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It is very hard to write the mission after the fact. You should start with a clear reason to exist and filter early hires for believers.
1/ What is \u201cproduct/market fit\u201d? I\u2019m not sure I can give you a definition. But maybe I can share what the subjective difference is in how it feels when you have it and when you don\u2019t. Founding a startup is deciding to take on the burden of Sisyphus: pushing a boulder up a hill.
— Emmett Shear (@eshear) July 27, 2019
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz