1/10 When examining Statins, it should be noted that they have been shown to damage Mitochondria. Article – https://t.co/NIJbj3mULI. Mitochondrial damage can account for all of the relevant adverse effects of Statins – muscle weakness and damage, loss of memory/cognitive function

2/10 Diabetes, depletion of glutathione, etc. An interesting feature of mitochondrial injury is that a threshold of damage must be reached before a disease state results (as described in this article –

3/10 So, if your study period isn’t long enough, Statins truly will have the same number of adverse effects as sugar pills because in a short period of time, the subjects have not crossed their tolerance threshold for mitochondrial damage and no disease state (or adverse events)

4/10 have manifested. It is only with prolonged exposure to mitochondrial damaging chemicals, like Statins, that adverse effects manifest.
If you don’t design your study of mitochondrial damaging drugs to take into account how mitochondria react to assaults –

5/10 with an initial adaptive response followed by a toxic response (as the Peroxynitrite cycle is induced), your results don’t actually say anything notable. If you design your study to take into account the tolerance threshold feature of mitochondria,