CodyyyGardner Categories Government
There’s much debate around the UK's recommended use of the AZ vaccine with a two-dose schedule and flexible timing of second dose. Some thoughts on the AZ recommendation (not Pfizer) based on available data with refs to some excellent threads.
1. It's a real pity the UK drug regulator, MHRA, doesn't hold public advisory committee meetings to assess #Covid vaccines, in the way @US_FDA does. Would have been fascinating to listen to a detailed analysis of the AstraZeneca-Oxford vaccine's emergency use application.
— Helen Branswell (@HelenBranswell) December 30, 2020
Thread
UK’s MHRA and JCVI are highly-experienced in vaccine assessments and recommendations, and they've surely weighed the benefits & risks of this recommendation carefully. That said, it would be good to see all the data underpinning their recommendation.
AZ\u2019s new claim is that they achieve 95% efficacy by increasing dose interval to 3 months. I see no efficacy data to support it in the new UK approval but it appears true that immunogenicity is much higher with that regimen (antibody titer nearly 3x higher than short interval) pic.twitter.com/ZtxSPjHUot
— Ed MD (@notdred) December 30, 2020
In general, vaccines should be taken on a schedule tested in an efficacy trial. But it wasn’t possible to conduct the typical dose and schedule optimization prior to these Ph3 trials, and those trials provided valuable data to inform these recommendations. 3/
The UK recommends a two-dose schedule, with the second dose between 4-12 weeks. This *is not* a single dose schedule. Given the data provided, and in the setting of limited supply, overstretched hospitals, and emergence of a more transmissible variant, this seems justifiable. 4/
The UK has important data on the AZ Vx that wasn’t available for Pfizer & Moderna at FDA's VRBPAC, including:
* single-dose efficacy through 4+ months; and
* single-dose immunogenicity (12+ weeks).
I've been seeing a lot of discussion around the dosage gaps recommended by government for the Astra/Oxford & Pfizer/BioNTech vaccines. My thoughts on the potential benefits & risks of such an approach, and the need for much greater transparency around these decisions. Thread. pic.twitter.com/mclqMDeMQ1
— Deepti Gurdasani (@dgurdasani1) December 31, 2020
Belarus president Alexander Lukashenko authorised political murders in Germany in recent years, according to a bugged meeting of his former spy-chief. https://t.co/XWoiaemvuv
— EUobserver (@euobs) January 4, 2021
Tape doesn't prove Belarus killed Sheremet but adds new wrinkle to unsolved case & weight to one of 3 "tracks" of investigation: organized & carried out by Russians; ...Ukrainians; ...Belarusians. Details about how KGB wanted Sheremet killed also similar to what really happened.

Ukraine arrested and is currently trying 3 suspects in Kyiv for Sheremet's murder. All have denied involvement and much of Ukrainian civil society has sided with them. Legal experts also say authorities' case is built upon weak evidence. I wrote about it:
I've covered the Sheremet murder from day one. I wrote a lengthy investigation about it for @pressfreedom in 2016-17: https://t.co/fFr4bAJdEy I found many failings on the part of Ukrainian authorities, who made their preference clear from the beginning: that Russia was behind it.
Another investigation into Sheremet's murder by @OCCRP and @Slidstvo_info also found failings in the official investigation as well as possible links to Ukrainian security service involvement.
Mike Pence @vp @mike_pence is disloyal to @realDonaldTrump. Mike is also a traitor to We The People.
— Lin Wood (@LLinWood) January 4, 2021
Mike is a good friend to CCP. Too good.
I don\u2019t trust Mike Pence at all. Do you?https://t.co/6NTUl3PDeq

1. Their stunt on Jan. 6 will fail. What happens after objections are raised to a state's slate of electors in both the House and the Senate, is that they each have to debate the issue and then vote. It can't take more than 2 hours.

The House has a Democratic majority, so there's zero chance that a state's electors will get thrown out. (Both the House and the Senate have to agree.) All this is, is political theatre and as such, it'll get a lot of attention and make Trump happy.

You don't have to take my word on this. Read @Teri_Kanefield's explainer here:
I'll lay the entire process out here, and show why this can't happen. Applicable law: The Electoral Count Act and of course, your favorite document and mine, the Constitution, or, if you prefer cliff notes: https://t.co/cWXMlHiVvd
— Teri Kanefield (@Teri_Kanefield) December 12, 2020
Here's what happens on Jan. 6.
1/ https://t.co/pZziPKR0km
2. So the obvious question is, if this stunt is doomed to fail, why in the world are these Republicans doing this?
Contrary to what this looks like, it's not about their fealty to Trump.

(2) Made at 4.30 pm today, laid before Parliament at 5.30 pm, published on https://t.co/ZtYk9EHWsF at 5.44 pm, come into force at 00.01 tomorrow, 6 Jan.

(3) As predicted they tweak the rules for Tier 4 and put the whole country into it - so just a mere 5 pages to do this
(4) So, some specific changes - on the restriction of movement, which prohibits leaving / being away from home without a reasonable excuse, the following circumstances which are deemed to be a reasonable excuse are deleted...
(5) recreation, visting a zoo etc is out

Government virus expert paid £116k by swine flu vaccine manufacturers.
"The 'false' pandemic: Drug firms cashed in on scare over swine flu, claims Euro health chief."
January 2010.
https://t.co/nDs2ifa6jk

The 2016 simulation of a pandemic found holes in the UK’s readiness for such a
November 2018
"Ineffective flu vaccine added to 50,000 extra deaths last winter. Office National Statistics."
"Human suffering and lost lives over winter 'predictable, preventable and
But American institutions are strong in significant part because we don't let politicians act like Donald Trump, particularly not when they get close to the white house. It's not a law of nature; it's something we're actively doing. If we stop doing it, we lose our immunity.
— Megan McArdle (@asymmetricinfo) January 8, 2021
My right-wing followers, of course, understand why this won't fly: America borrowing in dollars, and under US law rather than some neutral third country, is not a law of nature. People with money could easily decide it was too risky to make us dollar-denominated loans.
(Or at least, at any price we'd want to pay.)
What would make them decide this? The fastest way would be for America to borrow a metric crap ton of money, and then default or let inflation eat away the value of our loans so we're repaying pennies on the dollar in real terms.
And since the "America can't have Greek-style debt crisis" talking point is genreallly only uttered by people who are urgin gus to do exactly the sort of thing that make it more likely we'll have trouble borrowing money in dollars, this is just deeply, deeply silly.
I mean it would probably work for a while--as Adam Smith said, "There's a lot of ruin in a nation". I am prepared to concede that the natural stopping point of this binge might be quite a few years away. I only say there is some stopping point.