BC SCIENCE
Saved by @zmbnski

"You don't see radio changing gradually and suddenly become radar. #Darwin's theory doesn't work for #technology, and we have to make a new observation."

- W Brian Arthur at SFI today

#evolution #innovation #invention

 "Novel technologies are constructed from existing technologies. These offer themselves as components for the construction of further technologies."

- W Brian Arthur at SFI today

#evolution #innovation #invention #technology #engineering #design
Unlike the two-parent #inheritance typical to (but not ubiquitous among) #complex organisms, #technology inherits features from n parents - a "vast ancestral #network" more like horizontal gene transfer networks in #bacteria.

W Brian Arthur on sumulating #invention on a chip:
Does #Archaeology support the Theory of the #AdjacentPossible - that #innovation is combinatorial, persistent, cumulative?

In short, yes. SFI's Tim Kohler on the #Paleolithic data of #technology #evolution & the #prehistory of the infamous "hockeystick" curve:

😉 @SAPIENS_org
#Economist Roger Koppl of @SyracuseU presents a model for the #AdjacentPossible at SFI.

Output = "a combinatorial explosion" or #singularity, albeit one that arguably occurred millions of years ago, or in the distant future (since the model doesn't specify t = 0):
"We can't have universal models if organisms differ. But most of our models are universal. So how do our models need to differ for species-specific #search?"

- @toppofelin (@UniofOxford) reminds listeners at SFI today that we live in worlds, plural:
#umwelt #suchbild #affordance

More from Science

Sara Nayeem
Sara Nayeem
@SaraNayeem
Thread for folks looking for roles in biopharma VC. Nearly every week I speak to someone who wants to get into biopharma VC. One high-level theme: even for entry roles, you *generally* need to check the box “understands science” as well as the box “can do basic financial... 1/9
SCIENCE
Mercedes Pyatt \u2b50\ufe0f\u2b50\ufe0f\u2b50\ufe0f\U0001f438
Mercedes Pyatt ⭐️⭐️⭐️🐸...
@PyattMercedes
Q TALKS ABOUT FLAT EARTH...TRUTH IS COMING 💯
SCIENCE
Advertisement
KenOliveLab
KenOliveLab
@KenOliveLab
Extremely excited today to reveal the first of two great works (magnus opera?), just posted on bioarxiv, applying regulatory network analysis techniques to PDAC expression data to dissect the underlying biology of the disease. Tweetorial time! 1/

Eight years ago I launched an enduring collaboration with Andrea Califano @ColumbiaCancer to apply his regulatory network analysis techniques to #pancreaticcancer. So many amazing scientists have contributed to this work: @paslaise @hc_maurer @AlvaroCurielGa1 @ElyadaEla 2/

What is “regulatory network analysis”? At it's heart, it's a way of extracting more useful information from expression profiles. A fundamental flaw of differential gene expression (DGE) analysis is the assumption that each gene is independent. Biologist KNOW this is not true! 3/


DGE treats all ~25K detectable genes as SEPARATE variables, performs 25K T-tests, and then slaps on a multiple hypothesis correction to make the statisticians less dyspeptic. There is no consideration of the relationships between genes! 4/

Yet we KNOW genes are co-regulated in SETS by transcription factors and other REGULATORY FACTORS. Biologist: “p21 is a target of p53”. DGE: “Shhhh”. These relationships are completely ignored by expression analysis. THIS IS A TRAVESTY! 5/
SCIENCE
Yardley Yeadon
Yardley Yeadon
@MichaelYeadon3
In a number of Sunday papers:
Scientific advisers said it was “hard to see” when the restrictions would end as new variants continued to emerge, delivering a potentially devastating blow to the travel industry. The prime minister said that after progress with vaccinations...

...”what we don’t want to see is all that work undone by the arrival of a new variant that is vaccine-busting”.
The idea is planted in people’s mind that this virus is mutating in such a way as to evade prior immunity. This is completely unfounded, certainly as regards immunity..

...gained naturally, after repelling the virus (which well around 99.9% of the population do, fewer, obviously in the very elderly & already ill, more in those younger & well). It’s important to appreciate that upon infection, the human immune system cuts up an infectious...

...agent into short pieces. Each of these short pieces of protein are presented to other cells in the immune system, like an identity parade. Our cells have a truly astonishing range of abilities to recognise different protein structures, and there will be some which recognise...

...each of the pieces of the invader. The cells which recognise a piece are instructed to multiply selectively so that, after a few days to a couple of weeks, our bodies contain large numbers of virus piece specific cells. These have a range of functions. Some make antibodies...
SCIENCE
Daoyu
Daoyu
@Daoyu15
https://t.co/hXlo8qgkD0
Look like that they got a classical case of PCR Cross-Contamination.
They had 2 fabricated samples (SRX9714436 and SRX9714921) on the same PCR run. Alongside with Lung07. They did not perform metagenomic sequencing on the “feces” and they did not get


A positive oral or anal swab from anywhere in their sampling. Feces came from anus and if these were positive the anal swabs must also be positive. Clearly it got there after the NA have been extracted and were from the very low-level degraded RNA which were mutagenized from

The Taq. https://t.co/yKXCgiT29w to see SRX9714921 and SRX9714436.
Human+Mouse in the positive SRA, human in both of them. Seeing human+mouse in identical proportions across 3 different sequencers (PRJNA573298, A22, SEX9714436) are pretty straight indication that the originals

Were already contaminated with Human and mouse from the very beginning, and that this contamination is due to dishonesty in the sample handling process which prescribe a spiking of samples in ACE2-HEK293T/A549, VERO E6 and Human lung xenograft mouse.

The “lineages” they claimed to have found aren’t mutational lineages at all—all the mutations they see on these sequences were unique to that specific sequence, and are the result of RNA degradation and from the Taq polymerase errors accumulated from the nested PCR process
SCIENCE

You May Also Like

Tashny Sukumaran
Tashny Sukumaran
@tashny
Surendra Ananth @surendraananth, you violated my conditional consent. I assented to unprotected intimate relations with you on the STRICT condition that you tell me if you have relations with anyone else. You failed to do so, and I became ill as a direct consequence.

You refused to reveal your own STI results to me, but claimed to others they were negative and alleged I had multiple other partners, slut-shaming me. You gaslit me saying you had told me about your other partners.

You called up @justice_sisters and @SistersinIslam to tell them I was crazy, jilted. You rebuffed attempts to organise a community mediation so we could address matters. You said I was crazy for speaking to your boss and father in an attempt to keep other women safe.

You have a PATTERN OF BEHAVIOUR of misogyny, harassment and sheer disrespect for women. This was sent to a friend of mine who has never expressed interest in you and has a partner.


You think women are playthings, notches on the bedpost. You, @surendraananth, are no human rights advocate.
LAW
Noah Smith
Noah Smith
@Noahpinion
Met a Brazilian-American Lyft driver from San Diego who passionately attacked the racism of Republicans, then switched to passionately defending Bolsonaro.

If I were Thomas Friedman, I could tell you what this means.

Met a Haitian-American in a restaurant who said he'd always vote for Democrats because of the immigration issue, but that he has conservative beliefs too. "I don't want to pay for someone's abortion!", he declared.

Met a Latino Lyft driver from San Jose who said that while he was liberal, California was getting too liberal for him and he was considering moving to San Antonio.

Again, not being Tom Friedman, I am unable to offer any commentary on the political and policy implications of these conversations.

I guess my only thought is that political opinions are pretty complex and multidimensional, out there in the real world.

(end)
POLITICS
Advertisement
Jeet Heer
Jeet Heer
@HeerJeet
1. Now that Stan Lee is being eulogized far and wide, it's important to remember how marginal Stan Lee and his collaborators (Jack Kirby and Steve Ditko) were in the 1950s and 1960s.

2. Marvel Comics (before that Atlas) was just a cog in the machine of a bottom pulp publisher run by Martin Goodman, the husband of one of Lee's cousins. It was the lowest of the low in the publishing world.

3. Now Mario Puzo (not yet the author of the Godfather) shared offices with Stan Lee in the 1950s and 1960s. Puzo wrote for garrish men's adventure magazines and, like Lee, dreamed of writing a novel & breaking out. But Puzo looked down on Lee.

4. Flo Steinberg, 1960s secretary at Marvel: "They were always making jokes about us. They'd come in and giggle. mario Puzo would look in and would see us all working on his way to the office and say, 'Work faster, little elves. Christmas is coming.'"

5. When JFK was killed, the whole office of Magazine Management was stunned and quiet. Except Lee. He continued working. "He was still working on the comic books," Puzo said. "Like that was the most important thing in the world."
CULTURE
\U0001f1ee\U0001f1f3Sonal \U0001f1ee\U0001f1f3
🇮🇳Sonal 🇮🇳...
@Dharma_Vaarta
Bharat: Advancement of earth’s earliest civilization

Glorious Vedic Architecture and Temple

Architecture in India was an extremely rich form of expression and highly developed science, with a deep heritage of spirituality in it. #FreeHinduTemple


The centre of all architectural development was the temple and temple or Mandir was the earthly home of God, and like the launching pad for the devotee’s consciousness to soar toward the Divine and the spiritual world.


The murti or deity of the Divine would be placed in the temple sanctum, around which all temple activity would revolve.

Such buildings were often elaborately decorated with stone, wood, plaster, etc. and carved or cut to depict the stories from the Puranas or other sacred texts


Temples were always the centre of religious, social and educational activities, practically more so in
ancient times than today.

During a span of more than two thousand years, various dynasties were known for constructing glorious temples,


some of which include the Mauryan, Ashoka, Gupta, Satavahana, Chedi, Chandella, Chalukya, Solanki, Pallava, Shola, Hoysala, Vijayanagar, and others.

Many of these temples remain beautiful architectural wonders today.
ALL , HISTORY
Maker Weekly
Maker Weekly
@makerweekly
#24hrstartup recap and analysis

What a weekend celebrating makers looks like.

A thread

👇Read on

Let's start with a crazy view of what @ProductHunt looked like on Sunday

Download image and upload

A top 7 with:
https://t.co/6gBjO6jXtB @Booligoosh
https://t.co/fwfKbQha57 @stephsmithio
https://t.co/LsSRNV9Jrf @anthilemoon
https://t.co/Fts7T8Un5M @J_Tabansi
Spotify Ctrl @shahroozme
https://t.co/37EoJAXEeG @kossnocorp
https://t.co/fMawYGlnro

If you want some top picks, see @deadcoder0904's thread,

We were going to have a go at doing this, but he nailed it.

It also comes with voting links 🖐so go do your


Over the following days the 24hr startup crew had more than their fair share of launches

Lots of variety: web, bots, extensions and even native apps

eg. @jordibruin with
MAKERS