One of the biggest knock-on effects of Liverpool's centre-back issues has been on the full-backs.
Klopp said explicitly in pre-season he had to rotate them, but now not wanting to further unsettle defence, he hasn't.
And now they both look absolutely knackered.
Another knock-on effect is, for example, in the decision to play 35 y/o Milner four times in 10 days (absolutely ridiculous decision typically, but needed because of fragility of the defence behind the midfield).
And, of course, losing Fabinho and Henderson for so long from midfield options not only removes what they provide in midfield, but knock-on effect is Wijnaldum (even Thiago latterly) being overplayed also.
It's a huge domino effect.
Then there's the lack of goal threat we have from attacking set pieces, which removes what was a quite impressive weapon for us previously.
It all makes it easier for opposition and harder for us.
Klopp so often mentions 'rhythm' and that's been almost impossible to have this season for so many reasons, going into every game with 4,5,more first-XI players missing. You then *have* to play the remaining 4,5 players and they become depleted.