I've been thinking about the debate of delayed vs. immediate 2nd dose for some time

Over past week, have become convinced that getting all doses out now is better

Its NOT a no-brainer

Reasonable people can (and do!!) disagree

So here's why my thinking evolved

Thread

Obviously, if you want to stick to the trials (reasonable position), then stay with standard interval

But soon, we'll be confronted with question -- do we give 2nd shot to some people or 1st shot to more people

Is there clinical trial evidence that 1 dose is helpful?

Yes

2/n

Yes

There is compelling data from Pfizer and Moderna trials that after about 10 d after 1 dose, you get 80-90% efficacy

https://t.co/38qlTYP77u

https://t.co/4V8SxM3tU5

So the BIG question is -- is that going to be durable beyond 21 to 28 days?

We don't know for sure

3/n

But while we may not be sure, it doesn't mean we have no idea

Here's one of our nation's most expert immunologists, @VirusesImmunity laying out her assessment of delayed vs immediate 2nd

What I take away from Dr. Iwasaki's thread and broader experience with vaccines is that it its unlikely that a short delay will harm protection

But we can't be sure

So why take this risk at all?

Why not just stay with the clinical trial?

Reasonable question

Here's why

5/9