Pep’s approach on Saturday bored a global audience to tears. Let’s look at:
Why he did it?
Why it worked?
And why we might have to get used to it?
A thread 1/
United didn’t create any big chances and only looked dangerous from set pieces 4/
‘When we struggle to score goals we have to be solid at the back, we had the chances’
‘We created 3 or 4 clear chances’ 6/
‘Put the ball in the goal. That is the solution’.
The double pivot is working, we can look at how City have performed when a Fernandinho/Rodri or Gundogan/Rodri double pivot has been deployed this season (PL/CL only) 8/
In the other 8 matches City have won 5, drawn 2 (Leeds & West Ham) and lost 1 (Spurs) conceding 5 goals 9/
So, with City now on a run of 6 consecutive clean sheets it was no surprise to see Pep stick with the shape throughout the 90 mins at Old Trafford and not go chasing the 3pts 11/
It may be frustrating for fans but Pep’s caution might be something we have to get used to 12/
More from For later read
Moderna's mRNA-1273 & Pfizer's BNT162b2 consist of mRNA 3821 nucleotides long encoding *all* 1273 amino acids of the Spike including a 2 Proline-stabilized RBD. This is a plain English Description of the code:
https://t.co/w7koHyMJjL
The article mentions a “10 nucleotide linker” (GCAUAUGACU) in the poly-A tail. This is described in the patent link below (Modification of RNA, producing an increased transcript stability and translation
Here is a link to the full mRNA code if you wish to download it, blast it or make up a batch in your garage
An overview of the encoded spike
Initial mouse
https://t.co/w7koHyMJjL
The article mentions a “10 nucleotide linker” (GCAUAUGACU) in the poly-A tail. This is described in the patent link below (Modification of RNA, producing an increased transcript stability and translation
Here is a link to the full mRNA code if you wish to download it, blast it or make up a batch in your garage
The mRNA sequences used for Moderna mRNA-1273 & Pfizer BNT162b2 mRNA vaccines for COVID-19 (Direct link in Word Format). WHO International Nonproprietary Name Program # 11889 "Messenger RNA encoding the full-length SARS-CoV-2 spike glycoprotein"https://t.co/zTb7B0Apic pic.twitter.com/8tZxAZWI5S
— Roland Baker (@RolandBakerIII) December 24, 2020
An overview of the encoded spike
Moderna's mRNA-1273 & Pfizer's BNT162b2 consist of mRNA 3821 nucleotides long encoding *all* 1273 amino acids of the Spike including a 2 Proline-stabilized RBD and this includes the NTD (blue in monomer, dark gray in trimer attached to antibodies). AA 64, 66, 187, 213, 214 red. pic.twitter.com/4MX1ByAsrR
— Roland Baker (@RolandBakerIII) December 19, 2020
Initial mouse
News: NIH-Moderna investigational COVID-19 vaccine shows promise in mouse studies https://t.co/7JYuUyZT45
— NIH (@NIH) August 5, 2020
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