AGI Significance Paradox: As progress accelerates towards AGI, the number of people who realize the significance of each new breakthrough decreases.

The interview with CNBC of @chamath is a much watch because there is so much insight hidden underneath.

There are many things that caught my attention. The one thing was the abstraction that hedge fund strategies are all 'momentum' plays. What it seems to imply is that the marshaling of resources at an opportune time drives the future behavior of a stock.

From basic physics, we know that momentum is mass times velocity. So any 'momentum' tactic employs the variation of mass, velocity or both. Wrt stocks, mass is money and velocity is speed of trade.

We cannot argue that there are benefits of scale associated with having more money. Also, high-frequency trading has shown the value of high-speed trading. So in an abstract sense, market manipulation can involve a kind of momentum play.

The objective of stock trading is to buy a financial instrument at a low price and sell it at a higher price. The purpose of a momentum play is to front-run the decision process of other traders such that one acquires the assets before a decision is made.

Abduction is that thought process where we renew our past, question our present, and reimagine our future.

It was C.S. Peirce, a century ago, that coined the use of this term to describe a thought process that would convey hypothesis making.

A little over 50 years ago, proponents of Artificial Intelligence, proposed that deduction would be the core feature of human intelligence. This idea was driven by the bias towards formal logical systems and the emergence of computers.

This approach was in stark contrast to cybernetics (introduced a decade early) that proposed that dynamical systems were a model for intelligence. The descendant of this approach was coined as artificial neural networks.

This dynamical systems approach was later understood as being similar to an induction based thought process. Deep Learning leads to what can be characterized as Artificial Intuition.

Interesting to realize that the living things that lay the foundation of the biosphere are extremely robust as compared to the humans that are destroying the biosphere.

Seed can remain dry and dormant for ages only to reborn when provided the proper nutrients. In contrast, most animals require a continual living vessel to reconstruct itself from its DNA.

Evolution appears to constantly perform tradeoffs between robust organisms and organisms that are adaptable. Co-evolution makes possible the development of complex species as a consequence of robust organisms.

We exist as a consequence of the multitude of less complex individuals that make up our biosphere. We are in fact symbionts that are in constant cooperation with our microbiome. Absent our individual ecologies leads to death.

We are inseparable from our microbiome, we are inseparable from our societies, and we are inseparable from our biosphere. The biggest lie we are told is that as individuals, we are independent of our world.

All Biological life on earth is possible because of a discrete digital mechanism of preservation and replication.

The mechanism of signaling between the superorganism we know of as bacteria and its ongoing war against viruses is through a digital mechanism.

The source of innovation in biology is in this milieu of microbiome and viromes that are ubiquitous in every complex multicellular organism on earth. Humans are walking ecologies and cannot survive stripped of these ecologies.

We can picture this as a cloud of digital interaction that surrounds all of us.

The cells of multicellular creatures however do not communicate in the same way as bacteria. The DNA of mammals are sequestered from daily activity so as to prevent wear and tear.

Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

Highlights:
⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval

⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
⚪️Flow increased cellular viability & reduced apoptosis & cell death

⚪️Human islets in hydrogels were highly functional during the 10 day in situ culture in our chips, while islet function was rapidly lost under static conditions
⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.

1/Just had an interview scheduled with @goddeketal, Dr Simon Goddek, the post-doctoral researcher at the Faculty of Mathematics and Statistics in the field of biotechnology, at an unnamed Dutch university. This researcher has been publicly pointing out that the paper that...

2/ the PCR test as the gold standard underlying global "lockdowns" was passed after maximum ONE day of peer review, as opposed to the average at that same journal of 172 days in 2019. Also that several authors have conflicts of interest. Unfortunately we were forced to cancel..

3/ because he was strongly advised by his university to maintain silence and not speak publicly -- to step back from this issue. I learned from a source that his university was heavily assailed by many complaints. Other scientists who have signed the review criticizing the PRC..

4/test, the "Retraction Request Letter", a critique that got worldwide attention, have also been bombarded with attacks, their relatives are being called at night, and their universities assailed. Some are at risk of losing jobs. Even former employers are being harassed. I..

5/ Note : scientists around the world are being silenced and harassed if they speak up in normal criticism of the scientific methods or conclusions used to advance the lockdown agenda and COVID testing. This is not post-enlightenment scientific discourse, this is how scientists

The calamoid palms 🌴 have over 500 species spread across the world, but their higher-level relationships were a bit of a mystery. Until now.

Out today in #MolecularPhylogeneticsAndEvolution:

A robust phylogenomic framework for the calamoid palms https://t.co/JiCbSUlheH

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First some background info, so that you know what we are talking about:

Calamoid palms look a bit like snakes 🐍 (don't they!?!), because their fruits are covered in overlapping scales. And with their often fierce spines, they are equally fearsome. 😱

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They are classified into 17 genera, 10 subtribes and 3 tribes. They have an amazing variety of growth forms, from stemless to climbing to tree habit. 🌱🌴

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But as I said, their relationships have been a bit of a mystery. Here's the varying relationships previous studies found over the last 20 years.

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We tackled this mystery with a phylogenomic approach: we sampled almost a thousand genes (a hundred times more than previous studies!) of 75 species representing all calamoid tribes, subtribes and genera.

The resulting data matrix is pretty massive...

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