Now, a more technical tweet thread to give updates on the science - which is moving fast. Again, I recommend following @arambaut, @firefoxx66, @EBIgoldman, @The_Soup_Dragon, @pathogenomenick and @jcbarret along with others to stay on the cutting edge of this

Most important has been the paper by the @CovidGenomicsUK consortium on the new variant, here: https://t.co/b7yFFPXmsE
(This is super-rapid pre-print on https://t.co/PHmxAcVUoB - other people will pick over this no doubt - but the openness of the data and quality of analysis from this group means this is super solid, and any updates on discussion likely to happen fast)
Two key take aways from this paper for me:
1. There is a big jump in number of changes - too big to be explainable with the natural progression over time. @arambaut and colleagues point out that similar big jumps have happened in immunocompromised patients treated via convalescent plasma + drugs
2. This means there are both a number of potential things that could have changed and that it might be that there is synergistic effects - one now needs to test out what things are different in the lab and then work through each one in turn if there is a difference.
The other complication to this is that the 69/70 deletion is present on this branch. This deletion is complex for a variety of reasons
1. Firstly it is recurrent. We have seen this globally in Lyon (but to stress - *just* this event not the whole strain) and in the Danish outbreak that ended up in Mink farms (again, *just* this change not the whole set).
It is unusual to have sequenced so many individuals where one has a slow(ish) moving mutation rate and recurrent mutation. This is what gives @EBIgoldman and colleagues some new headaches (should one collapse multiple observations of the same sequence in likelihood calcs?)
2. This site overlaps with primer sites for some widely used RT-PCR tests. To stress, nearly all RT-PCR tests use 3 (sometimes more!) sites to assess, so having one "drop out" as it is called is ok.
This sounds concerning at first glance but shouldn't be (this is why they do 3 sites!) and for sure the test site will be moved. However, it does mean we can see this in the RT-PCR testing itself.
Here is Tony Cox, @The_Soup_Dragon showing how this variant rose over time. Please note that early on the red line here is likely to be a mixture of viral versions which have this change, but then you can see it take off. https://t.co/BWCHYFR1qy
This means we've got the numbers for lineage displacement (not just growth), meaning scientists can be pretty confident that this version of the virus is growing.
The recurrent mutation of this virus is interesting, and this variant also shares a mutation with a South African strain that also came into the news for potential faster transmission - to stress, these are certainly different lineages.

More from Science

What are the classics of the "Science of Science" or "Meta Science"? If you were teaching a class on the subject, what would go in the syllabus?

Here's a (very disorganized and incomplete) handful of suggestions, which I may add to. Suggestions welcome, especially if you've dug into relevant literatures.

1. The already classic "Estimating the reproducibility of
psychological science" from the Open Science Collaboration of @BrianNosek et al.
https://t.co/yjGczLZ6Je

(Look at that abstract, wow!)


Many people had pointed out problems with standard statistical methods, going back decades (what are the best refs?). But this paper was a sledgehammer, making it impossible to ignore the question: what, if anything, were we actually learning from all those statistical studies?

2. Dean Keith Simonton's book "Creativity in Science: Chance, Logic, Genius, and Zeitgeist". If an essentially scientometric book could be described as a fun romp through science & creativity, this would be it

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A brief analysis and comparison of the CSS for Twitter's PWA vs Twitter's legacy desktop website. The difference is dramatic and I'll touch on some reasons why.

Legacy site *downloads* ~630 KB CSS per theme and writing direction.

6,769 rules
9,252 selectors
16.7k declarations
3,370 unique declarations
44 media queries
36 unique colors
50 unique background colors
46 unique font sizes
39 unique z-indices

https://t.co/qyl4Bt1i5x


PWA *incrementally generates* ~30 KB CSS that handles all themes and writing directions.

735 rules
740 selectors
757 declarations
730 unique declarations
0 media queries
11 unique colors
32 unique background colors
15 unique font sizes
7 unique z-indices

https://t.co/w7oNG5KUkJ


The legacy site's CSS is what happens when hundreds of people directly write CSS over many years. Specificity wars, redundancy, a house of cards that can't be fixed. The result is extremely inefficient and error-prone styling that punishes users and developers.

The PWA's CSS is generated on-demand by a JS framework that manages styles and outputs "atomic CSS". The framework can enforce strict constraints and perform optimisations, which is why the CSS is so much smaller and safer. Style conflicts and unbounded CSS growth are avoided.
महाभारत की कहानी कौन नहीं जानता।लेकिन क्या आपको पता है कि महाभारत के ज्यादातर पात्र किसी न किसी श्राप में फंसे थे।अगर ये श्राप न होते तो कदाचित महाभारत की कहानी कुछ और होती।हिन्दु पौराणिक ग्रंथों में विभिन्न श्रापों का वर्णन मिलता है व हर श्राप के पीछे कोई कहानी अवश्य होती है।


आइए आज जानते हैं महाभारत कथा में वर्णित कुछ श्रापों के बारे में।

1) राजा पाण्डु को ऋषि किन्दम का श्राप

एकबार महाराज पाण्डु शिकार खेलने वन गए।झाडियों के पीछे कुछ हिल रहा था। मृग है सोचकर राजा ने बाण चलाया जो जाकर ऋषि किन्दम और उनकी पत्नी को लगा।वे दोनो रति-क्रीड़ा में लिप्त थे।

जब राजा ने उन्हें देखा तो बहुत दुखी हुए कि ये मुझसे क्या पाप हो गया।बहुत क्षमा याचना के बाद भी किन्दम ऋषि ने पाण्डु को श्राप दे दिया कि जब भी वो किसी स्त्री को काम भावना से स्पर्श करेंगे उसी क्षण उनकी मृत्यु हो जाएगी।पश्चाताप करने, वे सिंहासन पे अन्धे राजा धृतराष्ट्र को बैठाकर...


..स्वयं अपनी रानियों कुंती व माद्री के साथ वन चले गए।पांडवों का जन्म भी कुंती को ऋषि दुर्वासा द्वारा दिए गए मंत्र से हुआ था जिसमे किसी भी देव का स्मरण कर उस देव से कुंती,पुत्र प्राप्त कर सकती थी।एक बार माद्री पे मोहित हो जब पांडु ने उसे स्पर्श किया,उसी क्षण पांडु की मृत्यु होगयी।


2) उर्वशी का अर्जुन को श्राप

महाभारत युद्ध से पहले जब अर्जुन दिव्यास्त्र प्राप्त करने स्वर्ग गए तो वहां उर्वशी नाम की अप्सरा उन पर मोहित हो गयी। अर्जुन ने जब उन्हें अपनी माता के समान बताया तो यह सुनकर उर्वशी क्रोधित हो गयी और अर्जुन को श्राप दे डाला कि तुम नपुंसक की भांति...