Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 https://t.co/O7dkEYpndg

In Academia, people aren’t always supported when they need it. I want to share what @WesternU did when my husband died right after the pandemic shutdown. It should be shared with other uni’s as a model for empathy and proactive care when someone is in crisis.
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#AcademicChatter

Important paper from Google on large batch optimization. They do impressively careful experiments measuring # iterations needed to achieve target validation error at various batch sizes. The main "surprise" is the lack of surprises. [thread]

https://t.co/7QIx5CFdfJ

The paper is a good example of lots of elements of good experimental design. They validate their metric by showing lots of variants give consistent results. They tune hyperparamters separately for each condition, check that optimum isn't at the endpoints, and measure sensitivity.

They have separate experiments where the hold fixed # iterations and # epochs, which (as they explain) measure very different things. They avoid confounds, such as batch norm's artificial dependence between batch size and regularization strength.

When the experiments are done carefully enough, the results are remarkably consistent between different datasets and architectures. Qualitatively, MNIST behaves just like ImageNet.

Importantly, they don't find any evidence for a "sharp/flat optima" effect whereby better optimization leads to worse final results. They have a good discussion of experimental artifacts/confounds in past papers where such effects were reported.

one of the things i like about Batman is that it's fundamentally about being orphaned, and being an orphan — how this guy stays tethered to the world in his own weird, abstract, extrajudicial way when he feels that his link to it has been violently severed

Batman does this by permanently recapitulating his own trauma: solving crimes for other people, protecting them. But that's actually just the beginning; he also recapitulates his own experience of orphanness by essentially raising several orphans

Dick is an orphan in the traditional sense: dead parents. Batman sees it happen. Jason, less so: missing dad, known mom who eventually dies. Tim, even less so: parents are around a while, and involved, before both dying. Carrie, even less than that: negligent parents.

Steph: evil father, who openly works against her. And then there's Damian, whose parents are both alive and yet both have identities that totally obliterate their role as his parents. He doesn't relate to them as a mother and father; he can't, and neither can they.

In all these different cases, Batman tries all these different ways of making orphanness for them not what it was for him: Either by trying to teach them the (arguably poor) coping skills early that he learned over a very long time, or by literally legally adopting them, etc.

It's another day to expose Peter Alabi @pastorpeealabi of @HoFChurchNG & @ChristTribe. More victims have reached out to us. Unknown to many, Peter Alabi is actually an unrepentant serial sexual abuser. We know that he's been lying that he has repented and that the stories...

... we have put out so far are only with reference to what happened years back. But we can also confirm that he continued to prey on more victims even after he left Ife in 2016. We also know that Peter Alabi made serious attempts to sleep with some ladies during the lockdown...

A victim, who was one of those Peter Alabi tried to sleep with during the Covid-19 lockdown has shared with us some of the chats between her and Peter Alabi, which were initiated by Peter Alabi. According to the victim, when Peter Alabi's intentions became obvious, she decided...

... to play along and act like she was in concert with him. This eventually made Peter Alabi to reveal his covert intentions to sleep with her. The chat began on Instagram in March 2020 and continued on WhatsApp till June 2020. We will be sharing screenshots of the Instagram...

... chats below. Later today, we will share the WhatsApp chats which are more revealing and expository. Please see the screenshots of the Instagram chats between Peter Alabi (peterayoalabi) and the victim below👇🏾 @oauchristians @HoFChurchNG @peterayoalabi @funlola_alabi