I'm hesitating to read or listen to this for fear it oversimplifies. I worked for about a year @NYPDnews on this. We learned a LOT. Most of the $320 million I estimate was lost by New Yorkers on Cyber-enabled scams in 2019 began with voice calls to set the hook...
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A quick thread on the new variant, pulling together information from news sources, twitter, genomic databases, and word from well-placed peers.
The new variant in the UK consists of several mutations in the spike protein, including ΔH69/ΔV70 deletions & other receptor binding domain mutations such as N501Y.
The variant is described here in this pre-print from @GuptaR_lab.
https://t.co/ui2U1r1ANA
The ΔH69/ΔV70 variant continues to increase quite rapidly as a proportion of overall positives (roughly doubling in the last 2 to three days), and is apparently now the dominant strain in test positives in some regions.
Extensive efforts have gone into enhanced surveillance for the ΔH69/ΔV70 deletion with and without RBD mutations, and it is good that we are aware of this.
There is a need for calm and rational thinking, and more evidence is needed.
But the early data is certainly concerning
Cabinet has been summoned for call at lunchtime. Lots of concern about new data on virus in parts of England, feels like fast moving situation. https://t.co/308YsJEVGw
— Nick Eardley (@nickeardleybbc) December 19, 2020
The new variant in the UK consists of several mutations in the spike protein, including ΔH69/ΔV70 deletions & other receptor binding domain mutations such as N501Y.
The variant is described here in this pre-print from @GuptaR_lab.
https://t.co/ui2U1r1ANA
The ΔH69/ΔV70 variant continues to increase quite rapidly as a proportion of overall positives (roughly doubling in the last 2 to three days), and is apparently now the dominant strain in test positives in some regions.
Extensive efforts have gone into enhanced surveillance for the ΔH69/ΔV70 deletion with and without RBD mutations, and it is good that we are aware of this.
There is a need for calm and rational thinking, and more evidence is needed.
But the early data is certainly concerning
You want to know about Barockschloss Ludwigsburg? Too bad, I'm going to tell you some stuff about it, as it's my 'local'...
It all came about because Eberhard Ludwig, Duke of Württe.berg, decided in 1704 that he wanted a big old palace from which to be an absolutist Duke, and do absolutist things. So, picking an old hunting lodge, he started to extend it...
Thing is, though, to build a residential palace, you need a workforce. To gain a workforce, they needed somewhere to live. So, alongside the palace, he founded the town of Ludwigsburg, now adjacent to Stuttgart.
Ludwig resided at Ludwigsburg until 1733, when, childless, he kicked the bucket. Then Carl-Eugen, a relative, became Duke, and that's when things became lit.
See Carl Eugen had been raised in the court of Frederick the Great, and had been deprived of fun and female company - they were banned from the Prussian court.
So, he was essentially a big fat party animal from the get-go.
Ludwigsburg Residential Palace is often nicknamed the \u2018Versailles of Swabia\u2019! Take with our #DailyDrone a bird\u2019s-eye view of one of the largest Baroque palaces in Germany. pic.twitter.com/9nn8oY34HG
— DW Culture (@dw_culture) December 21, 2020
It all came about because Eberhard Ludwig, Duke of Württe.berg, decided in 1704 that he wanted a big old palace from which to be an absolutist Duke, and do absolutist things. So, picking an old hunting lodge, he started to extend it...
Thing is, though, to build a residential palace, you need a workforce. To gain a workforce, they needed somewhere to live. So, alongside the palace, he founded the town of Ludwigsburg, now adjacent to Stuttgart.
Ludwig resided at Ludwigsburg until 1733, when, childless, he kicked the bucket. Then Carl-Eugen, a relative, became Duke, and that's when things became lit.
See Carl Eugen had been raised in the court of Frederick the Great, and had been deprived of fun and female company - they were banned from the Prussian court.
So, he was essentially a big fat party animal from the get-go.
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1/x Fort Detrick History
Mr. Patrick, one of the chief scientists at the Army Biological Warfare Laboratories at Fort Detrick in Frederick, Md., held five classified US patents for the process of weaponizing anthrax.
2/x
Under Mr. Patrick’s direction, scientists at Fort Detrick developed a tularemia agent that, if disseminated by airplane, could cause casualties & sickness over 1000s mi². In a 10,000 mi² range, it had 90% casualty rate & 50% fatality rate
3/x His team explored Q fever, plague, & Venezuelan equine encephalitis, testing more than 20 anthrax strains to discern most lethal variety. Fort Detrick scientists used aerosol spray systems inside fountain pens, walking sticks, light bulbs, & even in 1953 Mercury exhaust pipes
4/x After retiring in 1986, Mr. Patrick remained one of the world’s foremost specialists on biological warfare & was a consultant to the CIA, FBI, & US military. He debriefed Soviet defector Ken Alibek, the deputy chief of the Soviet biowarfare program
https://t.co/sHqSaTSqtB
5/x Back in Time
In 1949 the Army created a small team of chemists at "Camp Detrick" called Special Operations Division. Its assignment was to find military uses for toxic bacteria. The coercive use of toxins was a new field, which fascinated Allen Dulles, later head of the CIA
Mr. Patrick, one of the chief scientists at the Army Biological Warfare Laboratories at Fort Detrick in Frederick, Md., held five classified US patents for the process of weaponizing anthrax.
2/x
Under Mr. Patrick’s direction, scientists at Fort Detrick developed a tularemia agent that, if disseminated by airplane, could cause casualties & sickness over 1000s mi². In a 10,000 mi² range, it had 90% casualty rate & 50% fatality rate
3/x His team explored Q fever, plague, & Venezuelan equine encephalitis, testing more than 20 anthrax strains to discern most lethal variety. Fort Detrick scientists used aerosol spray systems inside fountain pens, walking sticks, light bulbs, & even in 1953 Mercury exhaust pipes
4/x After retiring in 1986, Mr. Patrick remained one of the world’s foremost specialists on biological warfare & was a consultant to the CIA, FBI, & US military. He debriefed Soviet defector Ken Alibek, the deputy chief of the Soviet biowarfare program
https://t.co/sHqSaTSqtB
5/x Back in Time
In 1949 the Army created a small team of chemists at "Camp Detrick" called Special Operations Division. Its assignment was to find military uses for toxic bacteria. The coercive use of toxins was a new field, which fascinated Allen Dulles, later head of the CIA
I'm going to do two history threads on Ethiopia, one on its ancient history, one on its modern story (1800 to today). 🇪🇹
I'll begin with the ancient history ... and it goes way back. Because modern humans - and before that, the ancestors of humans - almost certainly originated in Ethiopia. 🇪🇹 (sub-thread):
The first likely historical reference to Ethiopia is ancient Egyptian records of trade expeditions to the "Land of Punt" in search of gold, ebony, ivory, incense, and wild animals, starting in c 2500 BC 🇪🇹
Ethiopians themselves believe that the Queen of Sheba, who visited Israel's King Solomon in the Bible (c 950 BC), came from Ethiopia (not Yemen, as others believe). Here she is meeting Solomon in a stain-glassed window in Addis Ababa's Holy Trinity Church. 🇪🇹
References to the Queen of Sheba are everywhere in Ethiopia. The national airline's frequent flier miles are even called "ShebaMiles". 🇪🇹
I'll begin with the ancient history ... and it goes way back. Because modern humans - and before that, the ancestors of humans - almost certainly originated in Ethiopia. 🇪🇹 (sub-thread):
The famous \u201cLucy\u201d, an early ancestor of modern humans (Australopithecus) that lived 3.2 million years ago, and was discovered in 1974 in Ethiopia, displayed in the national museum in Addis Ababa \U0001f1ea\U0001f1f9 pic.twitter.com/N3oWqk1SW2
— Patrick Chovanec (@prchovanec) November 9, 2018
The first likely historical reference to Ethiopia is ancient Egyptian records of trade expeditions to the "Land of Punt" in search of gold, ebony, ivory, incense, and wild animals, starting in c 2500 BC 🇪🇹
Ethiopians themselves believe that the Queen of Sheba, who visited Israel's King Solomon in the Bible (c 950 BC), came from Ethiopia (not Yemen, as others believe). Here she is meeting Solomon in a stain-glassed window in Addis Ababa's Holy Trinity Church. 🇪🇹
References to the Queen of Sheba are everywhere in Ethiopia. The national airline's frequent flier miles are even called "ShebaMiles". 🇪🇹