It’s time for T+2 to go. (1/9)

#SuvenLife – Niche R&D play..very high risk and very high reward…key is right allocation…

Jazz Pharma was quoting around $0.5 in 2009, today its $150 and Mcap of $8.5 Bn on Nasdaq..almost 300x in 11 years. 80% of its total sales ($2.1 Bn) come from single drug Xyrem.

Axovant Lifescience, bought Alzheimer molecule from GSK, repackaged it and done phase-3 trials. Before starting the trials, the valuation was $2 Bn, just before announcing the data, it rose to $3 Bn. One of the leading broker put the target of $12 Bn if the trials succeeded..

but it failed in phase-3 trials. Current Mcap is $120 Mn…

This is R&D for New Chemical Entity (NCE)…very high risk and very high reward…

Brain-related illnesses, also known as CNS diseases, afflict more than 2 billion people worldwide. Diseases of the brain and mind range

from Alzheimer’s, dementia, epilepsy, migraine, multiple sclerosis, neuro infections, Parkinson’s, psychosis, schizophrenia and stroke to brain injuries and various mental disorders. The global market or CNS therapeutics is projected to reach $137.7 billion by 2025.

#SuvenLife has 1 lead molecule SUVN-G3031 in phase-2 trials which is similar to Xyrem but superior features, 3 molecules completed phase-1 trials and starting phase-2 trials and 11 molecules in pre-clinical trials. All are related to CNS which is growing and uncluttered market

A statement about Stephanie Hayden.

In January I became aware that Ms Hayden (who monitors this account despite being blocked) had made a series of defamatory allegations about myself and my wife.

The allegations were made on Twitter, via Hayden’s account, and were widely retweeted.

The allegations were that as a result of her making a police complaint, (1) the police were seeking to urgently speak to me.

Furthermore (2) that police has spoken to me on 26/12/20 and offered some kind of “robust” advice about my conduct on and off line.

Finally (3) that police attended my home address in November, where my wife mislead them as to my whereabouts.

Hayden commented about this at length on Twitter, said that both and I am my wife had lied, and that I had even given a false address in Hampshire.

I said at the time all the allegations were false.

The police “complaint” was nothing more than Hayden making yet another vexatious complaint to the police, as Hayden routinely does.

The police did not speak to me on 26/12/20, as alleged, or at all.

So, here's my contrarian take on Why Trunk-Based Development Is Great But Probably Won't Work For You. Buckle up, it's a long one.

From time to time I talk about, or boost someone else's discussion of, "classical" continuous integration/trunk-based development/push-to-master/whatever. I do this because I've personally worked like this and I genuinely think it's a marvelous way to write software.

I've also, at this point in my career, failed—a bunch of times!—to bring this technique into practical use on the teams and organizations I've worked with. As a result, while I still do it myself, I don't focus as much on encouraging it in others.

The technoculture that's presently in vogue is what I think of as async/individual—optimize for the individual, performance-manage the individual, decouple the individual from others so they can be their best, most productive, most heroic selves.

This is in contrast to what I think of as sync/team—a culture that leans into interdependence and collaboration. If you've never worked on a team that collaborates very closely every day for months or years on end (and likes it) you've likely not experienced a team like this.

The evils committed by Ravi Zacharias were enabled by a toxic organizational leadership that is evidenced by how these same leaders responded when confronted about the widespread and ongoing abuses being perpetrated by the namesake of the institution. 1/29

Please take time to read this piece by @DavideAFrench and the 26-page letter written by a first-hand witness. Here are just some of the excerpts: 2/29

"At one point, Ravi suggested to me that the Task Force “issue a statement that they [the Thompsons] are hooligans, they are scoundrels, they are thugs, they are serial extortioners.” If we didn’t do that, he told me, he would ask his attorney to do so on his behalf." 3/29

"...I distinctly recall Ravi & Sanj mocking the Thompsons’ marriage & scornfully predicting how soon Brad & Lori Anne would get divorced. “I predict their marriage won’t survive the year,” Ravi asserted with laughter. “A year?” replied Sanj. “I wouldn’t give it six months!” 4/29

"In 2017, in the early stages of his RICO against the Thompsons, Ravi would often invoke Kelly [his attorney], making statements such as “my attorney said we are going to crush them.”" 5/29