BC SOCIETY
Saved by @CodyyyGardner

Modellers believe that spreading out our limited supply of vaccine as single doses for 3 months will save up to 6000 lives. One concern though is whether single doses might lead to 'vaccine resistance' through virus mutation. (1)

 If we assume that over the next 12 weeks 12-20 million people get one dose of a vaccine and are told or believe it gives 90% protection what % will actually go for a second jab? We might assume second dose coverage is at best 70%. (2)
That means between 4 and 6.7 million people might have fading protection. Will the risk of creating a vaccine resistant mutant in this group of people, which could spread rapidly to 7 billion people around the world, outweigh the benefits of 6000 deaths prevented. (3)
I was initially reassured by a paper sent to me by an eminent virologist. https://t.co/UyTQZ0CFsW (4)
Essentially vaccine resistance is rare compared with drug resistance, first because multiple mutations are needed unlike for drugs, and second because vaccines tend to keep pathogens from ever achieving large population sizes within hosts. (5)
Nonetheless, vaccine resistance has been found with hepatitis B, whooping cough (B.pertussis, Strep. pneumoniae and other viruses, although these strains may die out through low transmissibility. (6)
Now I've read an excellent thread on the topic by a paediatrician and evolutionary geneticist. He refers to a study where the virus needed only 3 mutations to escape death from plasma full of neutralising antibodies. https://t.co/F5niMgZtlI.
He concludes: "The longer SARS-CoV-2 is in circulation, + the greater the number of people infected, the more of a chance escape mutants will have to form...and imperil the unprecedented efforts put into vaccine development". (7)
I've also been sent another highly technical paper about Covid mutations. https://t.co/5mzevEUh40 (8)
The paper concludes that "Widespread transmission of an emerging pathogen, such as SARS-Cov-2 can potentially lead to further mutations that affect transmissibility or effectiveness of countermeasures." (9)
The take home message is that where transmission remains high, viral mutations are more likely, which could change transmission rates, virulence or induce vaccine resistance. (10)
Giving single doses of vaccine might be fine in China, Taiwan or Norway, or any of about 70 countries with low transmission rates. But up to three million people in the UK may be infected, so the risks of mutations and vaccine resistance are much higher (11)
We've already seen a variant which appears to increase transmission by 50% or more. The difficult choice is between saving 6000 lives with a single shot policy and the risk of creating a vaccine resistant variant that could quickly cross borders. (12)
Whatever we decide, the message is that suppression of the virus must be at the centre of national strategy, not 'flattening the curve' which has, bizarrely, been official UK policy and advice since February 2020. (13)

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Hey folks, have you ever wondered why trans people face constant accusations of fetishism, sexual predation and child abuse/grooming? Well, today let's talk about stochastic terrorism.

So, first we have to talk about what stochastic terrorism actually is. Remember when there was a conspiracy that there was a pedophile ring operating out of a pizza parlour basement, and a crazed gunman showed up? It's that sort of incitement that stochastic terrorism describes.

It's the demonisation or incitement against a group of people or individuals with the intent that other, unaffiliated parties will act upon it; it's the releasing doctored footage and a shooter show up at Planned Parenthood as a direct result of what he's been led to believe.

So with that in mind, let's talk about Russia's extreme anti-LGBT laws that banned the "promotion" of LGBT lifestyles to children. A move that specifically marked LGBT people as a threat to children, and resulted in neo-nazis meting out vigilante "justice" against gay men.


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Today, there are 500,000 young men missing from the U.S. workforce.

Research suggests video games & improved leisure tech plays a role in the problem. 👇 Thread:

Following the 2007 to 2009 recession, 25 to 34 year old men exited high school with fewer middle-skill job opportunities than years prior.

During this time, we saw an increased number of men living with parents & choosing unemployment over lower paying jobs.

It's estimated that 24M millennials live w/ their parents.

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What's more surprising? 9 in 10 who lived with their parents a year ago are still living there w/ no plans to leave.

Economists are calling millennial men a lost generation.

According to economist David Dorn:

“If you get to the point where you’re turning 30, you’ve never held a real job and you don’t have a college education, then it is very hard to recover at that point.”

Economists suggest this choosiness is a generational trait.

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Recently heard the podcast by @sikhyaent on Saravana Bhavan founder P Rajagopal, who stalked the young daughter of an employee & had her husband killed. Observations: the podcast's title ('Dosa King') glorifies PR, the script trivialises his crime, calling it a mere "scandal"

It refers to the whole stalking and murder episode as something that led to Rajagopal's "fall" - i.e a story of crime against a woman is turned into a story about the impact of the said crime on its perpetrator, not its victim.

It refers to the stalking victim as a fit antagonist for the protagonist Rajagopal, as Rajagopal's nemesis. But the point is, she set out to be neither. She didn't make him part of her life story. He forcibly, violently disrupted her life.

The podcast ends by telling us how Rajagopal's employees and friends and many others abuse the woman he stalked, for pursuing the case of her husband's murder and bringing Rajagopal to justice. It also tells us that some admire her. And it "asks us to decide" where we stand

I find it disturbing that a story of a powerful man feeling entitled to ruin a woman's life & trying to get away with murder, is turned into a story of HIS "rise, popularity, and fall".
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A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

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...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

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While main deity is Shiva as Kapartheeswarar, the kshetram is famous for Ganesha, known as Swetha/Vellai Vinayagar (white Vinayak)

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