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1/ n As promised, a quick thread. Combination of my (non-PhD / layman's) dive into learning about Monoclonal Antibodies and how it's helped me uncover a few fun / interesting group of companies: $SDGR $ABCL $TWST $IPA (new QQQ uplist -formerly $IPATD) and most recently $LGND
Ok - first, a *quick* history lesson - in the last ~3 months, I have been increasingly obsessed w/ learning about monoclonal antibodies. It started as a simple pattern recognition that a lot of the biotechs I was investing in were in this space - $HGEN $PRVB $MGNX $ONCT etc.
Not to mention, all of these new COVID therapeutics ( $LLY $REGN ) were antibody based - what the heck exactly are these things? I found myself watching basic videos - like this simple 3 minute cartoon summary...
.. to this podcast on the history of monoclonal antibodies, like this Nature podcast: https://t.co/iXcq56RR5l And a bunch of more academic / scientific white papers and articles that are far too dry to share here
Probably a good time to add that I barely made it past high school biology - my academic and professional background is all based around finance / math / SaaS - so as much as I'm interested in biotechnology, it's all self-taught and I needed to start with the basics
Ok - first, a *quick* history lesson - in the last ~3 months, I have been increasingly obsessed w/ learning about monoclonal antibodies. It started as a simple pattern recognition that a lot of the biotechs I was investing in were in this space - $HGEN $PRVB $MGNX $ONCT etc.
Not to mention, all of these new COVID therapeutics ( $LLY $REGN ) were antibody based - what the heck exactly are these things? I found myself watching basic videos - like this simple 3 minute cartoon summary...
.. to this podcast on the history of monoclonal antibodies, like this Nature podcast: https://t.co/iXcq56RR5l And a bunch of more academic / scientific white papers and articles that are far too dry to share here
Probably a good time to add that I barely made it past high school biology - my academic and professional background is all based around finance / math / SaaS - so as much as I'm interested in biotechnology, it's all self-taught and I needed to start with the basics
Let's look again at the 2005-2008 two parabolic advances in $gold. first, read yesterday's thread if you haven't:
Today i want to look what some major miners did - between the 2 parabolic gold advances: how did they act?
Getting more historic context in the minds, will allow us to navigate calmer the stormy waters ahead, and HOW we want to manage them.
(2)
my basic framework is we will see a parabolic metal top mid 2021, followed by another parabolic metal top early 2023.
Now what did some miners do in a same situation: the 2006-2008 timeframe.
Notice the $GDX was launched exactly a few weeks after the 2006 top 😉
(3)
example 1 of 4 is Barrick
gold lines = 2 gold parabolic tops.
Barrick didn't advance much first, and as such had only a 23% retrace before setting a floor.
Not something you would have wanted to trade.
Even with the 50% gold parabola retrace, the metal floor was $150 higher
example 2 of 4 is Hecla
while Hecla corrected 42%, the correction was very fast in time. The new metal floor made it quickly rise back after.
Something we could have hedged with SLV puts for example.
Silver retraced 38% and traded in tandem with $gold
How high can #gold run during this next intermediate cycle?
— Gold Ventures (@TheLastDegree) January 1, 2021
my current target stands at $2440 by May
targets are not exit points: the combination of a lot of signals/ratio's are. we adapt along the way
(1) https://t.co/QjuekzVzw1
Today i want to look what some major miners did - between the 2 parabolic gold advances: how did they act?
Getting more historic context in the minds, will allow us to navigate calmer the stormy waters ahead, and HOW we want to manage them.
(2)
my basic framework is we will see a parabolic metal top mid 2021, followed by another parabolic metal top early 2023.
Now what did some miners do in a same situation: the 2006-2008 timeframe.
Notice the $GDX was launched exactly a few weeks after the 2006 top 😉
(3)
example 1 of 4 is Barrick
gold lines = 2 gold parabolic tops.
Barrick didn't advance much first, and as such had only a 23% retrace before setting a floor.
Not something you would have wanted to trade.
Even with the 50% gold parabola retrace, the metal floor was $150 higher
example 2 of 4 is Hecla
while Hecla corrected 42%, the correction was very fast in time. The new metal floor made it quickly rise back after.
Something we could have hedged with SLV puts for example.
Silver retraced 38% and traded in tandem with $gold
I wasn’t planning to do the year-end collection of writings thread, but I would like to bury all the rather unpleasant notifications coming in from my critique of Stock, so...
I did not *write* much this year, but I was lucky to have a few things published anyway:
1. My essay “What *was* primitive accumulation?” — which has been online since 2017 — got its permanent published form in @EJPTheory vol. 19, issue 4:
The article argues against the recent revisionist accounts of primitive accumulation.
2. My highly critical review of Gareth Stedman Jones’s biography of Marx was published in Historical Materialism: https://t.co/tTh3FUaW1s An excerpt:
3. My engagement with @martinhaegglund’s This Life: Secular Faith and Spiritual Freedom appeared in @LAReviewofBooks, as part of a symposium on Hägglund’s book.
I did not *write* much this year, but I was lucky to have a few things published anyway:
1. My essay “What *was* primitive accumulation?” — which has been online since 2017 — got its permanent published form in @EJPTheory vol. 19, issue 4:
The article argues against the recent revisionist accounts of primitive accumulation.
2. My highly critical review of Gareth Stedman Jones’s biography of Marx was published in Historical Materialism: https://t.co/tTh3FUaW1s An excerpt:
3. My engagement with @martinhaegglund’s This Life: Secular Faith and Spiritual Freedom appeared in @LAReviewofBooks, as part of a symposium on Hägglund’s book.
12 Pivotal Moments that took the #NFT Industry exponential.
Not just money - we're talking Industry Progress & WTF Moments.
1/ Thread 👇
2/ #Decentraland goes public - Feb 20th
First impressions were, empty, lonely, buggy, crashes, not much to do, etc.
Now there's HQ's, Top DJ Events, 100+ Galleries and
December so far had over 5k weekly visitors.
I wrote a post-launch
3/ $WHALE Launches May 3rd - A social currency backed by $2M+ of #NFT assets by @WhaleShark_Pro & @whale_community.
People across all NFT projects & platforms were incentivized to work together.
A top social currency by market cap, volume AND community.
https://t.co/7RZ4QyNu8N
4/ @trevorjonesart Picasso's Bull sells for $55k on @niftygateway.
A record sale at the time for a single Art NFT. Many in the broader NFT space started to pay attention from here.
The drop totalled ~ $75k with a Silver /10 recently going for $19.5k! on 8th Dec, (from $750)
5/ Eth fees Sky rocket - Mid 2020
With Activity on ETH going berserk, ETH fees went from average $0.20 per transaction to now ~$5.4. More with NFTs.
This forced NFT projects, (especially gaming), to prioritize scaling/L2 while it was still 'ok' to trade Art as most are $300+
Not just money - we're talking Industry Progress & WTF Moments.
1/ Thread 👇
2/ #Decentraland goes public - Feb 20th
First impressions were, empty, lonely, buggy, crashes, not much to do, etc.
Now there's HQ's, Top DJ Events, 100+ Galleries and
December so far had over 5k weekly visitors.
I wrote a post-launch
3/ $WHALE Launches May 3rd - A social currency backed by $2M+ of #NFT assets by @WhaleShark_Pro & @whale_community.
People across all NFT projects & platforms were incentivized to work together.
A top social currency by market cap, volume AND community.
https://t.co/7RZ4QyNu8N
$WHALE ENTERS NFT & CRYPTO LAND
— WhaleShark.Pro (@WhaleShark_Pro) May 2, 2020
A revolutionary Social Currency that is backed by over 2,900 of the most valuable NFT assets in the World.
Read our Whitepaper: https://t.co/gfqdDoAv2g
Visit our Website: https://t.co/27cP5MNyM5
Join our Discord: https://t.co/lvLi5Vc5gR
4/ @trevorjonesart Picasso's Bull sells for $55k on @niftygateway.
A record sale at the time for a single Art NFT. Many in the broader NFT space started to pay attention from here.
The drop totalled ~ $75k with a Silver /10 recently going for $19.5k! on 8th Dec, (from $750)
5/ Eth fees Sky rocket - Mid 2020
With Activity on ETH going berserk, ETH fees went from average $0.20 per transaction to now ~$5.4. More with NFTs.
This forced NFT projects, (especially gaming), to prioritize scaling/L2 while it was still 'ok' to trade Art as most are $300+
I’d like to share a story about the benefits of investing in the private and public markets and how the private market mindset can help public equity investors.
2/A few years ago we invested in a private company called Meituan (3690 HK). Meituan is like doordash or Uber eats and we thought in China, with over 100 cities >1m pop, this would be a huge market. The other competitor was owned by Alibaba.
3/The company went public less than two years later at 70. We were ecstatic! Then the stock rapidly plunged to 40 based on renewed fears of competition with https://t.co/oVbw4yOOYV (Alibaba)
4/At the time we were locked up so there was nothing we could do. Today the stock is at almost 300 and $250B market cap. I fear what we might have done if not subjected to the lock up!
5/What’s the learning? In the private markets, the focus -FIRST- is TAM (size of market), then second everything else. And the stock price is static unless there is a new round. So you have time to develop your thesis.
2/A few years ago we invested in a private company called Meituan (3690 HK). Meituan is like doordash or Uber eats and we thought in China, with over 100 cities >1m pop, this would be a huge market. The other competitor was owned by Alibaba.
3/The company went public less than two years later at 70. We were ecstatic! Then the stock rapidly plunged to 40 based on renewed fears of competition with https://t.co/oVbw4yOOYV (Alibaba)
4/At the time we were locked up so there was nothing we could do. Today the stock is at almost 300 and $250B market cap. I fear what we might have done if not subjected to the lock up!
5/What’s the learning? In the private markets, the focus -FIRST- is TAM (size of market), then second everything else. And the stock price is static unless there is a new round. So you have time to develop your thesis.