
1. “Dr Tomas Ryan : Sociopath Or Psychopath : Or Both ?”
Answer = Both. Shortest Thread Ever. Only joking. Let’s jump in and try to see what makes Dr Tomas Ryan tick 🧵 1/21



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"It's correct to say that NPHET is an advisory group, but I don't consider it to be an expert group"
— TonightVMTV (@TonightVMTV) May 27, 2020
Prof @TJRyan_77 outlining why he believes NPHET is lacking experts. #TonightVMTV pic.twitter.com/kpasnv1pfj
"Tony Holohan is the frog who came into the water when it was already boiling."
https://t.co/70Sb367UBM
"Tony Holohan is the frog who came into the water when it was already boiling."@TJRyan_77 says we need to crush the second curve and prevent a third curve#TonightVMTV pic.twitter.com/k8aBoKQ3i0
— TonightVMTV (@TonightVMTV) October 6, 2020
https://t.co/fhCSpqa3LI
"The elimination is the best situation for the economy and the best situation for healthcare, the most challenging for the government."@TJRyan_77 discusses the need to #CrushtheCurve#TonightVMTV pic.twitter.com/FkflhsYjhO
— TonightVMTV (@TonightVMTV) June 10, 2020
https://t.co/RfU4rqjLoR
"The pandemic is not a failure of individuals, it's a failure of the system. Everyone is trying their best at every level but it's just not working ."@TJRyan_77 on what must be done to avoid a future of rolling lockdowns.#TonightVMTV pic.twitter.com/fEwPT3vKS6
— TonightVMTV (@TonightVMTV) November 24, 2020

https://t.co/3nl2bQKCTf
Dr Tom\xe1s Ryan explains how a #ZeroCovid approach might work.
— Claire Byrne Live (@ClaireByrneLive) January 25, 2021
'You treat every #Covid case like a murder' #cblive pic.twitter.com/BkpSEthbuo
https://t.co/HZTUDT7OTK
https://t.co/r4RebwM1pH
'There is only one strategy for dealing with the pandemic - get it down, get it out and keep it out.'@TJRyan_77 discusses the need for a 0 covid strategy#TonightVMTV pic.twitter.com/bgrbL3lmxo
— TonightVMTV (@TonightVMTV) February 10, 2021
“How Dare You”. How dare he talk about "mental health"
It is this ludicrous insistence on keeping countries locked down and people quarantined why people’s mental health is shot to pieces. Not the virus.
https://t.co/LjeJWj2SBY
More from Health
1/13
A thread based on Figure 1
A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13

Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13

Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13

The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13

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Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
