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20 Most Important Lesson of 2020
// A THREAD //
It was a fast and weird year.
The year of change.
My life changed a lot and I learned even more.
Here are the 20 most important lessons - which will shape the upcoming decade for me.
1. Systems Are Better Than Goals
In the past, I failed many of my goals.
This year I've realized that it could be caused by the fact that they were goals, not systems.
Thanks, @ScottAdamsSays for helping me realize this.
Short article on the topic: https://t.co/lyBqGBR0yM
2. Use Notion More
@NotionHQ is definitely the most useful tool I've discovered this year.
I use it for:
- Twitter
- Freelance CRM
- Content Creation
- Website project management
And for personal use, it's completely free.
3. Email Is Immortal
This year we saw on social sites:
- Shadow bans
- Normal bans
- Decreasing reach (e.g. during the presidential election)
That's why I believe building an independent audience e.g. email list is mandatory.
P.S. https://t.co/iuhQJIf80K
// A THREAD //
It was a fast and weird year.
The year of change.
My life changed a lot and I learned even more.
Here are the 20 most important lessons - which will shape the upcoming decade for me.
1. Systems Are Better Than Goals
In the past, I failed many of my goals.
This year I've realized that it could be caused by the fact that they were goals, not systems.
Thanks, @ScottAdamsSays for helping me realize this.
Short article on the topic: https://t.co/lyBqGBR0yM
2. Use Notion More
@NotionHQ is definitely the most useful tool I've discovered this year.
I use it for:
- Freelance CRM
- Content Creation
- Website project management
And for personal use, it's completely free.
3. Email Is Immortal
This year we saw on social sites:
- Shadow bans
- Normal bans
- Decreasing reach (e.g. during the presidential election)
That's why I believe building an independent audience e.g. email list is mandatory.
P.S. https://t.co/iuhQJIf80K
Reading this article, the story sounds pretty wild. But I spent a weird amount of time with Martin Shkreli, and I’m not surprised the journalist fell in love w him
A few years back my team built an app called Blab. It was like clubhouse before clubhouse.
When he first joined the app I had no idea who he was. I just saw that his live streams instantly had 3-4K viewers. More than anyone on our tiny platform.
I googled him and it came up: “Martin Shkreli, most hated man in America”
I assumed he was bad news
And he was... but also he wasn’t.
He was a douchebag, but he was in on the joke. He was a dick, but he was also very entertaining.
In the mornings he would live stream himself analyzing stocks or walking through drug discovery pathways.
In the afternoon he’d let people call in and debate him live on air. A CNN reporter tried to get him to go on TV, he refused, and said debate me here on Blab, no edits, no tv time limits.
At night he’d host late night convos - and eventually fall asleep on cam
The guy was a pain in the ass but man he drove traffic.
We had big celebs like Tony Robbins, the Jonas brothers etc... he outperformed them all.
At one point he was bringing in 100k users per month directly to his channel. And Bc he was so entertaining, they stuck.
A few years back my team built an app called Blab. It was like clubhouse before clubhouse.
Christie Smythe covered white-collar crime for Bloomberg News and lived "the perfect little Brooklyn life" with her husband. Then she threw it all away for one of her sources: infamous pharma bro Martin Shkreli. https://t.co/Xk0zXmYkgF
— ELLE Magazine (US) (@ELLEmagazine) December 20, 2020
When he first joined the app I had no idea who he was. I just saw that his live streams instantly had 3-4K viewers. More than anyone on our tiny platform.
I googled him and it came up: “Martin Shkreli, most hated man in America”
I assumed he was bad news
And he was... but also he wasn’t.
He was a douchebag, but he was in on the joke. He was a dick, but he was also very entertaining.
In the mornings he would live stream himself analyzing stocks or walking through drug discovery pathways.
In the afternoon he’d let people call in and debate him live on air. A CNN reporter tried to get him to go on TV, he refused, and said debate me here on Blab, no edits, no tv time limits.
At night he’d host late night convos - and eventually fall asleep on cam
The guy was a pain in the ass but man he drove traffic.
We had big celebs like Tony Robbins, the Jonas brothers etc... he outperformed them all.
At one point he was bringing in 100k users per month directly to his channel. And Bc he was so entertaining, they stuck.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs