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@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
I wish I had this... — don't excuse yourself. Forget about what you can't and focus on what you can.
Stop comparing yourself to others, come from the point of what you have, know and have: "I can... so I will do..!" #MyMindset
BTW this was an update of one of the previous tweets. And I'm continuing this thread today!
Focus only on positive things! These include what *you* have, know and can do. If you don't have, know or cannot do something either get it or ignore it. Don't think about it and don't use it as an excuse.
— Gleb Sabirzyanov (@zyumbik) October 17, 2018
I've been struggling to follow this principle for a long time. #MyMindset pic.twitter.com/SK5vtwHs3G
Do something for the long-term. Everything else is a distraction. 🛑 Nowadays I always check if the thing I'm doing aligns with my long-term plans. If not — that is probably not the best thing to do at the moment. #MyMindset
The only way to get more done is to have less to do. Eliminate your obligations, say "no" to things that are not important, stay minimal in what you do, focus. Being busy is not equal to getting things done. #MyMindset