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#Arsenal re: rebuilding | I know we all want this club to be successful again. In that light, there is work to be done in terms of how we build-out the squad moving forward. But for me, that cannot be all about buying every single player (1/12) #AFC

 We are undoubtedly going to be linked to a lot of names from now and running through the summer...but what truly makes the most sense? Where in the team are - right now - the biggest questions? For me it's CM, CB, and long-term at CF. Most of the spine (2/12)
Yes Auba extended and we still have Laca, but both are on the wrong side of 30, and long-term, it's unlikely they'll be here and performing. The only question we don't have at CB is around Gabriel. The CM debate continues about a number of players & if they're good enough (3/12)
Arguments can easily be made for a CM purchase in the summer, as well as a CB depending on how things shake out with Mavropanos, Chambers, and Saliba's loan at Nice. What there should not be questions on, is our attacking options (4/12)
I am always adamant about the necessity in finding a balance between veteran pieces, a core of prime players, and a sprinkling of young talent that have unquestionable futures. You need all three to be a club that can sustain itself both financially and in terms of results (5/12)
The issue for me around the discussion of #Buendia is that, at 24, he's not far-off his prime years. He'll want a long term deal. But he plays in the same position(s) as both Smith-Rowe & Saka. Yes you always want to improve but you can still do that with academy products (6/12)
Many other big clubs, despite spending habits, will leave pathways clear for young players to develop and feature as first-choice options how they deserve. Should we not do the same with Saka, ESR, and Martinelli? (7/12)
Is not buying a player from the Championship, who has limited PL experience - despite, yes, being a good player - as risky as persisting with the kids? Who guarantees he will settle? Get on at the club? Improve as a player? Every transfer is a risk (8/12)
There is no bigger risk in allowing the aforementioned young players retain their first-choice status and grow with them as part of a long-term rebuild, while addressing issues in the spine in other areas (9/12)
You can be critical about how rated someone like Saka is, for example. But you do not reach the Golden Boy list if your talent is undeniable. It's debatable if he's in the top 5-10 in his bracket, but his potential is not. Do you risk blocking that? (10/12)
Is buying someone like Buendia so important that we actively run the risk of taking valuable time and experience away from a player who should be utterly key for this club in the short, medium, and long term? Potentially causing him to want out? For me, it's not (11/12)
If I had to choose between Buendia, and persisting with ESR and Saka at 10 & RW, I know what I'm choosing. Solve the need via the market across other areas of the pitch, while allowing our bright young attacking talents to flourish at the club. We can do both and improve (12/12)

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Rogier v Vlissingen
Rogier v Vlissingen
@vliscony
@jeffreyatucker In the end, it is all a natural consequence of a very human foible, namely that we all do everything we can to blame anybody or anything else for our problems, if we can get away with it. It's the reason why rulers start wars to squelch domestic dissent - macro and micro the same

The very notion of the germ theory of disease revolves around this and while it is good for selling medical interventions, treatments and pharmaceuticals, it is no good for either personal health, or public health in any way. We need to start looking at health on a holistic level

More of a systems approach to health would get us to see that the whole instinct to stamp out viruses, like the very counter-factual notion of "zero Covid," and other nonsense, are driven by this need to blame somebody or something else for our problems, so we can have our cake

and eat it too, i.e. we can pass the blame to others and go and kill them, be they bugs or other people (lockdowns???). The results are disastrous for health on both a personal and a public level, and we continue on a path of assured self-destruction. But times are changing, now.

Lifestyle Medicine @aclifemed provides the new paradigm, more of a systems approach to health, in which personal responsibility for our habits comes first, starting with nutrition. Immune systems become depressed by fatigue, stress, inner conflict, malnutrition and so on. Change
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jeevan patwa
jeevan patwa
@jeevanpatwa
#SuvenLife – Niche R&D play..very high risk and very high reward…key is right allocation…

Jazz Pharma was quoting around $0.5 in 2009, today its $150 and Mcap of $8.5 Bn on Nasdaq..almost 300x in 11 years. 80% of its total sales ($2.1 Bn) come from single drug Xyrem.

Axovant Lifescience, bought Alzheimer molecule from GSK, repackaged it and done phase-3 trials. Before starting the trials, the valuation was $2 Bn, just before announcing the data, it rose to $3 Bn. One of the leading broker put the target of $12 Bn if the trials succeeded..

but it failed in phase-3 trials. Current Mcap is $120 Mn…

This is R&D for New Chemical Entity (NCE)…very high risk and very high reward…

Brain-related illnesses, also known as CNS diseases, afflict more than 2 billion people worldwide. Diseases of the brain and mind range

from Alzheimer’s, dementia, epilepsy, migraine, multiple sclerosis, neuro infections, Parkinson’s, psychosis, schizophrenia and stroke to brain injuries and various mental disorders. The global market or CNS therapeutics is projected to reach $137.7 billion by 2025.

#SuvenLife has 1 lead molecule SUVN-G3031 in phase-2 trials which is similar to Xyrem but superior features, 3 molecules completed phase-1 trials and starting phase-2 trials and 11 molecules in pre-clinical trials. All are related to CNS which is growing and uncluttered market
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Roland Baker
Roland Baker
@RolandBakerIII
Moderna's mRNA-1273 & Pfizer's BNT162b2 consist of mRNA 3821 nucleotides long encoding *all* 1273 amino acids of the Spike including a 2 Proline-stabilized RBD. This is a plain English Description of the code:
https://t.co/w7koHyMJjL

The article mentions a “10 nucleotide linker” (GCAUAUGACU) in the poly-A tail. This is described in the patent link below (Modification of RNA, producing an increased transcript stability and translation

Here is a link to the full mRNA code if you wish to download it, blast it or make up a batch in your garage


An overview of the encoded spike


Initial mouse
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Infectious Diseases Fellows Network
Infectious Diseases Fe...
@ID_fellows
#IDTwitter #IDFellows
Introducing our new series: “IDFN top 10 articles every fellow should read”🔖

#1: SAB management
by @mmcclean1 @LeMiguelChavez
Reviewers @KaBourgi, @IgeGeorgeMD, @Courtcita, @MDdreamchaser

We know is subjective & expect feedback/future improvements 👇

1. Clinical management of Staphylococcus aureus bacteremia: a review.
https://t.co/9tBCtp9mlP
👉 A must read written by Holland et al. where they review the evidence of the management of SAB.

2. Impact of Infectious Disease Consultation on Quality of Care, Mortality, and Length of Stay in Staphylococcus aureus Bacteremia: Results From a Large Multicenter Cohort Study.
https://t.co/XujO68pCuH
👉ID consult associated with reduced inpatient mortality.

3. Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT): Scoring System to Guide Use of Echocardiography in the Management of Staphylococcus aureus Bacteremia
https://t.co/otcA1pxjAw
👉Predictive risk factors for infective endocarditis, and thus the need for TEE.

4. The Cefazolin Inoculum Effect Is Associated With Increased Mortality in Methicillin-Susceptible Staphylococcus aureus Bacteremia.
https://t.co/CQZiryVWZz
👉Presence of cefazolin inoculum effect in the infecting isolate was associated with an increase 30-day mortality.
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Angelo Carusone
Angelo Carusone
@GoAngelo
1/ All I keep thinking about in this moment are all the horrible things that Rush Limbaugh did and said. Just flashes of them.

Like how following Trayvon Martin's death, he tried to convince people it was okay to say "n word" now as long as you ended with an "a" (and said it).

2/ Or how, one of his "undeniable truths" was that "Feminism was established so as to allow unattractive women easier access to the mainstream of pop culture."

3/ Or how if a prominent woman would publicly defend another woman, he would refer to it as "solidarity of the vaginas."

4/ How he absolutely hated Michelle Obama...and used to refer to has as "moo-chelle." He really liked this because it both attacked her for mooching off system as he claimed and because it was his way of calling her a cow (he thought she was fat).

5/ He had this one song called "Barack the Magic Negro." The lyrics were even more racist than the name. And he played it all the time. He was still playing that song during his show a few months ago.
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श्रीमाली हितेश अवस्थी...
@HiteshAwasthi89
Bhu Varaha Swamy Temple

Bhu Varaha Swamy temple is a Hindu temple, located at Srimushnam, in the South Indian state of Tamil Nadu. Constructed in the Dravidian style of architecture...


the temple is dedicated to Varaha (Bhu Varaha Swamy), the boar-avatar of the god Vishnu and his consort Lakshmi as Ambujavalli Thayar.

The temple had contributions from Medieval Cholas of the 10th century with later expansions by Thanjavur Nayak king Achuthappa Nayak.


A granite wall surrounds the temple, enclosing all the shrines and the temple tanks. There is a seven-tieredrajagopuram, the temple’s gateway tower.

Six daily rituals and three yearly festivals are held at the temple, of which the Chariot festival....


celebrated during the Tamil month of Vaikasi (April–May), being the most prominent. The festival also symbolises Hindu-Muslim unity in the region – the flag of the chariot is provided by Muslims; they take offerings from the temple and present to Allah in the mosques.


Source & Pic credit : Anusri
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Anu Satheesh \U0001f1ee\U0001f1f3
Anu Satheesh 🇮🇳...
@AnuSatheesh5
Bhoga Lakshmi Narasimha Swamy Temple
#Devarayanadurga
#Karnatakatemples 🚩

Bhoga Yoga Narasimha Swamy Temple, Devarayanadurga is located near Tumkur of Karnataka. There are two temples are here for Narasimha Swamy, one is at the base of the hill which is Bhoga Narasimhar and 👇


the other on the top of  hill which is Yoga Narasimhar.

Bhoga Narasimha swamy Temple Prathista is said to be done by Maharshi Durvasa who did tapasya here. While doing tapasya Muni wished to bath in river Ganga and decided to travel to Ganga river bank,


At that time Ganga Devi appeared here and said she will remain here in the temple pond.

Yoga Narasimha swamy Prathista is believed to be done by Bhrama Deva who did tapasya here for many years.


Narasimhar appeared with Lakshmi Devi here to give darshan to Bhrama Deva here.

उग्रं वीरं महाविष्णुं ज्वलन्तं सर्वतोमुखम्।
नृसिंहं भीषणं भद्रं मृत्युमृत्युं नमाम्यहम् ॥

Om Shri Narasimha Murthaye Namah
🙏🕉🙏
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
राम-रावण युद्ध समाप्त हो चुका था। जगत को त्रास देने वाला रावण अपने कुटुम्ब सहित नष्ट हो चुका था।श्रीराम का राज्याभिषेक हुआ और अयोध्या नरेश श्री राम के नेतृत्व में चारों दिशाओं में शन्ति थी।
अंगद को विदा करते समय राम रो पड़े थे ।हनुमान को विदा करने की शक्ति तो राम में थी ही नहीं ।


माता सीता भी हनुमान को पुत्रवत मानती थी। अत: हनुमान अयोध्या में ही रह गए ।राम दिनभर दरबार में, शासन व्यवस्था में व्यस्त रहते थे। संध्या को जब शासकीय कार्यों में छूट मिलती तो गुरु और माताओं का कुशल-मंगल पूछ अपने कक्ष में जाते थे। परंतु हनुमान जी हमेशा उनके पीछे-पीछे ही रहते थे ।


उनकी उपस्थिति में ही सारा परिवार बहुत देर तक जी भर बातें करता ।फिर भरत को ध्यान आया कि भैया-भाभी को भी एकांत मिलना चाहिए ।उर्मिला को देख भी उनके मन में हूक उठती थी कि इस पतिव्रता को भी अपने पति का सानिध्य चाहिए ।

एक दिन भरत ने हनुमान जी से कहा,"हे पवनपुत्र! सीता भाभी को राम भैया के साथ एकांत में रहने का भी अधिकार प्राप्त है ।क्या आपको उनके माथे पर सिन्दूर नहीं दिखता?इसलिए संध्या पश्चात आप राम भैया को कृप्या अकेला छोड़ दिया करें "।
ये सुनकर हनुमान आश्चर्यचकित रह गए और सीता माता के पास गए ।


माता से हनुमान ने पूछा,"माता आप अपने माथे पर सिन्दूर क्यों लगाती हैं।" यह सुनकर सीता माता बोलीं,"स्त्री अपने माथे पर सिन्दूर लगाती है तो उसके पति की आयु में वृद्धि होती है और वह स्वस्थ रहते हैं "। फिर हनुमान जी प्रभु राम के पास गए ।
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V\u0936\u0941\u0926\u094d\u0927\u093f
Vशुद्धि...
@V_Shuddhi
The first ever world map was sketched thousands of years ago by Indian saint
“Ramanujacharya” who simply translated the following verse from Mahabharat and gave the world its real face

In Mahabharat,it is described how 'Maharishi Ved Vyasa' gave away his divine vision to Sanjay


Dhritarashtra's charioteer so that he could describe him the events of the upcoming war.

But, even before questions of war could begin, Dhritarashtra asked him to describe how the world looks like from space.

This is how he described the face of the world:

सुदर्शनं प्रवक्ष्यामि द्वीपं तु कुरुनन्दन। परिमण्डलो महाराज द्वीपोऽसौ चक्रसंस्थितः॥
यथा हि पुरुषः पश्येदादर्शे मुखमात्मनः। एवं सुदर्शनद्वीपो दृश्यते चन्द्रमण्डले॥ द्विरंशे पिप्पलस्तत्र द्विरंशे च शशो महान्।

—वेद व्यास, भीष्म पर्व, महाभारत


Meaning:-

हे कुरुनन्दन ! सुदर्शन नामक यह द्वीप चक्र की भाँति गोलाकार स्थित है, जैसे पुरुष दर्पण में अपना मुख देखता है, उसी प्रकार यह द्वीप चन्द्रमण्डल में दिखायी देता है। इसके दो अंशो मे पीपल और दो अंशो मे विशाल शश (खरगोश) दिखायी देता है।


Meaning: "Just like a man sees his face in the mirror, so does the Earth appears in the Universe. In the first part you see leaves of the Peepal Tree, and in the next part you see a Rabbit."

Based on this shloka, Saint Ramanujacharya sketched out the map, but the world laughed
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Kieran Snyder
Kieran Snyder
@KieranSnyder
1 There's a chasm between an NLP technology that works well in the research lab and something that works for applications that real people use. This was eye-opening when I started my career, and every time I talk to an NLP engineer at @textio, it continues to strike me even now.

2 Research conditions are theoretical and/or idealized. A huge problem for so-called NLP or AI startups with highly credentialed academic founders is that they bring limited knowledge of what it takes to build real products outside the lab.

3 A product is ultimately a thing that people pay for - not just cool technology or user experience. But I’m not even talking about knowledge gaps in go-to-market work. I'm talking purely technical gaps: how you go from science project to performant + delightful user experience.

4 Most commoditized NLP packages solve well-understood problems in standard ways that sacrifice either precision or performance. In a research lab, this is not usually a hard trade-off; in general, no one is using what you make, so performance is less important than precision.

5 In software, when you’re making something for real people to use, these tradeoffs are a big deal. Especially if you’re asking those people to pay for what you’ve made (can’t get away from that pesky GTM thinking). They expect quality, which includes precision AND performance.
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