One of the biggest knock-on effects of Liverpool's centre-back issues has been on the full-backs.

Klopp said explicitly in pre-season he had to rotate them, but now not wanting to further unsettle defence, he hasn't.

And now they both look absolutely knackered.

Another knock-on effect is, for example, in the decision to play 35 y/o Milner four times in 10 days (absolutely ridiculous decision typically, but needed because of fragility of the defence behind the midfield).
And, of course, losing Fabinho and Henderson for so long from midfield options not only removes what they provide in midfield, but knock-on effect is Wijnaldum (even Thiago latterly) being overplayed also.

It's a huge domino effect.
Then there's the lack of goal threat we have from attacking set pieces, which removes what was a quite impressive weapon for us previously.

It all makes it easier for opposition and harder for us.
Klopp so often mentions 'rhythm' and that's been almost impossible to have this season for so many reasons, going into every game with 4,5,more first-XI players missing. You then *have* to play the remaining 4,5 players and they become depleted.
Then those players on the periphery (Ox, Origi, etc) come into a disjointed side, lacking rhythm. It all goes on and on.
If you had Virgil and Gomez, Fabinho in midfield, you can then rotate players further ahead as the whole side is more stable. You've got half the XI out injured, and the other half fatigued and overly-relied upon. Perfect storm.
Eg, you'd be a lot more comfortable starting Neco or Kostas if you had Gomez/Matip, Virgil, Fabinho, Hendo in their correct positions. But now, you can't or you end up having an even more disjointed lineup. It's a nightmare.

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