How?
By detecting either CTC (circulating tumor cells) or ctDNA (circulating tumor DNA). In some studies, ctDNA has been shown to have 100x the concentration as CTC though.
Genomics Thread #6
Let's talk about liquid biopsies...
How?
By detecting either CTC (circulating tumor cells) or ctDNA (circulating tumor DNA). In some studies, ctDNA has been shown to have 100x the concentration as CTC though.
Well, the standard of care is tissue biopsies. Doctors lop off a piece of the potentially cancerous area (a chunk of your lung for lung cancer for instance) to verify if cancer exists.
However, tissue biopsies are inferior in a few ways...
1. For one, there are more complications. Lung biopsies had a 19% complication rate.
2. They are also expensive, costing nearly $15,000 for each one.
3. They leave a scar and require a surgery
4. It takes a while to get the results
5. Not a lot of tissue can be retrieved
The main players that already have an approved test are Guardant Health and Foundation Medicine (owned by Roche).
Invitae also bought ArcherDx recently to be competitive.
Currently, most of the testing is done for NSCLC (non-small cell lung cancer).
To be clear, liquid biopsies won't completely replace tissue biopsies yet. However, there will likely be a "liquid-first paradigm."
If positive, then no need for tissue.
That's not to say liquid biopsies aren't accurate. They are. It's just that very early stage cancer can have very low concentrations of ctDNA.
https://t.co/mpOhGNNLtp
I wouldn't be surprised to see A LOT of new developments in this space in the next few years.
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And here they are...
THE WINNERS OF THE 24 HOUR STARTUP CHALLENGE
Remember, this money is just fun. If you launched a product (or even attempted a launch) - you did something worth MUCH more than $1,000.
#24hrstartup
The winners ๐
#10
Lattes For Change - Skip a latte and save a life.
https://t.co/M75RAirZzs
@frantzfries built a platform where you can see how skipping your morning latte could do for the world.
A great product for a great cause.
Congrats Chris on winning $250!
#9
Instaland - Create amazing landing pages for your followers.
https://t.co/5KkveJTAsy
A team project! @bpmct and @BaileyPumfleet built a tool for social media influencers to create simple "swipe up" landing pages for followers.
Really impressive for 24 hours. Congrats!
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SayHenlo - Chat without distractions
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Built by @DaltonEdwards, it's a platform for combatting conversation overload. This product was also coded exclusively from an iPad ๐ฒ
Dalton is a beast. I'm so excited he placed in the top 10.
#7
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Built by @jesswallaceuk, the project is focused on highlighting the experience of developers and people learning to code.
I wish this existed when I learned to code! Congrats on $250!!
THE WINNERS OF THE 24 HOUR STARTUP CHALLENGE
Remember, this money is just fun. If you launched a product (or even attempted a launch) - you did something worth MUCH more than $1,000.
#24hrstartup
The winners ๐
#10
Lattes For Change - Skip a latte and save a life.
https://t.co/M75RAirZzs
@frantzfries built a platform where you can see how skipping your morning latte could do for the world.
A great product for a great cause.
Congrats Chris on winning $250!
#9
Instaland - Create amazing landing pages for your followers.
https://t.co/5KkveJTAsy
A team project! @bpmct and @BaileyPumfleet built a tool for social media influencers to create simple "swipe up" landing pages for followers.
Really impressive for 24 hours. Congrats!
#8
SayHenlo - Chat without distractions
https://t.co/og0B7gmkW6
Built by @DaltonEdwards, it's a platform for combatting conversation overload. This product was also coded exclusively from an iPad ๐ฒ
Dalton is a beast. I'm so excited he placed in the top 10.
#7
CoderStory - Learn to code from developers across the globe!
https://t.co/86Ay6nF4AY
Built by @jesswallaceuk, the project is focused on highlighting the experience of developers and people learning to code.
I wish this existed when I learned to code! Congrats on $250!!
๐ฟ๐ป๐๐ ๐๐๐๐๐ ๐๐ ๐ ๐บ๐๐๐ : ๐ซ๐๐๐๐๐ & ๐ฝ๐๐๐๐๐
Once upon a time there was a Raja named Uttฤnapฤda born of Svayambhuva Manu,1st man on earth.He had 2 beautiful wives - Suniti & Suruchi & two sons were born of them Dhruva & Uttama respectively.
#talesofkrishna https://t.co/E85MTPkF9W
Now Suniti was the daughter of a tribal chief while Suruchi was the daughter of a rich king. Hence Suruchi was always favored the most by Raja while Suniti was ignored. But while Suniti was gentle & kind hearted by nature Suruchi was venomous inside.
#KrishnaLeela
The story is of a time when ideally the eldest son of the king becomes the heir to the throne. Hence the sinhasan of the Raja belonged to Dhruva.This is why Suruchi who was the 2nd wife nourished poison in her heart for Dhruva as she knew her son will never get the throne.
One day when Dhruva was just 5 years old he went on to sit on his father's lap. Suruchi, the jealous queen, got enraged and shoved him away from Raja as she never wanted Raja to shower Dhruva with his fatherly affection.
Dhruva protested questioning his step mother "why can't i sit on my own father's lap?" A furious Suruchi berated him saying "only God can allow him that privilege. Go ask him"
Once upon a time there was a Raja named Uttฤnapฤda born of Svayambhuva Manu,1st man on earth.He had 2 beautiful wives - Suniti & Suruchi & two sons were born of them Dhruva & Uttama respectively.
#talesofkrishna https://t.co/E85MTPkF9W
Prabhu says i reside in the heart of my bhakt.
— Right Singh (@rightwingchora) December 21, 2020
Guess the event. pic.twitter.com/yFUmbfe5KL
Now Suniti was the daughter of a tribal chief while Suruchi was the daughter of a rich king. Hence Suruchi was always favored the most by Raja while Suniti was ignored. But while Suniti was gentle & kind hearted by nature Suruchi was venomous inside.
#KrishnaLeela
The story is of a time when ideally the eldest son of the king becomes the heir to the throne. Hence the sinhasan of the Raja belonged to Dhruva.This is why Suruchi who was the 2nd wife nourished poison in her heart for Dhruva as she knew her son will never get the throne.
One day when Dhruva was just 5 years old he went on to sit on his father's lap. Suruchi, the jealous queen, got enraged and shoved him away from Raja as she never wanted Raja to shower Dhruva with his fatherly affection.
Dhruva protested questioning his step mother "why can't i sit on my own father's lap?" A furious Suruchi berated him saying "only God can allow him that privilege. Go ask him"
