BC VACCINE MANUFACTURING DIFFICULTIES
Saved by @khatvaanga

Vaccine supply chain management is a careful balancing act everywhere right now. Here’s a sampling of news to offer context:

US: https://t.co/d4C038NVrK

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 UK: https://t.co/LnGxuqJbkv

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Shortages in California in late March: https://t.co/ixaLo0oYPm

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UK supply disruptions late March: https://t.co/BStPj9rYGV

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Germany update late March : https://t.co/rlamkakowz

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Japan, which started this week after several delays - https://t.co/Em3wW0PTRm

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For context, India has multiple vaccines. It produces it all at home. One is entirely homegrown IP. The other we licensed because we have the demonstrated scale to make it at home.

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Multiple developed countries lack their own IP and manufacturing base. They are dependent on the vagaries of Pfizer supply choices made in another country: https://t.co/ZZxYmEgKT0

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The scale of Indian vaccine production is under appreciated:

https://t.co/u5n7hiZBSC

Table 4: of $155 billion in saved medical costs btwn 2001-20, SII’s vaccines alone contributed to $140 billion savings

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Here’s some additional data from WHO summarizing vaccine and generics suppliers (https://t.co/BafB9byVsp) . Page 5 and 6 are interesting.

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The current situation despite the existing manufacturing and development prowess is difficult - scale up production multiple times prior baseline, while simultaneously maintaining quality without any interruption. Distribute without any bottleneck anywhere.

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Most do not even have the luxury of having local supply, even if raw material is imported in some cases.

Ordering Pfizer in Sept 2020 hasn’t ensured EU reliable supplies as of April 2021. Pfizer is made in US, Belgium and Germany.

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The UK delayed second dose guidance to up to 12 weeks: https://t.co/QdXpj4Rtxq

… and exploring giving different vaccines for 2 doses: https://t.co/xRHiW4eiXK

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It’s beneficial to understand the challenges in a clear and unemotional manner.

To educate on the complexities of vaccine IP, let a famed immunologist speak. To understand how complex supply chain works, let someone who has run complex intl supply chain speak.

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The Indian population counts amongst it some of the most accomplished individuals in every aspect related to how this process works.

The population values education and deserves to learn the details and nuances of the problem and appreciate the nature of the challenge.

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A continuous stream of mind-numbing sensationalism does not serve the needs of the modern Indian state. We have amongst ourselves some of the worlds best medical professionals, technocrats, logistics and operations experts .

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People need to be able to clearly learn what they have to say about the various challenges associated with an effort on this scale and complexity. The effort needs to be benchmarked against the problems others are also facing.

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The role of the press here is to connect the expert knowledge directly to the public in clear understandable language. It cannot by itself monopolize the conversation. It leads to embarrassing gaffes like someone not knowing that Remdesivir is a chemical.

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The press isn’t expect to be domain experts and should pretend to be one. It has a job to connect the experts to the public and to let the public quietly learn and understand the details of the medical, technological and operational challenges itself.

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Vibhu Vashisth
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शमशान में जब महर्षि दधीचि के मांसपिंड का दाह संस्कार हो रहा था तो उनकी पत्नी अपने पति का वियोग सहन नहीं कर पायी और पास में ही स्थित विशाल पीपल वृक्ष के कोटर में अपने तीन वर्ष के बालक को रख के स्वयं चिता पे बैठ कर सती हो गयी ।इस प्रकार ऋषी दधीचि और उनकी पत्नी की मुक्ति हो गयी।


परन्तु पीपल के कोटर में रखा बालक भूख प्यास से तड़पने लगा। जब कुछ नहीं मिला तो वो कोटर में पड़े पीपल के गोदों (फल) को खाकर बड़ा होने लगा। कालान्तर में पीपल के फलों और पत्तों को खाकर बालक का जीवन किसी प्रकार सुरक्षित रहा।

एक दिन देवर्षि नारद वहां से गुजर रहे थे ।नारद ने पीपल के कोटर में बालक को देख कर उसका परिचय मांगा -
नारद बोले - बालक तुम कौन हो?
बालक - यही तो मैं भी जानना चहता हूँ ।
नारद - तुम्हारे जनक कौन हैं?
बालक - यही तो मैं भी जानना चाहता हूँ ।

तब नारद ने आँखें बन्द कर ध्यान लगाया ।


तत्पश्चात आश्चर्यचकित हो कर बालक को बताया कि 'हे बालक! तुम महान दानी महर्षि दधीचि के पुत्र हो । तुम्हारे पिता की अस्थियों का वज्रास्त्र बनाकर ही देवताओं ने असुरों पर विजय पायी थी।तुम्हारे पिता की मृत्यु मात्र 31 वर्ष की वय में ही हो गयी थी'।

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नारद - तुम्हारे पिता पर शनिदेव की महादशा थी।
बालक - मेरे उपर आयी विपत्ति का कारण क्या था?
नारद - शनिदेव की महादशा।
इतना बताकर देवर्षि नारद ने पीपल के पत्तों और गोदों को खाकर बड़े हुए उस बालक का नाम पिप्पलाद रखा और उसे दीक्षित किया।
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Brian Cates
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Trump is gonna let the Mueller investigation end all on it's own. It's obvious. All the hysteria of the past 2 weeks about his supposed impending firing of Mueller was a distraction. He was never going to fire Mueller and he's not going to


Mueller's officially end his investigation all on his own and he's gonna say he found no evidence of Trump campaign/Russian collusion during the 2016 election.

Democrats & DNC Media are going to LITERALLY have nothing coherent to say in response to that.

Mueller's team was 100% partisan.

That's why it's brilliant. NOBODY will be able to claim this team of partisan Democrats didn't go the EXTRA 20 MILES looking for ANY evidence they could find of Trump campaign/Russian collusion during the 2016 election

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They looked underneath every rock, behind every tree, into every bush.

And they found...NOTHING.

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Anu Satheesh \U0001f1ee\U0001f1f3
Anu Satheesh 🇮🇳...
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Chennimalai Murugan Kovil
#Erode
#TamilNaduTemples 🚩

Chennimalai Murugan Temple is located  near Perunthurai in Erode District. Murugan is worshipped here as Dandayudapani. Temple is situated on the banks of Noyyal river also called Kanchima Nadhi. Temple is situated in a hill


Sthala Puranam says that, there lived a Landlord who had many cows in his farm. One among them was a Black Cow, which didn't give milk. Land lord observed that evening time, when all the cows came back after grazing, this cow used to go to a particular spot and gave all  the milk


by itself. He decided to dig the spot where the cow gave its milk

On digging a beautiful Vigraham of Murugan was found, but lower portion was very rough. So he called a great sculptor to soften it. Everyone was shocked to see that on the first chisel the vigraham bleeded.


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Muruganukku Haro Hara
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