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Ryan McNamara 🧬
@Ryan_Mac_Phd 5 years, 5 months ago 364 views

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The J&J vaccine reportedly confers 85% protection after 1 month. Some suggest this could be improved with a booster. About that...

J&J vaccine uses a replication-incompetent adenovirus (Ad26) to deliver the SARS-2 Spike protein. Here's what a typical adenovirus looks like: (1/5)

This particular adenovirus, Ad26, was likely chosen as antibody prevalence against it is very low in humans. This allows for the presentation of the SARS-2 Spike protein without the neutralization of the vehicle (Ad26). (2/5) https://t.co/4VnZ5jIkfI

Adeno-based vaccines are not new. They can elicit great antibody responses against a custom antigen, like SARS-2 Spike. But they also can elicit an antibody response against the adenovirus itself (esp. true for previous HIV vaccine candidates). (3/5)
https://t.co/iGhIwo5dU6

So a booster of an Adeno-based vaccine might actually be partially neutralized by antibodies made against the original adenovirus. This makes the boosters tricky for them.
Thankfully, the Ad26.SARS.2 from J&J is very good using 1 dose! (4/5)

* Moderna/Pfizer vaccines use inert lipid nanoparticles to deliver mRNA encoding for SARS-2 Spike. Since antibodies are not produced against the lipid nanoparticles, a booster works really well! The same can be true for component and live-attenuated vaccines. (5/5)

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Anu Satheesh
@AnuSatheesh5

Puthucode Annapoorneshwari Temple,
Palakkad, Kerala 🚩
#keralatemples
अन्नपूर्णे सदापूर्णे शङ्करप्राणवल्लभे
ज्ञानवैराग्यसिद्ध्यर्थं भिक्षां देहि च पार्वति

Temple is also called Puthukode Bhaghavathy Kshetram
Parasurama did Prathishta of Devi here. Temple is one amoung 👇

108 Durga temples
Navarathri festival is celebrated in a grant manner here. Annadanam is done daily on these days. The Idichu pizhinja payasam/ Chathachatayam is the main nivedyam in Annapoorneswari temple during Navarathri.
In the mornings, Devi Mahatmyam and Sundarakandam are

recited here daily.
Sri Godavarma Raja gifted lots of rice fields for the maintenance of the temple.
Annapoorneshwari holds Shanku and Chakra in her hands. Puthucode Annapoorneswari Temple is managed by the Naduvil Madom Devaswom.
🙏🕉🙏

Jaya_Upadhyaya
@Jayalko1

MEENAKSHI AMMAN, MADURAI (TN)
#bharatmandir #navratri2021

A paadal Petra sthalam where Shiva took the form of Sundareswarar (the handsome one) and married Devi Parvati (Meenakshi).
Devi is also known by the name Angayarkanni (mother with the beautiful fish eyes).
@GunduHuDuGa

Devi Meenakshi emerged from yagna fire as a 3 year old girl when Pandyan King Malayadwaja and Kanchanamalai were praying for a child.
It is said that Devi was born with three breasts and there was a prophesy that her superfluous breast would melt away when she met her husband.

Devi ruled over Madurai and captured Indralok. She went on to capture Kailasha. When she saw Shiva, her 3rd breast disappeared and she realised that Shiva would be her consort.
The divine marriage was attended by all Devas and Sri Vishnu (as her brother) gave her hand to Shiva.

It is said that Indra found a swayambhu lingam at Kadamba Vanam. He placed it in Madurai where the kshetram stands. Here, Shiva is seen on the vehicle of Indra.
The Golden Lotus Tank is said to be the place where a golden lotus blossomed for the puja performed by Indra.

The Meenakshi Thirukalyanam festival is celebrated in the Chithirai month to mark the divine marriage of Meenakshi Amman. The festival includes a procession where Meenakshi and Sundareshwara travel in a chariot and Sri Vishnu gives away his sister in marriage to Shiva.

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Vibhu Vashisth
@VIBHU_Tweet

THE UNTOLD TALE OF THE LESSER KNOWN WARRIORS:JOGRAJ GURJAR & RAMPYARI GURJAR AND HOW DID THEY DEFEAT THE CRUELEST ISLAMIC INVADER, TIMUR LANG.

Timur Lang, was the founder of Timurid Empire. He was born in April 1336 CE, somewhere in central asia.

During his reign, he conquered Persia, Egypt, Central Asia and emerged as the most powerful and heinous ruler. He was a religious fanatic like the rest of the Islamic invaders who tried to invade India.

Timur Lang decided to invade India in 1398 as he heard about India's splendid wealth and had a desire to conquer India which his ancestor Genghis Khan couldn't do.

After Firoz Shah's demise in1388, Delhi Sultanate was in a state of political turmoil.During this time, Timur sent his grandson Pir Mohammad to attack Indian front. He invaded Multan&was able to defeat Iqbal Khan's brother but when he met with resistance,he asked help from Timur.

Iqbal Khan secured his hold on Delhi under Muhammad Tughluq after Firoz Shah died.
Timur provided the required back-up to his grandson with 100000 men approx. Timur sacked and plundered all the cities coming in his way &later in October 1398 reunited with his grandson.

Angela Jamison
@AnJamison

@45RapeKatieJohn @buzz\_chronicles @buzz\\\_chronicles @buzz_chronicles save as category @pdfmakerapp grab @pdfmakerapp grab this @readwiseio save @readwiseio save thread @threader compile summarize @Threadreaderapp unroll please @ttttreads unroll @unrollthread.com @SaveToBookmarks

Buzz Chronicles
@buzz_chronicles

@SaveToBookmarks Namaste! You can find it here. Original tweet by @AchuthArora: "@AJA_Cortes @buzz_chronicles @rattibha @SaveToBookmarks save as Workouts". Enjoy 👌

Hi! There you go! Original tweet by @SaveToBookmarks: "@AchuthArora @AJA_Cortes @buzz_chronicles @rattibha Cool!

Your tweet has been s...". Cheers! 👉

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Vibhu Vashisth
@VIBHU_Tweet

ANCIENT BHARAT WAS CALLED VISHWAGURU, AND IT REALLY DESERVED IT.

India had a well developed education system centuries before the westerners arrived and called us uncivilized. Education was always given a great importance in Indian civilisation since times immemorial.

Ancient India had the Gurukulas and Ashramas as the epicentres of the knowledge and enlightenment. Bigger Gurukulas served as the centres of higher education called universities. Besides these universities, temples also emerged as the major learning centres.

Studying the Holy Scriptures, character building, personality development, responsibilities towards self,family and society,discipline and preservation of the ancient culture and heritage were the key embodiments of education.

This kind of education system made ancient India, a centre of knowledge all over the world. Many foreign students came to India for education and India was called the 'Vishwaguru'.
Takshshila and Nalanda were the two prominent universities of ancient India.

But were these only Universities of ancient India?The answer is 'No'.Let's learn about these gems of our education system that flourished across ancient India & be proud.

NALANDA UNIVERSITY
This was the oldest university of ancient India.Situated in Nalanda distt. of Bihar...

Seth Abramson
@SethAbramson

(MAJOR NOTE) The reason Manafort took over Trump's campaign in just 3 weeks despite being hired as a mere delegate counter is that ROGER STONE initiated a whisper campaign against Corey Lewandowski. That campaign started...days after Manafort returned from meeting with WikiLeaks.

2/ Stone and Manafort are longtime business partners; we'd expect Manafort to tell Stone what Assange told him, and for him to expect Stone to then pressure the campaign not only to hire him but quickly elevate him.

And who was Stone in touch with at the campaign? Trump himself.

3/ I bet you Manafort's late March emails are very interesting and that some of them are to/from his longtime business associate Roger Stone. And I bet Roger Stone's late March phone calls are very interesting and that some of them are to/from his longtime friend Donald Trump.

4/ At the end of March 2016, Trump suddenly convenes a NatSec meeting. At that meeting he directs his NatSec team to change the RNC platform in July to benefit Putin. Who later takes credit for that change?

Paul Manafort's business associate, Kremlin agent Konstantin Kilimnick.

5/ Why did Donald Trump suddenly convene a NatSec meeting 3 days after he finally hired Manafort? Why did he issue a pro-Kremlin directive at that meeting that Manafort's camp would later take credit for? What did Manafort tell Trump in the days leading up to that NatSec meeting?

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Mike DiCenzo
@mikedicenzo

"How the Avengers would respond to the Capitol riot" (a thread)

CAPTAIN AMERICA - tells Falcon, "I fought Nazis once before. They're extremely dangerous." They then see the guy scaling the Capitol wall fall into the shrubs. Falcon: "You sure these are the same Nazis?"

IRON MAN - lands by the guy carrying the podium. Says, "Mind if I borrow this?" then tosses it to Hulk, who swings it like a bat at the mob. Guy: "Hey, that's MY podium!" Iron Man: "Actually it's the Speaker's. And technically, it's a lectern." Then punches him through a wall.

BLACK WIDOW - enters hotel room where Jack Dorsey is tied up. Rips duct tape off his mouth. Jack: "I'll do anything you want!" BW: "Disable POTUS's Twitter. NOW!" Jack fumbles with his phone. "Done. Anything else?" BW: "Yeah. Trim your beard for God's sake." *tosses him clippers*

HULK - grabs a selfie stick from one of the guys and beats him over the head with it. Deeming it too small, he grabs another guy's Confederate flag and takes out a whole swath of rioters. He then tosses the flag to Cap, who uses it as a javelin to impale a fleeing Ted Cruz.

HAWKEYE - hears Iron Man in his earpiece say, "Looks like Orange Julius is tweeting from another account." Hawkeye: "On it." He locks in on Trump through the White House window and fires an arrow, knocking the phone out of Trump's hands. Hawkeye: "Damn that felt good."

$\u0936\u094d\u0930\u0940\u092e\u093e\u0932\u0940 \u0939\u093f\u0924\u0947\u0936 \u0905\u0935\u0938\u094d\u0925\u0940$

श्रीमाली हितेश अवस्थी...
@HiteshAwasthi89

Sri Parasurameswara Swamy Mandir, Gudimallam, Andhrapradesh

Gudimallam is a small village located in Chittoor district. It is seven miles away from Tirupati. This small village came to significance,due to it's very beautiful Shiva Mandir with history of thousands of years. 1/n

The main importance of the mandir lies in the Linga which is housed in the Garbhagriha of the temple & considered as the only one of such type. It is the earliest Linga discovered so far and it has been assigned to the 3rd century BCE.(Satavahana period) 2/n

SK
@sk_diary1

Kolaru Pathigam-Thevaram hymn composed by ThiruGnana Sambandar- #Thread

In Tamil Kol means planets,Aru means cut- set of songs in Kolaru Pathigam addresses all Navagrahas& last 2 lines of every song with end a plea to Bhagwan Shiva to reduce/erase the ill effects of Navagrahas

கோளறு பதிகம் - This pathigam was sung by Thirugnana Sambandar at Thirumaraikadu Kshetram -Vedaranyam,Tamilnadu

Thirugnana Sambandar & Appar(Thirunavukkarasar) travelled together to various Shiva Alayam to spread shivam & bhakti among people.They both reached Thirumaraikadu.

Thirumaraikadu(Vedaranyam) -
Appar & Sambandar were asked to enter the temple through side entrance.The main door was locked by Vedas many years ago.Appar&Sambandar sang devotional hymns praising Shiva, after which the gates opened & closed.After which main door opened for all.

After darshan of Bhagwan Shiva at Thirumaraikkadu,Sambandar received a message to travel to Madurai.
During that time, Samanam was on the rise in the Pandya Kingdom.The Pandya King converted to Samanam.The Queen Mangaiyarkkarasi was a staunch Shiva devotee and was upset.

Kularchirai Nayanar ,Chief Minister of Pandya kingdom was in agony by the turn of events.Queen requested Kulachirai Nayanar to escort Thiru gnana Sambandar to Madurai.Kularchirai Nayanar met Thiru gnana Sambandar at Thirumaraikkadu & requested him to visit Madurai.