https://t.co/10KPvahJ64
This issue is, appropriately, contentious. As a vaccinologist - & citizen & relative of people in at-risk groups - I fully support the UK decision to increase dose intervals of both our Ox/AZ product and the Pfizer product. I'd happily receive either with a >8w gap. Here's why 🧵
Short cut to JCVI rationale behind extending interval between doses of #covidvaccine (thanks @mgtmccartney)
— Dr Mark Porter (@drmarkporter) January 1, 2021
Note efficacy is "calculated" rather than proven at this stage.https://t.co/EbZWcJYkFt
https://t.co/10KPvahJ64
https://t.co/WrNVW5jRaW
@Bob_Wachter has written thoughtfully https://t.co/wZgvN937DV
@trishgreenhalgh @EricTopol @nataliexdean have all argued the other way from me - would welcome their thoughts on the above 🧵
U.S. is now considering idea of a single vaccination shot, delaying shot #2 until months later. Last wk, I thought that was a bad idea \u2013 the trials that found 95% efficacy were 2 shots; why add extra complexity & a new curveball. But facts on the ground demand a rethink. (1/7)
— Bob Wachter (@Bob_Wachter) December 31, 2020
More from Government
1.) HMX-1, which flies the VH-3D and VH-60N 'White Top' helicopters used to move... 1/X
Very noisy helicopters flying around Vice President\u2019s residence \u2014 what is going on? pic.twitter.com/XPs1A3px7m
— Michael Beschloss (@BeschlossDC) January 11, 2021
the President and VP around, those helos being called Marine One or Two when either is onboard, need to train. The urban landing zones, including WH and VP Residence, are not simple to get in and out of. So, crews need some currency training. They are not just tasked with... 2/X
moving POTUS and VP to get them around the region and to Andrews AFB for long-haul flights, they are essential to Continuity of Government operations. This means that if a threat were to emerge, they need to be ready to snatch POTUS and VP in minutes. This is partially... 3/X
why they have a full forward operating location at Naval Support Activity Anacostia, just 3 miles from the WH. As such, practice is important and considering the state of things, it is critical now more than in any recent memory. 4/X
2.) Considering what happened last week, including mobs of Trump supporters screaming in unison to hang the VP for doing what the constitution states, absolutely despicable in every way, security has been tightened just as it has been all over. Using the helicopters instead.. 5/X
So what should Peter Mandelson talk about at the recent Jewish Labour Movement conference – his worries that an independent process will hamper the party leader Keir Starmer?. #LabourLeaks #StarmerOut #LFI
Mandelson “was there in the 1980s and understands where the power bases of the right are, and how it should be exercised”. Who needs independent processes or oversight when you are in the driving seat?. #LabourLeaks #StarmerOut #LFI
Poale Zion trades as Jewish Labour Movement is a part of the Zionist Federation of the UK and organise within the World Zionist Organisation. You do NOT have to be Jewish or a member of the Labour Party to join. JLM contains CIA asset Ruth Smeeth. #LabourLeaks #StarmerOut #BICOM
Ruth Smeeth, one of the 60 plus anti-Corbyn resignations from the shadow cabinet, formerly held a post with the lobby group, Trevor Chinn's Britain Israel Communications and Research Centre (BICOM). #StarmerOut #BICOM #JLM https://t.co/H2a9vnsnRP
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@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o