
⚡️⚡️ BIG THREAD! ⚡️⚡️ - GMO4DUMMIES CONCLUSIONS
On web-archive: https://t.co/RGxGjJm5Jc or direct: bit. ly/2LRL8Wt [no spaces course]
The initial GMO4D is on webarchive too: https://t.co/CFAhGWPahB !
Also direct: bit. ly/35RyHAE [no spaces]




In other words the presumed EXTINCTION mean> ADE/PP.




https://t.co/TCgNzY9rmp
\U0001f60a GMO4DUMMIES is life again! \U0001f60a
— Adrian Mario (@AdrianM_Ogy) January 18, 2021
Updated, saved on Wayback and zipped 4 download [fullversion]! Check with no spaces> bit. ly/35RyHAE or tinyurl. com/GMO4D333 pic.twitter.com/nfansGW4fj
More from Tech
A common misunderstanding about Agile and “Big Design Up Front”:
There’s nothing in the Agile Manifesto or Principles that states you should never have any idea what you’re trying to build.
You’re allowed to think about a desired outcome from the beginning.
It’s not Big Design Up Front if you do in-depth research to understand the user’s problem.
It’s not BDUF if you spend detailed time learning who needs this thing and why they need it.
It’s not BDUF if you help every team member know what success looks like.
Agile is about reducing risk.
It’s not Agile if you increase risk by starting your sprints with complete ignorance.
It’s not Agile if you don’t research.
Don’t make the mistake of shutting down critical understanding by labeling it Bg Design Up Front.
It would be a mistake to assume this research should only be done by designers and researchers.
Product management and developers also need to be out with the team, conducting the research.
Shared Understanding is the key objective
Big Design Up Front is a thing to avoid.
Defining all the functionality before coding is BDUF.
Drawing every screen and every pixel is BDUF.
Promising functionality (or delivery dates) to customers before development starts is BDUF.
These things shouldn’t happen in Agile.
There’s nothing in the Agile Manifesto or Principles that states you should never have any idea what you’re trying to build.
You’re allowed to think about a desired outcome from the beginning.
It’s not Big Design Up Front if you do in-depth research to understand the user’s problem.
It’s not BDUF if you spend detailed time learning who needs this thing and why they need it.
It’s not BDUF if you help every team member know what success looks like.
Agile is about reducing risk.
It’s not Agile if you increase risk by starting your sprints with complete ignorance.
It’s not Agile if you don’t research.
Don’t make the mistake of shutting down critical understanding by labeling it Bg Design Up Front.
It would be a mistake to assume this research should only be done by designers and researchers.
Product management and developers also need to be out with the team, conducting the research.
Shared Understanding is the key objective
I\u2019d recommend that the devs participate directly in the research.
— Jared Spool (@jmspool) November 18, 2018
If the devs go into the first sprint with a thorough understanding of the user\u2019s problems, they are far more likely to solve it well.
Big Design Up Front is a thing to avoid.
Defining all the functionality before coding is BDUF.
Drawing every screen and every pixel is BDUF.
Promising functionality (or delivery dates) to customers before development starts is BDUF.
These things shouldn’t happen in Agile.
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And here they are...
THE WINNERS OF THE 24 HOUR STARTUP CHALLENGE
Remember, this money is just fun. If you launched a product (or even attempted a launch) - you did something worth MUCH more than $1,000.
#24hrstartup
The winners 👇
#10
Lattes For Change - Skip a latte and save a life.
https://t.co/M75RAirZzs
@frantzfries built a platform where you can see how skipping your morning latte could do for the world.
A great product for a great cause.
Congrats Chris on winning $250!
#9
Instaland - Create amazing landing pages for your followers.
https://t.co/5KkveJTAsy
A team project! @bpmct and @BaileyPumfleet built a tool for social media influencers to create simple "swipe up" landing pages for followers.
Really impressive for 24 hours. Congrats!
#8
SayHenlo - Chat without distractions
https://t.co/og0B7gmkW6
Built by @DaltonEdwards, it's a platform for combatting conversation overload. This product was also coded exclusively from an iPad 😲
Dalton is a beast. I'm so excited he placed in the top 10.
#7
CoderStory - Learn to code from developers across the globe!
https://t.co/86Ay6nF4AY
Built by @jesswallaceuk, the project is focused on highlighting the experience of developers and people learning to code.
I wish this existed when I learned to code! Congrats on $250!!
THE WINNERS OF THE 24 HOUR STARTUP CHALLENGE
Remember, this money is just fun. If you launched a product (or even attempted a launch) - you did something worth MUCH more than $1,000.
#24hrstartup
The winners 👇
#10
Lattes For Change - Skip a latte and save a life.
https://t.co/M75RAirZzs
@frantzfries built a platform where you can see how skipping your morning latte could do for the world.
A great product for a great cause.
Congrats Chris on winning $250!

#9
Instaland - Create amazing landing pages for your followers.
https://t.co/5KkveJTAsy
A team project! @bpmct and @BaileyPumfleet built a tool for social media influencers to create simple "swipe up" landing pages for followers.
Really impressive for 24 hours. Congrats!

#8
SayHenlo - Chat without distractions
https://t.co/og0B7gmkW6
Built by @DaltonEdwards, it's a platform for combatting conversation overload. This product was also coded exclusively from an iPad 😲
Dalton is a beast. I'm so excited he placed in the top 10.

#7
CoderStory - Learn to code from developers across the globe!
https://t.co/86Ay6nF4AY
Built by @jesswallaceuk, the project is focused on highlighting the experience of developers and people learning to code.
I wish this existed when I learned to code! Congrats on $250!!

Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
