
You want to know about Barockschloss Ludwigsburg? Too bad, I'm going to tell you some stuff about it, as it's my 'local'...
Ludwigsburg Residential Palace is often nicknamed the \u2018Versailles of Swabia\u2019! Take with our #DailyDrone a bird\u2019s-eye view of one of the largest Baroque palaces in Germany. pic.twitter.com/9nn8oY34HG
— DW Culture (@dw_culture) December 21, 2020



So, he was essentially a big fat party animal from the get-go.

It's not such a stretch to say that this was his plan all along...




More from News
A quick thread on the new variant, pulling together information from news sources, twitter, genomic databases, and word from well-placed peers.
The new variant in the UK consists of several mutations in the spike protein, including ΔH69/ΔV70 deletions & other receptor binding domain mutations such as N501Y.
The variant is described here in this pre-print from @GuptaR_lab.
https://t.co/ui2U1r1ANA
The ΔH69/ΔV70 variant continues to increase quite rapidly as a proportion of overall positives (roughly doubling in the last 2 to three days), and is apparently now the dominant strain in test positives in some regions.
Extensive efforts have gone into enhanced surveillance for the ΔH69/ΔV70 deletion with and without RBD mutations, and it is good that we are aware of this.
There is a need for calm and rational thinking, and more evidence is needed.
But the early data is certainly concerning
Cabinet has been summoned for call at lunchtime. Lots of concern about new data on virus in parts of England, feels like fast moving situation. https://t.co/308YsJEVGw
— Nick Eardley (@nickeardleybbc) December 19, 2020
The new variant in the UK consists of several mutations in the spike protein, including ΔH69/ΔV70 deletions & other receptor binding domain mutations such as N501Y.
The variant is described here in this pre-print from @GuptaR_lab.
https://t.co/ui2U1r1ANA

The ΔH69/ΔV70 variant continues to increase quite rapidly as a proportion of overall positives (roughly doubling in the last 2 to three days), and is apparently now the dominant strain in test positives in some regions.
Extensive efforts have gone into enhanced surveillance for the ΔH69/ΔV70 deletion with and without RBD mutations, and it is good that we are aware of this.
There is a need for calm and rational thinking, and more evidence is needed.
But the early data is certainly concerning
SkyNews reporting "a major leak containing a register w/the personal identifying details of 1.95 mil Communist Party members [in #China], mostly from Shanghai, there are also the details of 79,000 Communist Party branches, many of them inside companies”.
What appears to be so newsworthy about this particular leaked list is the presence of CCP branches in not only foreign-invested firms in #China, but also in firms entirely located overseas.
This is by no means new-- I wrote several years ago about #China's massive Party-building drive to construct new CCP branches in Shanghai's NGOs in @chinaquarterly (The Advance of the Party: Transformation or Takeover of Urban Grassroots Society?* https://t.co/I1XKmkPKty )...
As well as the CCP's attempts to "comprehensively cover" 全覆盖 Shanghai's private sector in "The New Life of the Party: Party-Building & Social Engineering in Greater Shanghai" in the #China Journal, but what's apparently of concern in the leaked list..
...is the number of new Communist Party branches & committees now in Chinese-invested companies abroad. This is unsurprisingly going on on a massive scale in countries housing #China's Belt and Road projects as part of the CCP's "going out" 走出去efforts...#OBOR #BRI #一带一路
What appears to be so newsworthy about this particular leaked list is the presence of CCP branches in not only foreign-invested firms in #China, but also in firms entirely located overseas.
This is by no means new-- I wrote several years ago about #China's massive Party-building drive to construct new CCP branches in Shanghai's NGOs in @chinaquarterly (The Advance of the Party: Transformation or Takeover of Urban Grassroots Society?* https://t.co/I1XKmkPKty )...
As well as the CCP's attempts to "comprehensively cover" 全覆盖 Shanghai's private sector in "The New Life of the Party: Party-Building & Social Engineering in Greater Shanghai" in the #China Journal, but what's apparently of concern in the leaked list..
...is the number of new Communist Party branches & committees now in Chinese-invested companies abroad. This is unsurprisingly going on on a massive scale in countries housing #China's Belt and Road projects as part of the CCP's "going out" 走出去efforts...#OBOR #BRI #一带一路
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
