If your bed is against an outside wall, move it away from it.
Staying warm while sleeping: use lots of blankets/comforters. Don't wear lots of layers to bed, they can trap sweat and oil and you'll kick off the blankets then get cold. Wear a toque or "beanie".
If your bed is against an outside wall, move it away from it.
And for clothes, layer up. Sweatpants and sweatshirts/hoodies are going to be your new besties.
- if you don't have to go anywhere, don't.
- if you don't have a ❄️🏔️ marking on your tires, they aren't winter rated.
- expect to triple or quadruple your stopping distances.
- drive slowly, your reaction time and what the vehicle will do are no longer matched
- avoid hills. If you don't have winter tires, it doesn't matter if they're plowed or not.
- 4x4 doesn't mean SFA if you're not experienced with snow.
- be aware that other drivers are probably not going to be as careful as you.
- two pairs of socks, and boots if you have them.
- if you don't have boots, or if your boots aren't reasonably water resistant, wear 2 pair of socks & some plastic grocery bags. The grocery bags will help keep your feet warm and dry in your shoes.
- bring an empty back pack. Carry bags home can risk cold injuries, plus it will help keep your load reasonable.
- staying warm means you need a higher caloric intake. Take five on your diet and enjoy some carbs and protein. Eating hot food is key. Warm everything up, no cold pizza! All your favourite Soul Food, Mexican cuisines, and so on? COLD WEATHER GOLD for food.
-20C = -4°F
-40C = -40°F
If you have to be outside, time your self and take lots of breaks to warm up.

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Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
