BC FINANCE
Saved by @SteveeRogerr

#JPM2021 @GenapSys My Highlights: I think it's fair to say I am more excited than most about this #NGS company, as I see them as an example of how to enter the market while keeping a small profile ($249M raised so far).

 They now are aiming at 2021 to ship two new chips: 50MM read chip and 144MM sensor chip (not sure what the difference is between read/sensor).
They show a slide of price per Gb with #Illumina products as a reference, and their products now lined up, I think, for the first time with price per Gb info. Lowest will be the 144MM chip at ~$27/Gb.
As their technology is closer to the #IonTorrent than to the cycle-by-cycle SBS-based sequencing methods, they should have microindel errors in their profile. These look much better, almost null, than the S5 data they show in comparison.
The next slide, also about error rates, either for each base as the run progresses or sliced in GC% windows, has a lot of info, but difficult to read. I think the summary is that the @Genapsys profile shows a bit of microindel error but otherwise comparable to 100bp ILMN data.
The error profile starts low, very low actually, and then it hikes up after cycle 50-100+. In the slide below, they've been naughty and put a textbox on top of their error blue line, trying to hide it: don't think we won't notice these tricks! 😉
They say they've placed or booked more than 110 instruments so far (does that count early access?). All this is based on a 10K GS111 Sequencer + 10K Sequencing Prep instrument. They show long term plans for a GENIUSPrep (high throughput sample prep), but also ...
... but also bigger chips (500MM / 1000MM chip), as well as an Integrated System (zoom in).
Details of the 50M Chip. They seem to have gone from 100bp to 150bp standard now, but raw accuracy still placed at 99.9% at position 125bp. This may be the actual 144M chip but with standard Poisson loading, rendering a bit over 50M reads, or 8Gb per run, which is impressive...
... with a $20K capital investment, comparing the 50M @Genapsys at 8Gb ($54/Gb) and the #Illumina #iSeq100 at 1.2Gb ($542/Gb), that's roughly 8x better yield for Genapsys, and 10x better price per Gb. It makes the #iSeq100 look rather underwhelming in comparison.
The slide about 2021 plans changes the naming from 144M chip to "G4-50M and G4-100M", so this could mean that the nomenclature changes to reads per run rather than the size of the chip. Maybe both based on the 144M chip, but with better loading giving the 50M->100M jump in reads?
No reference to paired-end reads, only indications that 150bp may not be the end of it, and they may be able to go longer than that. Good news about the G4-100M, as it seems they have scope of improvement in loading.
Bonus picture of a "Personalize Genomics!" lab, or lab-at-home.
@d2unroll unroll

More from Finance

10-K Diver
10-K Diver
@10kdiver
Get a cup of coffee.

Let's kickstart 2022!

To that end, here are 22 key concepts to help you appreciate and achieve Financial Independence.

Concept #1.

What is Financial Independence?

It's a state of *self-sufficiency*. It's when you have enough money, and enough income-producing assets, that you and your family can live comfortably for the rest of your lives -- WITHOUT needing a job.

Concept #2.

Financial Independence is not really about spending MONEY how we like -- although, to an extent, that becomes possible.

It's about being FREE to spend our TIME how we like.


Concept #3.

Financial Independence is not really about quitting our jobs and retiring from work -- although that's possible.

It's about being FREE to pursue *whatever* kind of work we find most fulfilling. Things we love to do. Things the world benefits from. Etc.


Concept #4.

For most of us, the path to Financial Independence consists of:

- Starting Early,
- Saving Diligently, and
- Investing Responsibly.

Here's an inspiring story of a janitor who amassed an $8M fortune by following this very playbook:
FINANCE
Brian Feroldi
Brian Feroldi
@BrianFeroldi
1/ My Mission: To Spread Financial Wellness (thread)

Here’s what "financial wellness" means to me

⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️

2/ Mindset

Humans are programmed to think short-term

Evolutionary, thinking short-term makes sense. It helps with survival.

Financial wellness is all about training yourself to develop a long-term mindset

Not easy -- it takes practice


3/ Mindset

If you join the right tribes, you can’t help but improve

My favs:
@AffordAnything
@ChooseFiFI
FinTwit
@MicroCapClub
@themotleyfoolFool
@visualizevalue

Twitter / Podcasts / Blogs / YouTube -- when used correctly -- are amazing


4/ Mindset

Educate yourself - constantly!

Especially about:

1⃣Money
2⃣Relationships
3⃣Health

These 3 categories have an outsized influence on all areas of your life

Books


5/ Career

In the beginning, focus on growing your income

Do more than what is expected

Become a lynchpin

Find a career that you ENJOY (<- important!) that also has high-income potential

Start a side hustle (<- important!)

Build your talent
FINANCE
Advertisement
Simon Lelieveldt
Simon Lelieveldt
@finhstamsterdam
The Dutch regulator and DNB as financial supervisor are a tough cookie to deal with. In essence they hyperregulate EU-rules into goldplated Dutch rules which go beyond what is prescribed in Europe.

All NL-customers at British banks may thus be kicked out on brexit.

Thread

/1

If we start with the capital requirements directive, it says attracting deposits is forbidden. In article 9.

https://t.co/RYl7SXligC


Now the translation of that rule into Dutch law is slightly expanded to not only prohibit attracting deposits, but to also prohibit, having those deposits under custody ('ter beschikking hebben').

That's not in EU law, but it is in our Dutch law.

https://t.co/PsbWfNY3PA


So if you wonder how this would work out for UK banks and Payment institutions servicing Dutch customers. Have a read at the technical explanation of DNB, the financial supervisor and their summarising table.

https://t.co/LL0fAnYkRJ

Passive servicing of Dutch is not allowed!


Any bank or PSP in the UK that continues to serve Dutch customers (as in retail customers, professional players are excepted) can thus be subject to fines and policing under Dutch law.

Meaning we not only have Accidental American issues in payments, but also Accidental Dutchies
FINANCE
0xRafi
0xRafi
@0xRafi
1/ A thread on $APY @apyfinance. I believe this could become a major DeFi bluechip, and I’ve been waiting since the 10th Feb for the price to settle before posting this! But it just won’t. So I’ll post it now, but please go slowly if you buy it. It just did a 5x in 2 days!

2/ So the APY platform is a yield farming aggregator that uses a single pool of liquidity and automatic rebalances the portfolio among different strategies to optimise risk adjusted yield revenues. It is basically like having an automated fund manager managing your portfolio.

3/ Today, if for example, you have funds in a yearn vault and you realise another vault launched with better returns, it can cost 100’s of dollars in ETH fees to switch between them. For anyone not investing huge amounts, this makes switching strategies completely unpractical.

4/On APY, with a single deposit, users funds will be spread across multiple yield farming strategies and automatically rebalance over time to optimise risk-adjusted returns. So users won’t need to keep track & switch between strategies (+pay for fees!) to optimise yield over time

5/ The genius step here is that the $APY algorithm will track not only the strategies % yields, but also risk scores taking into account financial, liquidity or smart contract risks, so funds will be re-allocated over time in order to maximise yield but also manage risk.
FINANCE
Prashant Shah
Prashant Shah
@Prashantshah267
Thread: Central Pivot Range (CPR)

CPR is another popular tool. Three lines are plotted on the chart when we plot CPR.

The three lines are: CPR, TC and BC.

Let’s understand the calculation.


You may recall that I explained the calculation of Pivot levels in an earlier thread. CPR stands for Central Pivot Range. It is always a center line of the three lines that gets plotted in the chart.

CPR is a Pivot price. Pivot is average of HLC as explained in the prev thread.


We also discussed about Mid-range of the session. Mid-range is average of High and low price of the session.

The mid-range of the bar is known as BC in the CPR calculation. BC stands for Bottom central pivot.


Pivot level captures the relationship of the closing price to the range of the session.

Pivot price above mid-price = bullish pivot
Pivot price below mid-price = bearish pivot


So, CPR line is Pivot and BC line is Mid-range.

What is the difference between both?
Mid-range is average of High and Low.

Pivot is average of High, Low and Close.
What will make the difference between the two?

Close.
FINANCE , LEARNING

You May Also Like

Yoel Roth
Yoel Roth
@yoyoel
We’ve recently seen research about so-called “bots” and misinformation on Twitter and wanted to share our perspective on why findings that might seem remarkable at first are likely inaccurate. We’re working on a more detailed explanation, but some comments for now.

We continue to be excited by the research opportunities that Twitter data provides. Our service is the largest source of real-time social media data, and we make this data available to the public for free through our public API. No other major service does this.

Many researchers, academics, and journalists use our public API — a set of tools for programmatically accessing information on Twitter. We make all public Twitter content available via our APIs. You can learn more about them here:

The basic issue with much of the research based on our public APIs is simple: The APIs don't provide insight into our defensive actions to protect Twitter from manipulation, including bots.

Because of this, API-based research can't distinguish between accounts we've already identified as bad (and hidden or removed) and real, authentic ones.
TECH
Gleb Sabirzyanov
Gleb Sabirzyanov
@zyumbik
Don't look at deadlines negatively! They are a useful tool to measure your performance + stimulate you to do more. You can learn a lot from a single deadline. Did you work too little or too much? Was the goal too ambitious or easy? Apply lessons to the future work. 😉 #MyMindset


I wish I had this... — don't excuse yourself. Forget about what you can't and focus on what you can.
Stop comparing yourself to others, come from the point of what you have, know and have: "I can... so I will do..!" #MyMindset


BTW this was an update of one of the previous tweets. And I'm continuing this thread today!


Do something for the long-term. Everything else is a distraction. 🛑 Nowadays I always check if the thing I'm doing aligns with my long-term plans. If not — that is probably not the best thing to do at the moment. #MyMindset


The only way to get more done is to have less to do. Eliminate your obligations, say "no" to things that are not important, stay minimal in what you do, focus. Being busy is not equal to getting things done. #MyMindset
MAKERS
Advertisement
sriram
sriram
@SriramKannan77
Swami Ramanujar:
Important personalities in Sri Ramanujas Life :
🌸ASURI KESHAVA SOMAYAJI-Father of Sri Ramanujar .Asuri keshava somayaji was a learned brahmana living in sriperumbudur.


🌸KANTHIMATHI-Mother of Sri Ramanuja. Kanthimathi was the sister of sri periya thirumalai nambi .
🌸SRI YAMUNACHARYA-Acharya of Sri Ramanuja.Also known as Alavandar.
🌸THIRUKOKOSHTIYUR NAMBI-Also known as Ghosti Purna.He instructed the Rahasya Traya to Sri Ramanujar.

He lived in thirukoshtiyur.
🌸THIRUKKACHI NAMBI-Kanchi purna was born in puvirunthavalli near kanchipuram and met the young ramanuja at an important time.He did the service of Lord Varadha.

🌸THIRUVARANGA PERUMAL ARAIYAR-Important acharya lived in srirangam and rendered the service of playing music for lord Sriranganatha.

🌸PERIYA THIRUMALAI NAMBI-He was the maternal uncle of Sri Ramanuja.He taught sri ramanuja about the epic of sri ramayana and other ithihaas and puranas.Served sri venkateswara at tirumala.
ALL
Naval
Naval
@naval
How to Get Rich (without getting lucky):

Seek wealth, not money or status. Wealth is having assets that earn while you sleep. Money is how we transfer time and wealth. Status is your place in the social hierarchy.

Understand that ethical wealth creation is possible. If you secretly despise wealth, it will elude you.

Ignore people playing status games. They gain status by attacking people playing wealth creation games.

You’re not going to get rich renting out your time. You must own equity - a piece of a business - to gain your financial freedom.
LIFE , STARTUPS , NAVAL1
ArmaniTalks \U0001f399\U0001f525
ArmaniTalks 🎙🔥...
@ArmaniTalks
Manipulation Sign:

If you are compromising too much, there is a chance that you are getting manipulated.

Why are you the one that's always compromising?

How come the other person always gets their way?

Be more curious.

If something seems off, stick up for yourself.

'Wait, you sure I am being manipulated?'

I have no clue, that is only something that you can decide for yourself.

'Dang is there anything I need to look out for?'

Plenty..

But let me give you a few things to look out for.

👇

I see manipulation as skillfully controlling someone's behavior for egotistical or unethical purposes.

'How come people don't leave when it's happening to them?'

Because most people have 0 clue that they are being manipulated.

1. Guilt Trip

You ever made a mistake around someone, only for them to hold it over your head?

The will always bring up the mistake when you 2 are not seeing eye to eye.

These people will use that mistake as leverage to get what they want from you in the future.

Look out.

2. The Rationalizer

This person will commit the worst acts & find a way to rationalize it.

Example: cheaters when they get caught.

They have every excuse in the book for why they did it.

Heck, they are so good at rationalizing, they will make it seem like your fault.
LIFE