Abstract: Definitive antiviral properties are evidenced for niacin, i.e., nicotinic acid (NA), as coronavirus disease 2019 (COVID-19) therapy for both health restoration and prevention, to the level that progression of COVID-19 pathology may follow as an intrinsic function of NA
supply. This detailed investigation proposes thorough disentanglement of how the downstream inflammatory propagation of ensuing severe acute respiratory virus 2 (SARS-CoV-2) infection can either be prohibited or reversed upstream out the body to expeditiously restore health with
well-tolerated dynamic supplementation of sufficient NA (i.e., ~1-3 grams per day). Culmination of this research leads to realization of the potentially ubiquitous therapeutic and preventive powers of NA against inflammatory disease, in general.
Despite continued intensive efforts to mitigate the spread and burden of coronavirus disease 2019 (COVID-19) in populations, implications for the future remain unclear. Encouraging nonetheless is the vast understanding of the disease gained as a result of the unprecedented level
of collective rigor dedicated by scientists across the globe. Synthesis of the recent advancements made from such accelerated investigation augurs particularly dynamically supplied, sufficient dosage of immediate-release nicotinic acid (NA) as a strikingly promising therapeutic
antiviral agent to overcome pending challenges.
Motivation for this original investigation into specifically NA supply as COVID-19 treatment was sparked by deduction of the possibility that the counterintuitive link so dramatically and consistently observed (see
@phil_w888's page) of (cigarette/tobacco-nicotine) smoking
against ensuing severe acute respiratory virus 2 (SARS-CoV-2) infection may be explained by the fact that nicotine is oxidized into NA during the combustion process (at a rate of ~60 mg/day for a pack-a-day smoker) [1].
1.
https://t.co/PEhONXdY8D
Further, elucidation following extensive review of the developing relevant literature points to an exclusive ability for sufficiently supplied NA (upon which the human species continues dynamically to be thoroughly deficient through diet)—through its unique, intricate,
endothermic biochemical processing—to induce a thermodynamic flush response that appears to be mechanistically capable of reversing/restoring health from, and/or protecting against an assortment of inflammatory-induced diseases of acute and prolonged nature, such as COVID-19.
In turn, this may also explain the consensus body of relevant literature evidencing potent therapeutic and/or protective properties for sufficient dosage of immediate-release NA across the disease spectrum, including but not limited to demonstrated successful application against:
cardio-metabolic/vascular conditions [2-13],
2.
https://t.co/8rxHM3n7a6
arrhythmia/thrombosis [14-17],
14.
https://t.co/Yd1l8ohXJe
hepatic as well as renal function [3,18],
3.
https://t.co/CZvGy26eBu
pulmonary/lung injury [19],
19.
https://t.co/JgmKGaKmHC
viral/infectious diseases including influenza [20-22]
20.
https://t.co/EqyqJKq1BJ
and retroviruses like HIV/AIDs [23-26]
23.
https://t.co/d58DAM88q1
as well as tuberculosis [27],
27.
https://t.co/Sfs55oUoiW
thyroid-related disease [32,33],
32.
https://t.co/zhl3noVrJN
arthritic conditions [34],
34.
https://t.co/SxrWjhJ2L1
neurodegeneration/dementia/aging [35-41],
35.
https://t.co/GzJAezdb8b
auto-immune disorders [37,42],
37.
https://t.co/eXaSocerEE
birth defects [43]
43.
https://t.co/JJZdQT4YVB
and pre- or post-natal induced impairment of immune and neurodevelopmental function [44,45],
44.
https://t.co/6OzCDPbwc6
mental health disorders [46-49],
46.
https://t.co/LpESkUHO6l
mast cell conditions [50,51],
50.
https://t.co/6BFTTMOTtO
genetic disorders [43,52,53],
43.
https://t.co/JJZdQSNo43
dermatitis/eczema/psoriasis [55-60],
55.
https://t.co/AJqsFhaMZf
