\u2019s done well - majority is just meanness. Prov 26:18,19 Like a madman who shoots fiery missiles, arrows, and death* 19 Is the man who plays a trick on his neighbor and says, \u201cI was only joking!\u201d
— WesternWalking (@westernwalking) February 20, 2023
Guy 1: Oh, you're painting your fence today?
Guy 2: No, I'm milking cows on jupiter, while drinking light soda and driving.
Guy 1: Was that sarcasm?
Guy 2: Now, why would you think that?
https://t.co/uKtX4Huz42
What this culture thinks is smart:
— Andrew Algra (@AndrewAlgra) February 19, 2023
Saying the opposite of what you mean.
What is smart:
Saying what you mean.
Snark is not a substitute for wit.
https://t.co/zDPhglJbFj
A large part of this modern irony and sarcasm are a poison in our veins. It makes people act like twats and then they mock anything serious while being completely unfunny.
— C\U0001f90dMFY (@AhComfy) February 20, 2023
But this is obviously far from ideal, and even then these tools should be used with caution.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs