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THREAD

Breaking down the “efficacy” and safety of the #COVID19 vaccines if applied to the population

 https://t.co/q8sXpkVxjs
https://t.co/tYCGHKgzqW
https://t.co/mQicBLheTJ
Pfizer vaccine summary: https://t.co/u4h7jZWbW8
Moderna vaccine summary: https://t.co/tiBOzjq1Xj
AstraZeneca vaccine summary: https://t.co/tPMa4II0ZE
IMPORTANT NOTE:

Given that only ~1 in 5 #COVID19 cases require hospitalization, this means that only ~20% of the already minute levels of decreases provided by vaccines in the occurrence of #COVID19 would prevent #COVID19 leading to hospitalizations...

https://t.co/UD5pIQjIY2
^ Hence:

* Pfizer vaccine would lead to only ~0.03% less #COVID19 hospitalizations over 1 week

* Moderna vaccine would lead to only ~0.24% less #COVID19 hospitalizations over 2 months

* AstraZeneca vaccine would lead to only ~0.24% less #COVID19 hospitalizations over 6 weeks
^ Simultaneously:

* Pfizer vaccine would cause 1,443,042 serious adverse events over 1 week

* Moderna vaccine would cause 3,081,988 serious adverse events over 28 days

* AstraZeneca vaccine would lead to 54,600,009 serious adverse events over 6 weeks

https://t.co/9Ckp1Fy53h
^ Barring further follow-up and surveillance, we currently have no idea how much more presentation of serious adverse events (resulting in: death, substantial risk of being life-threatening, hospitalization, and/or disability/permanent damage) would occur beyond these follow-ups.
Meanwhile, along with providing rapid health restoration, sufficient niacin supply is mechanistically established to serve as ensured protection against the development of #COVID19

Further, niacin is a safe, natural vitamin; readily available; & would cost <1 cent a gram in bulk https://t.co/rAFMIHzUeA
We also have no idea of effectiveness beyond brief follow-ups

Beyond brief follow-up, they could very well even exasperate burden of disease outcome (i.e. #COVID19 hospitalizations) that they intend to & do initially—albeit meaninglessly—protect against!

https://t.co/ROir4ebMjB
Some more on this... https://t.co/Yz2ji8aPRG

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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
MAHARAANI TARARANI: THE QUEEN OF MARATHAS

Rani Tarabai was the brave daughter-in-law of Chhatrapati Shivaji and one of the greatest medieval Monarchs India ever had.
She was born in 1675 to one of the bravest commander-in-chiefs of Shivaji's Army named Hambir Rao Mohite.


Tarabai was just 8yrs old when she was married to Shivaji's younger son, Rajaram. Mughals and Marathas were constantly at war with each other. Shivaji was crowned the ruler of the Independent Maratha Swarajya in 1674 which was established by him.


However,the great leader died in 1680&the Maratha Samrajya went into a complete&total chaos.Marathas saw some very tough times ahead. In 1689,when Raigad Fort fell to the Mughal Army of over 15000,Shivaji's first wife Saibai and his elder son Sambhaji were captured&put to death.


Sambhaji's wife and son Shahu were taken prisoners to the Mughal court. During the same battle, Shivaji's second son Rajaram(Tarabai's husband) , who was the heir to the throne now, managed to escape using a disguise. He made his way to the Gingee Fort in Tamil Nadu.


Mughal General Zulfikar Khan, however, followed them to Gingee laying siege to the Gingee Fort. From 1690-1698,This was the longest siege by a Mughal Army of any Fort which stands testimony to the military and diplomatic credentials of Rani Tarabai.
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
🌺श्री गरुड़ पुराण - संक्षिप्त वर्णन🌺

हिन्दु धर्म के 18 पुराणों में से एक गरुड़ पुराण का हिन्दु धर्म में बड़ा महत्व है। गरुड़ पुराण में मृत्यु के बाद सद्गती की व्याख्या मिलती है। इस पुराण के अधिष्ठातृ देव भगवान विष्णु हैं, इसलिए ये वैष्णव पुराण है।


गरुड़ पुराण के अनुसार हमारे कर्मों का फल हमें हमारे जीवन-काल में तो मिलता ही है परंतु मृत्यु के बाद भी अच्छे बुरे कार्यों का उनके अनुसार फल मिलता है। इस कारण इस पुराण में निहित ज्ञान को प्राप्त करने के लिए घर के किसी सदस्य की मृत्यु के बाद का समय निर्धारित किया गया है...

..ताकि उस समय हम जीवन-मरण से जुड़े सभी सत्य जान सकें और मृत्यु के कारण बिछडने वाले सदस्य का दुख कम हो सके।
गरुड़ पुराण में विष्णु की भक्ति व अवतारों का विस्तार से उसी प्रकार वर्णन मिलता है जिस प्रकार भगवत पुराण में।आरम्भ में मनु से सृष्टि की उत्पत्ति,ध्रुव चरित्र की कथा मिलती है।


तदुपरांत सुर्य व चंद्र ग्रहों के मंत्र, शिव-पार्वती मंत्र,इन्द्र सम्बंधित मंत्र,सरस्वती मंत्र और नौ शक्तियों के बारे में विस्तार से बताया गया है।
इस पुराण में उन्नीस हज़ार श्लोक बताए जाते हैं और इसे दो भागों में कहा जाता है।
प्रथम भाग में विष्णुभक्ति और पूजा विधियों का उल्लेख है।

मृत्यु के उपरांत गरुड़ पुराण के श्रवण का प्रावधान है ।
पुराण के द्वितीय भाग में 'प्रेतकल्प' का विस्तार से वर्णन और नरकों में जीव के पड़ने का वृत्तांत मिलता है। मरने के बाद मनुष्य की क्या गति होती है, उसका किस प्रकार की योनियों में जन्म होता है, प्रेत योनि से मुक्ति के उपाय...
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Aditya Todmal
Aditya Todmal
@AdityaTodmal
MASTER THREAD on Short Strangles.

Curated the best tweets from the best traders who are exceptional at managing strangles.

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How to sell Strangles in weekly expiry as explained by boss himself. @Mitesh_Engr

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Beautiful explanation on positional option selling by @Mitesh_Engr
Sir on how to sell low premium strangles yourself without paying anyone. This is a free mini course in


1st Live example of managing a strangle by Mitesh Sir. @Mitesh_Engr

• Sold Strangles 20% cap used
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• Booked profitable leg and rolled up
• Kept rolling up profitable leg
• Booked loss in calls
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2nd example by @Mitesh_Engr Sir on converting a directional trade into strangles. Option Sellers can use this for consistent profit.

• Identified a reversal and sold puts

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Anshumani Ruddra
Anshumani Ruddra
@baboonzero
Mahabharat - the great war - 18 days of heroism, deceit, blood and intrigue - now as a mega Twitter thread.

I'll add the events from a few days of the war each day.

Caveats: lots of editorialization, creative liberties and interpretations.

There will also be a lot of asides - especially around war strategy and tactics, the characters and their motivations and non-canon storylines.

Over the years, I've read multiple versions, phenomenal translations and modern retellings. So be prepared for a potpourri.

There are different ways of looking at this war. Was it a family feud? Sure - but whose family? Shantanu's or Satyavati's? Was Vyas essentially telling us his family history? And then Kunti added a twist to this tale. Here's a helpful chart:


Satyavati's two sons from Shantanu both died without children. Vyas - her first son - fathered Dhritarashtra and Pandu (and Vidur).

Pandu never fathered any children. Kunti and Madari gave birth to six demi-gods (Karna and the five Pandavs).

So Satyavati Vs Kunti and Madari.

Or was this a fight between two massive neighbouring kingdoms - the Kurus and the Panchals? While many smaller kingdoms joined the battle, most of the Pandav army (more than half of their 7 divisions) came from the Panchals. King Drupad and his son Shikhandi led two divisions.
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Buzz Chronicles
Buzz Chronicles
@buzz_chronicles
@SaveToBookmarks Namaste! There you go! Original tweet by @buzz_chronicles: "@SaveToBookmarks Namaste! You can find it here. Original tweet by @AchuthArora: ...". Enjoy 👌

Hi! There you go! Original tweet by @SaveToBookmarks: "@buzz_chronicles @AchuthArora @OllieEmberson @rattibha No more missed tweet 😉!

...". See You soon! 👉
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Dr Catherine Pemble is #SocialDistancing
Dr Catherine Pemble is...
@CatherinePemble
Right, screw it. Here's a thread on *that* FBLive by Alex Cairnie about #Govanhill. Lets do a watch-through shall we? (Mind, I'm a resident of Govanhill, and a sociologist. I'm also 5'3, and a visibly queer woman so if half his claims are true I should be living in terror)

00:30: Welcomes viewers and uses points out that his videos are only getting attention b/c they're 'horrific'. Directs folk to his Youtube page. So already clout hunting.

1:08: "I've been warned to stay out of Govanhill. I'm a marked man" (proceeds to use a beanie as a disguise)

1:30 "Laughing and joking aside, here's somebodys front garden." Proceeds to show litter and claim its thrown from windows and this is 'common'. I know a handful of streets with litter issues like this, but its neither common nor unique to #govanhill and other deprived areas.

2:10 "Don't be under any illusion I'm only showing you the bad bits" - only shows you the bad bits.

3:45: He's had offers of help, but hes said no because hes not responsible for 'anybody elses safety' Good lord.

5:01: "Its not that bad. But its not all good either" -Correct

6:00: TW: child abuse - He starts claiming to have been contacted by a health professional and told about child abuse 'in the area'. Huge ethical issues here as the 'professional' who has 'been in the game a long time' is reporting to Facebook Dude and not authorities.
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Suchi Sharma
Suchi Sharma
@Suchi_sharma_
#THREAD
1.Meenakshi Amman Temple(472ft High)also called as Meenakshi Sundareswarar is a famous Hindu temple located on the southern bank of Vaigai River in temple city of Madurai, #TamilNadu.It is dedicated to Parvati(Meenakshi)& her consort Shiva(Sundareswarar). @LostTemple7


2.Madurai Meenakshi Sundareswarar temple was built by King Kulasekara Pandya (1190-1216 CE).This popular temple visits over 15000 visitors daily & around 25000 on #Friday !Friday sees the most number of devotees visit the temple with the number going as high as +25,000.


3.Meenakshi Temple also hosts an annual festival called Meenakshi Thirukalayanam that is held in April. A celestial wedding of the god and goddess marks the end of the festival. About 1 million devotees visit the temple during this festival.


4.the temple has been tagged as one of the seven wonders of India along with stunning Architecture.The temple is built using Dravidian South Indian style of architecture, and is one of the most impressive temple structures in South India.


5.The principle deity here is MEENAKSHI, a form of Goddess Parvati. The idol of the goddess is carved in emerald hued stone. The Meenakshi idol has 3 breasts as Meenakshi was born with three breasts and was blessed that the 3rd breast would vanish once meets right man of her life
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)

@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice


@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2


@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj


@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
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Patrick McKenzie
Patrick McKenzie
@patio11
A thread on HN about bad code in legacy projects both makes me think how little we've learned as a discipline over the years and, honestly, how little credit we give ourselves for some pretty major

Fun going down this list and thinking: "Hmm, plausible at a well-run modern software shop", "Hmm, possible, but requires implausible tradeoffs", "Literally disallowed by languages", and "If you were to attempt doing that our test suite wouldn't let you merge."

I think we as an industry celebrate (not quite the right word) failure too much and don't celebrate success nearly enough. There is no DailyWTF for competent execution, word of which generally stays pretty local to the source while incompetence passes into legend.

Alrighty let me try to thread the needle on being the change I want to see in the world while not giving away anything that will get me in trouble:

Ruby has wonderful developer ergonomics. Typed languages are easier for machines to guarantee the correctness of. We built a type checker for Ruby (and I believe it is slated for OSS release sometime).

c.f.
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Respectable Lawyer
Respectable Lawyer
@RespectableLaw
There's been a lot of talk about the missionary killed by the natives of North Sentinel Island. They're probably so aggressive because of this weirdo, Maurice Vidal Portman. So here's a big thread about this creep and some facts from my decade-long obsession with the island.


The Sentinelese are often described as “uncontacted,” but this not strictly true. They had a very significant contact in 1880 with Commander Portman.

Portman, the black sheep third son of some minor noble, was assigned by the English Royal Navy to administer and pacify the Andaman Islands, a job he pursued from 1880-1900 with the full measure of his own perversity.


Portman was erotically obsessed with the Andamanese, and he indulged his passion for photography by kidnapping members of various tribes and posing them in mock-Greek homoerotic compositions.


During his 20 years in a sexualized heart of darkness, Portman measured and cataloged every inch of his prisoner’s bodies, with an obsessive focus on genitals.
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