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Saved by @Alex1Powell

Now, a more technical tweet thread to give updates on the science - which is moving fast. Again, I recommend following @arambaut, @firefoxx66, @EBIgoldman, @The_Soup_Dragon, @pathogenomenick and @jcbarret along with others to stay on the cutting edge of this

 Most important has been the paper by the @CovidGenomicsUK consortium on the new variant, here: https://t.co/b7yFFPXmsE
(This is super-rapid pre-print on https://t.co/PHmxAcVUoB - other people will pick over this no doubt - but the openness of the data and quality of analysis from this group means this is super solid, and any updates on discussion likely to happen fast)
Two key take aways from this paper for me:
1. There is a big jump in number of changes - too big to be explainable with the natural progression over time. @arambaut and colleagues point out that similar big jumps have happened in immunocompromised patients treated via convalescent plasma + drugs
2. This means there are both a number of potential things that could have changed and that it might be that there is synergistic effects - one now needs to test out what things are different in the lab and then work through each one in turn if there is a difference.
The other complication to this is that the 69/70 deletion is present on this branch. This deletion is complex for a variety of reasons
1. Firstly it is recurrent. We have seen this globally in Lyon (but to stress - *just* this event not the whole strain) and in the Danish outbreak that ended up in Mink farms (again, *just* this change not the whole set).
It is unusual to have sequenced so many individuals where one has a slow(ish) moving mutation rate and recurrent mutation. This is what gives @EBIgoldman and colleagues some new headaches (should one collapse multiple observations of the same sequence in likelihood calcs?)
2. This site overlaps with primer sites for some widely used RT-PCR tests. To stress, nearly all RT-PCR tests use 3 (sometimes more!) sites to assess, so having one "drop out" as it is called is ok.
This sounds concerning at first glance but shouldn't be (this is why they do 3 sites!) and for sure the test site will be moved. However, it does mean we can see this in the RT-PCR testing itself.
Here is Tony Cox, @The_Soup_Dragon showing how this variant rose over time. Please note that early on the red line here is likely to be a mixture of viral versions which have this change, but then you can see it take off. https://t.co/BWCHYFR1qy
This means we've got the numbers for lineage displacement (not just growth), meaning scientists can be pretty confident that this version of the virus is growing.
The recurrent mutation of this virus is interesting, and this variant also shares a mutation with a South African strain that also came into the news for potential faster transmission - to stress, these are certainly different lineages.

More from Science

Santa Fe Institute
Santa Fe Institute
@sfiscience
"You don't see radio changing gradually and suddenly become radar. #Darwin's theory doesn't work for #technology, and we have to make a new observation."

- W Brian Arthur at SFI today

#evolution #innovation #invention


"Novel technologies are constructed from existing technologies. These offer themselves as components for the construction of further technologies."

- W Brian Arthur at SFI today

#evolution #innovation #invention #technology #engineering #design


Unlike the two-parent #inheritance typical to (but not ubiquitous among) #complex organisms, #technology inherits features from n parents - a "vast ancestral #network" more like horizontal gene transfer networks in #bacteria.

W Brian Arthur on sumulating #invention on a chip:


Does #Archaeology support the Theory of the #AdjacentPossible - that #innovation is combinatorial, persistent, cumulative?

In short, yes. SFI's Tim Kohler on the #Paleolithic data of #technology #evolution & the #prehistory of the infamous "hockeystick" curve:

😉 @SAPIENS_org


#Economist Roger Koppl of @SyracuseU presents a model for the #AdjacentPossible at SFI.

Output = "a combinatorial explosion" or #singularity, albeit one that arguably occurred millions of years ago, or in the distant future (since the model doesn't specify t = 0):
SCIENCE
Lea Kissner
Lea Kissner
@LeaKissner
Next up at #enigma2021, Sanghyun Hong will be speaking about "A SOUND MIND IN A VULNERABLE BODY: PRACTICAL HARDWARE ATTACKS ON DEEP LEARNING"

(Hint: speaker is on the

In recent years ML models have worked from research labs to production, which makes ML security important. Adversarial ML research studies how to mess with ML

For example by messing with the training data (c.f. Tay which became super-racist super-fast) or by foiling ML models by changing inputs in ways humans can't see.


Prior work considers ML models in a standalone, mathematical way
* looks at the robustness in an isolated manner
* doesn't look at the whole ecosystem and how the model is used -- ML models are running in real hardware with real software which has real vulns!


This talk focuses on hardware-level vulnerabilities. This is particularly interesting because these can break cryptographic guarantees (because those are outside of their threat models)
e.g. fault injection attacks, side-channel attacks
SCIENCE
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Asbj\xf8rn St\xf8ylen
Asbjørn Støylen
@strain_rate
1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.


The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.


2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.


3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.


4/ The stretching of the septum builds up an elastic tension in the septum, which is released as recoil, when tension declines in the lateral wall, showing a post systolic shortening in the septum which is due to elasticity.
SCIENCE
Carlos E. Perez
Carlos E. Perez
@IntuitMachine
In physics, energy is that which is causally invariant or symmetric with respect to time. Said differently, energy is never created or destroyed, it is conserved in the universe.

Now there is a question about information. Is information causally invariant? Does information remain the same with respect to time? To understand this, let's first understand what energy is, then attempt to understand what information is.

The strange thing about energy is that it is this universal currency that seems to be interchangeable between the different forces in nature (i.e. electromagnetic, strong, weak and gravity). It is that thing that makes change possible.

Now let's assume that the universe is computational in nature. That is, anything we see in nature is a consequence of computation. That is, there is computation underneath the physics that is driving the universe to change.

What does it mean then that information is conserved in this computational universe? Also, how is energy conservation related to information conservation?
SOCIETY , SCIENCE
Marina Amaral
Marina Amaral
@marinamaral2
And since today is International Day of Women and Girls in Science, let's highlight a few of them - just a few women among thousands of others who helped shape the world we live in today.

Thread.


Dorothy Hodgkin discovered the structure of insulin after 36 years of work.

"I was captured for life by chemistry and by crystals."


Sophia Jex-Blake fought for women's rights to study medicine. She was involved in founding two medical schools for women.

"It seemed discreditable to Great Britain that all her daughters who desired a University education should be driven abroad to seek it."


Alice Augusta Ball developed the "Ball Method", the most effective treatment for leprosy during the early 20th century. She was 23.


Ada Lovelace is regarded as the first to recognize the full potential of computers and as one of the first computer programmers.

“That brain of mine is something more than merely mortal; as time will show.”
SOCIETY , SCIENCE

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Aneesh Philomina Antony
Aneesh Philomina Anton...
@ProdigalTrader
If u are looking to enter a scrip just before the breakout
what would u look for?
How would u identify scrips just before breakout?

Here are a few pointers
Carefully understand the them and use at ur own discretion
(All comments r compiled from a question i posed)

1/23

Price is testing the same resistance repeatedly since long.
But now in recent times it's forming multiple candles near the same resistance with low volume.
Observe it and see for opposite move.
As soon as u get a positive candle, get in to it.

2/23

1. Volume buildup (vol > when resistance point created) along with, increase in OI, increase in delivery % on HTF
2. On LTF, price stalling around breakout area for at least 1-2hr.
3. No major events.

3/23

Stock reaching breakout LVL with HL-HH
Contraction of price and volume near it especially near 20 days ma.
If there is any breach of the latest HL it should be followed by a bullish candle with good volume.
Left side of the chart has a rally with a very steep slope of ma.

4/23

Number of wide range green bars with high volumes.
If stock is at its ATH then it adds more conviction bcz there wont b supply after that point

Consolidation below the resistance, volume of the candles & strong bullish candle closing at near highs just below the resistance

5/23
TRADING , ALL
\u2745\u1710\u170b\u1713\u170e
❅ᜐᜋᜓᜎ...
@uglyluhan
First thread of the year because I have time during MCO. As requested, a thread on the gods and spirits of Malay folk religion. Some are indigenous, some are of Indian origin, some have Islamic


Before I begin, it might be worth explaining the Malay conception of the spirit world. At its deepest level, Malay religious belief is animist. All living beings and even certain objects are said to have a soul. Natural phenomena are either controlled by or personified as spirits

Although these beings had to be respected, not all of them were powerful enough to be considered gods. Offerings would be made to the spirits that had greater influence on human life. Spells and incantations would invoke their


Two known examples of such elemental spirits that had god-like status are Raja Angin (king of the wind) and Mambang Tali Arus (spirit of river currents). There were undoubtedly many more which have been lost to time

Contact with ancient India brought the influence of Hinduism and Buddhism to SEA. What we now call Hinduism similarly developed in India out of native animism and the more formal Vedic tradition. This can be seen in the multitude of sacred animals and location-specific Hindu gods
RELIGION
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Anu Satheesh \U0001f1ee\U0001f1f3
Anu Satheesh 🇮🇳...
@AnuSatheesh5
Eri Katha Ramar Temple
Maduranthakam

Eri Katha Ramar temple is located at Maduranthakam near Chengalpattu of Tamil Nadu. Beautiful Kodanda Ramar of about 8ft holding Ma Sita's hand & with Lakshmana. This temple story is connected with Sri Ramanujar.
@LostTemple7


It was here Periya Nambigal performed Pancha Samskaaram to Ramanujar under Magizham tree.
Sri Ramanujar was on his way from Kanchipuram to meet Sri Periya Nambigal at Sri Rangam to become his disciple. Sri Periya Nambigal also started towards Kanchipuram to meet Ramanujar.


They both met here at Madurantakam.
Small Mandapam where Ramanujar undertook Pancha Samskaaram is seen in the temple. Separate sannidhi is for Periya Nambigal & Ramanujar & this is the only temple where Ramanujar is seen as a Grahastha (married person) and not in Sanyasa kolam.


Story says about an incident which occurred during British rule. The Madurantakam lake bund was about to breach, due to heavy rain & village will be flooded if it happened. Dt collector was Cl. Lionel Blaze who took efforts to protect the bund & asked for the piles of stones


in the temple to protect it. But it was meant for Janakavalli ( sita) Thayar sannidhi which faced shortage of fund. Lionel Blaze prayed Sri Ramar to save the bund and if so he will provide fund to construct.
That night he saw in the lightning, Sri Rama & Lakshmana walked along
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Simon DeDeo
Simon DeDeo
@SimonDeDeo
This is a pretty valiant attempt to defend the "Feminist Glaciology" article, which says conventional wisdom is wrong, and this is a solid piece of scholarship. I'll beg to differ, because I think Jeffery, here, is confusing scholarship with "saying things that seem right".


The article is, at heart, deeply weird, even essentialist. Here, for example, is the claim that proposing climate engineering is a "man" thing. Also a "man" thing: attempting to get distance from a topic, approaching it in a disinterested fashion.


Also a "man" thing—physical courage. (I guess, not quite: physical courage "co-constitutes" masculinist glaciology along with nationalism and colonialism.)


There's criticism of a New York Times article that talks about glaciology adventures, which makes a similar point.


At the heart of this chunk is the claim that glaciology excludes women because of a narrative of scientific objectivity and physical adventure. This is a strong claim! It's not enough to say, hey, sure, sounds good. Is it true?
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Jeannette Ng \u5433\u5fd7\u9e97
Jeannette Ng 吳志麗...
@jeannette_ng
So, you’re a writer and you’re worried about writing outside your immediate experiences and identities.

Here is the thread of practical advice for you.

EXAMINE YOUR MOTIVES. Why do you want to write this?

Are you trying to solve racism/sexism/colonialism with your work?

As writers we love stories about heroic writers whose work has changed the world. And as such we like to look to our own writing to solve societal problems.

And I understand this completely, not the least because I’ve felt the pull.

But if you’re looking to play saviour with your words, it is unlikely that you will do the marginalised people you are trying to save justice.

And I understand this very often comes from place of good intentions, but there is a reason that most of the moralising plays written by white abolitionists are deeply uncomfortable to read.

It is incredibly easy for works looking to play saviour to become patronising or traffic in simplistic stereotypes that ultimately hurt the people they are looking to rescue.
WRITING